Results 71 to 80 of about 2,622 (160)
In vitro anti-trypanosomal activity of Morinda lucida leaves
AFRICAN JOURNAL OF BIOTECHNOLOGY, 2012 Bioassay-guided fractionation of the crude methanol extract of Morinda lucida Benth. (Rubiaceae) was carried out by column chromatography and anti-trypanosomal activity was tested using in vitro cultures of Trypanosoma brucei brucei S427. Three active fractions (ML 13-18, ML 19-28 and ML 33-45) were obtained with minimum inhibitory concentration (MIC ...
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The Burden of Neglected Tropical Diseases in Rwanda: A Scoping Review
Health Science Reports, Volume 8, Issue 8, August 2025.ABSTRACT Background and Aims Rwanda is among the African countries affected by neglected tropical diseases (NTDs). This scoping review aims to synthesize available information to understand the prevalence, incidence, distribution, morbidity, mortality, and risk factors of NTDs in Rwanda.
Masceline Jenipher Mutsaka‐Makuvaza +9 more
wiley +1 more source
Heliyon, 2019 Poly(amidoamine) and Poly(propylenimine) dendrimers with different generations and peripheral groups were studied as solubility enhancers and nanocarriers for 7-bromo-2-hydroxy-phenazine N5,N10-dioxide.
Nahir Dib +9 more
doaj +1 more source
Overproduction and Characterization of Recombinant Soluble Trypanosoma brucei Phospholipase A2
Engineering in Life Sciences, Volume 25, Issue 3, March 2025.ABSTRACT Trypanosoma brucei phospholipase A2 (TbPLA2) is a validated drug target but the difficulty in expressing its soluble recombinant protein has limited its exploitation for drug and vaccine development for African and American trypanosomiases. We utilized recombinant deoxyribonucleic acid (DNA) technology approaches to express soluble TbPLA2 in ...
Oluwafemi Abiodun Adepoju +9 more
wiley +1 more source
The carbonic anhydrase enzymes as new targets for the management of neglected tropical diseases
Archiv der Pharmazie, Volume 358, Issue 1, January 2025.The scientific literature dealing with the identification and development of selective inhibitors of the carbonic anhydrases expressed by the protozoans Trypanosoma cruzi (T. cruzi) and Leishmania spp. is reviewed and analyzed, with the aim to sustain the validation process of new classes of drugs useful for the management of neglected tropical ...
Gioele Renzi +3 more
wiley +1 more source
Advances in QSAR analysis of anti-trypanosomal activity
, 2017 Trypanosomiasis, also known as sleeping sickness, is a vector-borne parasitic disease transmitted by tsetse fly (Glossina genus) and caused by kinetoplastid Trypanosoma. We have investigated quantitative structure–activity relationship (QSAR) of anti-trypanosomal activities of natural compounds polyphenols [1], as well as synthetic compounds: pyridyl ...
Rastija, Vesna, Masand, Vijay H.
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Neglected Tropical Diseases and Female Infertility: Possible Pathophysiological Mechanisms
Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.Battling female infertility has posed a global challenge, where neglected tropical diseases (NTDs) are nonetheless a notable contributing factor. NTDs affect a variety of diseases, often of a chronic nature, which are often cited as some of the most lethal diseases operating against the most economically disadvantaged populations across the globe.
Moses Agbomhere Hamed +8 more
wiley +1 more source
ESI MS Studies of T. Brucei Trypanothione Reductase and its Reactions With Selected Metal Compounds
European Journal of Inorganic Chemistry, Volume 27, Issue 36, December 20, 2024.The study investigates the interactions between Trypanothione reductase from Trypanosoma brucei (TbTR) and selected metal compounds using ESI‐MS measurements. The findings describe how these compounds bind to TbTR, highlighting their potential as novel anti‐parasitic agents by targeting this crucial enzyme, which is essential for the parasite's ...
Stefano Zineddu +7 more
wiley +1 more source
European Journal of Heart Failure, Volume 26, Issue 12, Page 2502-2514, December 2024.Main pathophysiological components influencing mortality in chronic Chagas cardiomyopathy. LV, left ventricular; PVC, premature ventricular contraction; VT, ventricular tachycardia. Chagas disease is a neglected tropical disease caused by the parasite Trypanosoma cruzi.
Luis E. Echeverría +5 more
wiley +1 more source
Anti-Trypanosomal Activity of Guiera senegalensis on Trypanosoma brucei Infected Mice
Journal of Drug Delivery and Therapeutics, 2019 Aqueous decoction of Guiera senegalensis leaves was studied orally and intraperitoneally for its antitrypanosomal activity on mice infected experimentally with Trypanosoma brucei brucei. After a phytochemical screening followed by an acute toxicity study on mice, the extract of plant was administered once daily for 2 days at doses of 60, 120 and 240 mg
Belem Adrien Marie Gaston +6 more
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