Results 51 to 60 of about 2,622 (160)

Potential Mechanism of the Anti-trypanosomal Activity of Organoruthenium Complexes with Bioactive Thiosemicarbazones

Biological Trace Element Research, 2013
In the search for new metal-based drugs against diseases produced by trypanosomatid parasites, four organoruthenium(II) compounds [Ru2(p-cymene)2(L)2]X2, where L are bioactive 5-nitrofuryl-containing thiosemicarbazones and X = Cl or PF6, had been previously obtained.
Demoro, Bruno, Rossi, Miriam, Caruso, Francesco, Liebowitz, Daniel, Olea Azar, Claudio, Kemmerling Weis, Ulrike, Maya Arango, Juan, Guiset, Helena, Moreno, Virtudes, Pizzo, Chiara, Mahler, Graciela, Otero, Lucía, Gambino, Dinorah   +12 more
openaire   +2 more sources

In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

Química Nova, 2012
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized.
Patricia Sartorelli, Jefferson S. Santana, Rafael C. Guadagnin, João Henrique G. Lago, Érika G. Pinto, André G. Tempone, Hélio A. Stefani, Marisi G. Soares, Adalberto M. da Silva   +8 more
doaj   +1 more source

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae)

Química Nova, 2012
MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D ...
Roberta T. dos Santos, Liliane L. Hiramoto, João Henrique G. Lago, Patrícia Sartorelli, André G. Tempone, Erika G. Pinto   +5 more
doaj   +1 more source

Bactericidal, Bacteriostatic, and Fungicidal Activities of Clausena anisata Fruit and Its Compounds, Stigmasteryl 3‐Palmitate (a Phytosterol Ester) and Phellopterin (a Furanocoumarin), Against Some Clinical Pathogens

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
C. anisata fruit extract and its compounds demonstrated potent broad‐spectrum antimicrobial activity, notably against Klebsiella pneumoniae (MIC 0.625 mg/mL; MLC 2.5 mg/mL) and Candida albicans (MIC 0.0781 mg/mL; MLC 0.625 mg/mL). The findings highlight promising bactericidal and fungicidal potential of stigmasteryl 3‐palmitate and phellopterin against
Emmanuel Kofi Kumatia, Alex Asase, Prince Kyei Baffour, Borge Leth Frimpong, Ernest Agyei, Nguyen Huu Tung   +5 more
wiley   +1 more source

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense

Molecules, 2017
In our continued search for natural compounds with activity against Trypanosoma brucei, causative agent of human African trypanosomiasis (HAT, “sleeping sickness”), we have investigated extracts from the leaves and bark of the West African Holarrhena ...
Charles Okeke Nnadi, Ngozi Justina Nwodo, Marcel Kaiser, Reto Brun, Thomas J. Schmidt   +4 more
doaj   +1 more source

Graphene quantum dots induce cascadic apoptosis via interaction with proteins associated with anti-oxidation after endocytosis by Trypanosoma brucei

Frontiers in Immunology, 2022
Trypanosoma brucei, the pathogen causing African sleeping sickness (trypanosomiasis) in humans, causes debilitating diseases in many regions of the world, but mainly in African countries with tropical and subtropical climates.
Yiwei Xie, Yiwei Xie, Yiwei Xie, Hongrui Liang, Hongrui Liang, Hongrui Liang, Ning Jiang, Ning Jiang, Ning Jiang, Dingyuan Liu, Dingyuan Liu, Dingyuan Liu, Naiwen Zhang, Naiwen Zhang, Naiwen Zhang, Qilong Li, Qilong Li, Qilong Li, Kai Zhang, Kai Zhang, Kai Zhang, Xiaoyu Sang, Xiaoyu Sang, Xiaoyu Sang, Ying Feng, Ying Feng, Ying Feng, Ran Chen, Ran Chen, Ran Chen, Yiwei Zhang, Yiwei Zhang, Yiwei Zhang, Qijun Chen, Qijun Chen, Qijun Chen   +35 more
doaj   +1 more source

CHARACTERIZATION AND ANTIPARASITIC ACTIVITY OF BENZOPHENONE THIOSEMICARBAZONES ON Trypanosoma brucei brucei

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2011
The structure of four synthesized thiosemicarbazones, substituted or not, of benzophenone has been confirmed by spectrometrical analysis IR, NMR 1H and 13C. Their anti-trypanosomal activities were evaluated on Trypanosoma brucei brucei.
Georges C. Accrombessi, Jacques Poupaert, Raymond H. Fatondji, Salomé D. S. Kpoviessi, Fernand A. Gbaguidi, Bienvenu Glinma   +5 more
doaj  

Anti-trypanosomal Potential of Methanolic Extract of Calotropis gigantea Leaves against Trypanosma evansi and its Cytotoxicity

International Journal of Bio-Resource and Stress Management, 2023
In an attempt to find anti-trypanosomal extract/compound(s) from medicinal plant for the treatment of trypanosomosis, Calotropis gigantea leaves were extracted with methanol. The obtained extract was screened at concentrations (250-1000 μg ml-1) against 
P. Shaba, N. N. Pandey, O. P. Sharma, J. R. Rao, R. K. Singh   +4 more
doaj  

Crosspteryx fibrifuga leaf extract enhances host resistance to Trypanosoma congolense infection in mice by regulating host immune response and disrupting the activity of parasite superoxide dismutase enzyme

Frontiers in Microbiology, 2023
African trypanosomiasis, a neglected tropical disease, is caused by diverse species of the protozoan parasite belonging to the genus Trypanosoma. Although anti-trypanosomal medications exist, the increase in drug resistance and persistent antigenic ...
Nnamdi Ikeogu, Folayemi Olayinka-Adefemi, Chidalu Edechi, Chukwunonso Onyilagha, Ping Jia, Aaron Marshall, Julius Ode, Jude Uzonna   +7 more
doaj   +1 more source