Results 1 to 10 of about 338 (128)

The TgsGP Gene Is Essential for Resistance to Human Serum in Trypanosoma brucei gambiense [PDF]

PLoS Pathogens, 2013
Trypanosoma brucei gambiense causes 97% of all cases of African sleeping sickness, a fatal disease of sub-Saharan Africa. Most species of trypanosome, such as T. b.
Paul Capewell, Caroline Clucas, Rudo Kieft   +2 more
exaly   +6 more sources

Trypanosoma brucei gambiense Group 2: The Unusual Suspect

Trends in Parasitology, 2019
Trypanosoma brucei causes human African trypanosomiasis (HAT). Three subspecies were described: T. b. gambiense (Tbg) and T. b. rhodesiense (Tbr) in humans, and T. b. brucei (Tbb) in animals. Molecular markers subdivided Tbg into two groups: Tbg1 and Tbg2, of which the latter is different from Tbg1 and Tbr (absence of the SRA gene), but ...
Vincent Jamonneau, Philippe Truc, Stéphane Herder   +2 more
exaly   +6 more sources

Neural Damage in Experimental Trypanosoma brucei gambiense Infection: The Suprachiasmatic Nucleus [PDF]

Frontiers in Neuroanatomy, 2018
Trypanosoma brucei (T. b.) gambiense is the parasite subspecies responsible for most reported cases of human African trypanosomiasis (HAT) or sleeping sickness.
Chiara Tesoriero, Yuan-Zhong Xu, Dieudonné Mumba Ngoyi, Marina Bentivoglio, Marina Bentivoglio   +4 more
doaj   +4 more sources

The Genome Sequence of Trypanosoma brucei gambiense, Causative Agent of Chronic Human African Trypanosomiasis

PLoS Neglected Tropical Diseases, 2010
BackgroundTrypanosoma brucei gambiense is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central Africa.
Andrew P Jackson, Mandy Sanders, Andrew Berry   +2 more
exaly   +3 more sources

Differences between Trypanosoma brucei gambiense Groups 1 and 2 in Their Resistance to Killing by Trypanolytic Factor 1

PLoS Neglected Tropical Diseases, 2011
BackgroundThe three sub-species of Trypanosoma brucei are important pathogens of sub-Saharan Africa. T. b. brucei is unable to infect humans due to sensitivity to trypanosome lytic factors (TLF) 1 and 2 found in human serum. T. b. rhodesiense and T.
Paul Capewell, C Michael R Turner, Jayne Raper   +2 more
exaly   +2 more sources

Identification of Trypanosoma brucei gambiense in naturally infected dogs in Nigeria [PDF]

Parasites & Vectors, 2019
Background Animal trypanosomosis is endemic in Nigeria, while the human disease caused by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th century.
Paschal Ugochukwu Umeakuana, Wendy Gibson, Romanus Chukwuduruo Ezeokonkwo, Boniface Maduka Anene   +3 more
doaj   +4 more sources

The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Côte d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense

PLoS Neglected Tropical Diseases, 2017
BackgroundImportant control efforts have led to a significant reduction of the prevalence of human African trypanosomiasis (HAT) in Côte d'Ivoire, but the disease is still present in several foci.
Martial Kassi N'Djetchi, Hamidou Ilboudo, Mathurin Koffi   +2 more
exaly   +2 more sources

Molecular evidence of a Trypanosoma brucei gambiense sylvatic cycle in the human african trypanosomiasis foci of Equatorial Guinea

Frontiers in Microbiology, 2015
Gambiense trypanosomiasis is considered an anthroponotic disease. Consequently, control programs are generally aimed at stopping transmission of Trypanosoma brucei gambiense (T. b. gambiense) by detecting and treating human cases.
Amalia Fernández-Martínez, Jorge Cano, MIGUEL Navarro   +2 more
exaly   +3 more sources

VSGs Expressed during Natural T. b. gambiense Infection Exhibit Extensive Sequence Divergence and a Subspecies-Specific Bias towards Type B N-Terminal Domains

mBio, 2022
Trypanosoma brucei gambiense is the primary causative agent of human African trypanosomiasis (HAT), a vector-borne disease endemic to West and Central Africa.
Jaime So, Sarah Sudlow, Abeer Sayeed, Tanner Grudda, Stijn Deborggraeve, Dieudonné Mumba Ngoyi, Didier Kashiama Desamber, Bill Wickstead, Veerle Lejon, Monica R. Mugnier   +9 more
doaj   +1 more source

Therapeutic Strategies against Leishmania and Trypanosoma

Pathogens, 2023
Human African trypanosomiasis (also known as sleeping sickness, with Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense as etiological agents), American trypanosomiasis (also known as Chagas disease, with Trypanosoma cruzi as the etiological
André L. S. Santos, Igor A. Rodrigues, Claudia M. d’Avila-Levy, Cátia L. Sodré, Koert Ritmeijer, Marta H. Branquinha   +5 more
doaj   +1 more source