Results 31 to 40 of about 7,391,676 (191)

Molecular identification of Trypanosoma brucei brucei and in vitro anti-trypanosomal activity of different parts of methanolic extract of Senna occidentalis

Clinical Phytoscience, 2020
Objective The present study investigated the anti-Trypanosoma brucei brucei activity of methanolic extract of Senna occidentalis roots, leaves, stem bark, and seed in vitro and bioactive components of the most active plant part.
Zainab Aliyu Alhafiz, Mohammed Sani Abdulsalami, Mohammed Auwal Ibrahim, Timothy Bulus, Ahmed Babangida Suleiman   +4 more
doaj   +1 more source

ANTI‐TRYPANOSOMAL ACTIVITY OF CERTAIN PHENYLDIAZOAMINO‐ AND PHENYLAZOAMINO‐PHENANTHRIDINIUM COMPOUNDS [PDF]

British Journal of Pharmacology and Chemotherapy, 1961
Red phenyldiazoaminophenanthridinium and purple phenylazoaminophenanthridinium compounds, most of which were obtained as isomeric pairs, were tested in mice for curative and prophylactic action against Trypanosoma congolense. Several of the individual compounds showed a high degree of activity, the red isomer of each pair usually being more active ...
K N, BROWN, J, HILL, A E, HOLLAND
openaire   +2 more sources

Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae) [PDF]

, 2013
BACKGROUND: Malaria, trypanosomiasis and leishmaniasis have an overwhelming impact in the poorest countries in the world due to their prevalence, virulence and drug resistance ability.
Swaleh, S. M., Hassanali, Ahmed, Ndiege, Isaiah O, Brun, R., Dalsgaard, Petur, Ahmed Hassanali, Ndiege, I. O., Malebo, Hamisi M, Monical Cal, Petur Dalsgaard, Maurice O Omolo, Hassanali, A., Wenzler, T., Sequin, U., Hamburger, M., Wenzler, Tanja, Tanja Wenzler, Omolo, M. O., Omolo, Maurice O, Hamisi M Malebo, Dalsgaard, P., Cal, M., Häussinger, Daniel, Daniel Häussinger, Häussinger, D., Hamburger, Matthias, Brun, Reto, Sauda M Swaleh, Malebo, H. M., Séquin, Urs, Isaiah O Ndiege, Reto Brun, Cal, Monical, Swaleh, Sauda M, Urs Séquin, Matthias Hamburger   +35 more
core   +2 more sources

Chemical characterization of Saudi propolis and its antiparasitic and anticancer properties

Scientific Reports, 2021
Propolis, is a gummy material produced by honey bees from different parts of plants and is enriched with varied biological active compounds like flavonoids, phenolics and phenolic acids with wide applicability in the food, pharmaceutical and cosmetics ...
Samyah Alanazi, Naif Alenzi, Fouza Alenazi, Hajera Tabassum, David Watson   +4 more
doaj   +1 more source

EUCALYPTUS OIL NANOEMULSION: EVALUATION OF IN VITRO ACTIVITY AGAINST TRYPANOSOMA BRUCEI [PDF]

Zagazig Journal of Pharmaceutical Sciences
Background: Natural products and their secondary metabolites are a good source of pharmacologically active constituents and have been widely developed into modern medicines.
Emmanuel Maduabuchi Uronnachi, Patience Sunday Ngbo, Somtochukwu Richard Ewuzie, Chidalu Benedicta Ikeotuonye, Anthony Amaechi Attama   +4 more
doaj   +1 more source

Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads. [PDF]

PLoS Neglected Tropical Diseases, 2011
Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), expresses two proteins with homology to human glycogen synthase kinase 3β (HsGSK-3) designated TbruGSK-3 short and TbruGSK-3 long.
Richard O Oduor, Kayode K Ojo, Gareth P Williams, Francois Bertelli, James Mills, Louis Maes, David C Pryde, Tanya Parkinson, Wesley C Van Voorhis, Tod P Holler   +9 more
doaj   +1 more source

Establishment of a structure-activity relationship of the 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness [PDF]

, 2014
The compound NVP-BEZ235 (1) is a potent inhibitor of human phospoinositide-3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) that also showed high inhibitory potency against T. brucei cultures. With an eye towards using 1 as a starting point for
Pollastri, Michael P, Smith, Terry K, Berlanga, Manuela, Luengo-Arratta, Sandra A, Rojas-Barros, Domingo I, Saldivia, Manuel, Diaz, Rosario, Gonzalez, Silvia, Seixas, João D, Manzano, Pilar, Navarro, Miguel   +10 more
core   +1 more source

Correction: Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies

PLoS Neglected Tropical Diseases, 2012
The image for Figure 1 is incorrect.
Guy Caljon, Benoît Stijlemans, Dirk Saerens, Jan Van Den Abbeele, Serge Muyldermans, Stefan Magez, Patrick De Baetselier   +6 more
openaire   +4 more sources

Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi

Molbank, 2022
In this work, we present the synthesis and the anti-trypanosomal activity of the 2-(4-(adamant-1-yl)phenyl)-N-hydroxyarylamides, 1a,b and the 2-(4-(adamant-1-yl)phenoxy)-N-hydroxyacetamide, 1c.
Angeliki Sofia Foscolos, Andrew Tsotinis, Martin C. Taylor, John M. Kelly, Ioannis P. Papanastasiou   +4 more
doaj   +1 more source

Hinokinin, an Emerging Bioactive Lignan

Molecules, 2014
Hinokinin is a lignan isolated from several plant species that has been recently investigated in order to establish its biological activities. So far, its cytotoxicity, its anti-inflammatory and antimicrobial activities have been studied.
Maria Carla Marcotullio, Azzurra Pelosi, Massimo Curini   +2 more
doaj   +1 more source