Neural Damage in Experimental Trypanosoma brucei gambiense Infection: The Suprachiasmatic Nucleus [PDF]
Frontiers in Neuroanatomy, 2018 Trypanosoma brucei (T. b.) gambiense is the parasite subspecies responsible for most reported cases of human African trypanosomiasis (HAT) or sleeping sickness.
Chiara Tesoriero +4 more
doaj +6 more sources
Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria [PDF]
Parasites & Vectors, 2019 Background Animal trypanosomosis is endemic in Nigeria, while the human disease caused by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th century.
Paschal Ugochukwu Umeakuana +3 more
doaj +7 more sources
Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense [PDF]
Nature Communications, 2022 Decreased functionality and expression of trypanosome haptoglobin-hemoglobin receptor (HpHbR) is one of the evolutionary modifications that have allowed Trypanosoma brucei gambiense to infect humans. Here, Horakova et al.
Eva Horáková +8 more
doaj +2 more sources
Whole-Genome Sequencing of
mBio, 2013 Human African trypanosomiasis is caused by two subspecies of Trypanosoma brucei. Trypanosoma brucei rhodesiense is found in East Africa and frequently causes acute disease, while Trypanosoma brucei gambiense is found in West Africa and is associated with
Ian Goodhead +10 more
doaj +7 more sources
Two-Year Follow-Up of Trypanosoma brucei gambiense Serology after Successful Treatment of Human African Trypanosomiasis: Results of Four Different Sero-Diagnostic Tests [PDF]
Diagnostics, 2022 Gambiense human African trypanosomiasis (gHAT), also known as gambiense sleeping sickness, is a parasitic infection caused by Trypanosoma brucei gambiense. During the last decades, gHAT incidence has been brought to an all-time low.
Raquel Inocencio da Luz +7 more
doaj +2 more sources
Evidence of the absence of human African trypanosomiasis in two northern districts of Uganda: Analyses of cattle, pigs and tsetse flies for the presence of Trypanosoma brucei gambiense. [PDF]
PLoS Neglected Tropical Diseases, 2020 BACKGROUND:Large-scale control of sleeping sickness has led to a decline in the number of cases of Gambian human African trypanosomiasis (g-HAT) to
Lucas J Cunningham +7 more
doaj +2 more sources
PLoS Neglected Tropical Diseases, 2010 BackgroundTrypanosoma brucei gambiense is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central Africa.
Andrew Paul Jackson +2 more
exaly +3 more sources
PLoS Neglected Tropical Diseases, 2011 BackgroundThe three sub-species of Trypanosoma brucei are important pathogens of sub-Saharan Africa. T. b. brucei is unable to infect humans due to sensitivity to trypanosome lytic factors (TLF) 1 and 2 found in human serum. T. b. rhodesiense and T.
Paul Capewell +2 more
exaly +2 more sources
Development of a camelid single-domain antibody-based antigen detection assay for the pan-specific diagnosis of active human and animal Trypanosoma brucei infections [PDF]
Journal of Clinical MicrobiologyTrypanosoma brucei infections cause African trypanosomiasis, also known as sleeping sickness in humans and nagana in animals, presenting a significant global health and economic burden, especially in sub-Saharan Africa.
Zeng Li +8 more
doaj +2 more sources
Population genetics of trypanosoma brucei rhodesiense: clonality and diversity within and between foci [PDF]
, 2013 African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
A MacLeod +70 more
core +55 more sources