Anti-trypanosomal activity and cytotoxicity of some compounds and extracts from Nigerian medicinal plants [PDF]
, 2011 This chapter explores the anti-trypanosomal activity and cytotoxicity of some compounds and extracts from Nigerian medicinal ...
Hazar A. +11 more
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Screening, identification, structure-activity, and mode of action studies with new antitrypanosomal leads of plant and fungal origin [PDF]
, 2013 Human African trypanosomiasis (HAT) is a neglected disease caused by the protozoan Trypanosoma brucei, which is transmitted during blood-feeding tsetse fly bites.
Zimmermann, Stefanie
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Orally Active and Selective Tubulin Inhibitors as Anti-Trypanosome Agents
PLOS ONE, 2016 There is an urgent need to develop a safe, effective, orally active, and inexpensive therapy for African trypanosomiasis due to the drawbacks of current drugs. Selective tubulin inhibitors have the potential to be promising drug candidates for the treatment of this disease, which is based on the tubulin protein structural difference between mammalian ...
Vishal Nanavaty +8 more
openaire +4 more sources
Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. [PDF]
PLoS Neglected Tropical Diseases, 2018 Due to toxicity and compliance issues and the emergence of resistance to current medications new drugs for the treatment of Human African Trypanosomiasis are needed. A potential approach to developing novel anti-trypanosomal drugs is by inhibition of the
Eva Doleželová +9 more
doaj +1 more source
In vitro anti-trypanosomal activity of Bitis arietans crude venom against Trypanosoma brucei brucei [PDF]
, 2019 African Animal trypanosomosis (AAT) otherwise known as Nagana is a resurgent disease in Africa. It is caused by Trypanosoma brucei brucei, Trypanosoma congolense, Trypanosoma vivax, Trypanosoma evansi among others.
Peter, G, Chechet, G.D.
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Anti-trypanosomal Phenolic Derivatives from
Natural Product Communications, 2014 Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a ...
Simone dos S. Grecco +7 more
doaj +1 more source
Synthesis and Optimisation of P3 Substituted Vinyl Sulfone-Based Inhibitors as Anti-Trypanosomal Agents [PDF]
, 2020 A series of lysine-based vinyl sulfone peptidomimetics were synthesised and evaluated for anti-trypanosomal activity against bloodstream forms of T. brucei.
Knox, Andrew +4 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Amidinobenzimidazole derivatives connected to 1-aryl-substituted 1,2,3-triazole through phenoxymethylene linkers 7a–7e, 8a–8e, and 9a–9e were designed and synthesised with the aim of evaluating their anti-bacterial and anti-trypanosomal activities and ...
Andrea Bistrović +8 more
doaj +1 more source
Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia [PDF]
A search for anti-trypanosomal natural compounds from plants collected in El Salvador, a country particularly endemic for Chagas disease, resulted in the isolation of five lignan-type compounds (1–5) from Peperomia pseudopereskiifolia.
Junko Nakajima-Shimada (3060789) +8 more
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Anti-trypanosomal cadinanes synthesized by transannular cyclization of the natural sesquiterpene lactone nobilin [PDF]
, 2015 Acid-catalyzed transannular cyclization of the germacrene-type sesquiterpene lactone nobilin 1 was investigated with the aim of obtaining new anti-trypanosomal cadinane derivatives.
Thormann, U. +5 more
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