Results 41 to 50 of about 53,099 (190)

Wild chimpanzees are infected by Trypanosoma brucei

International Journal for Parasitology: Parasites and Wildlife, 2015
Although wild chimpanzees and other African great apes live in regions endemic for African sleeping sickness, very little is known about their trypanosome infections, mainly due to major difficulties in obtaining their blood samples.
Milan Jirků, Jan Votýpka, Klára J. Petrželková, Kateřina Jirků-Pomajbíková, Eva Kriegová, Roman Vodička, Felix Lankester, Siv Aina J. Leendertz, Roman M. Wittig, Christophe Boesch, David Modrý, Francisco J. Ayala, Fabian H. Leendertz, Julius Lukeš   +13 more
doaj   +1 more source

In silico analysis of the HSP90 chaperone system from the African trypanosome, Trypanosoma brucei

Frontiers in Molecular Biosciences, 2022
African trypanosomiasis is a neglected tropical disease caused by Trypanosoma brucei (T. brucei) and spread by the tsetse fly in sub-Saharan Africa. The trypanosome relies on heat shock proteins for survival in the insect vector and mammalian host.
Miebaka Jamabo, Stephen John Bentley, Paula Macucule-Tinga, Praise Tembo, Adrienne Lesley Edkins, Aileen Boshoff   +5 more
doaj   +1 more source

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

International Journal for Parasitology: Drugs and Drug Resistance, 2015
Aquaglyceroporin-2 is a known determinant of melarsoprol–pentamidine cross-resistance in Trypanosoma brucei brucei laboratory strains. Recently, chimerization at the AQP2–AQP3 tandem locus was described from melarsoprol–pentamidine cross-resistant ...
Fabrice E. Graf, Nicola Baker, Jane C. Munday, Harry P. de Koning, David Horn, Pascal Mäser   +5 more
doaj   +1 more source

Whole-Genome Sequencing of Trypanosoma brucei Reveals Introgression between Subspecies That Is Associated with Virulence

mBio, 2013
Human African trypanosomiasis is caused by two subspecies of Trypanosoma brucei. Trypanosoma brucei rhodesiense is found in East Africa and frequently causes acute disease, while Trypanosoma brucei gambiense is found in West Africa and is associated with
Ian Goodhead, Paul Capewell, J. Wendi Bailey, Tanja Beament, Michael Chance, Suzanne Kay, Sarah Forrester, Annette MacLeod, Mark Taylor, Harry Noyes, Neil Hall   +10 more
doaj   +1 more source

Screening of Trypanosoma brucei gambiense in domestic livestock and tsetse flies from an insular endemic focus (Luba, Equatorial Guinea). [PDF]

, 2010
BACKGROUND: Sleeping sickness is spread over 36 Sub-Saharan African countries. In West and Central Africa, the disease is caused by Trypanosoma brucei gambiense, which produces a chronic clinical manifestation.
Abaga, Simón, Pedro Ndongo-Asumu, Ochando, Jordi, Ndong-Mabale Nicolás, Carmen García-Estébanez, Nicolás Ndong-Mabale, Ndong-Mabale, Nicolás, Agustín Benito, Carlos Cordon-Obras, Ndongo-Asumu, Pedro, Benito Agustín, García-Estébanez, Carmen, Cano, Jorge, Cordon-Obras, Carlos, Cano Jorge, Benito, Agustín, Cordon-Obras Carlos, Simón Abaga, Abaga Simón, Ndongo-Asumu Pedro, Jorge Cano, García-Estébanez Carmen   +21 more
core   +2 more sources

Human and animal Trypanosomes in Côte d'Ivoire form a single breeding population.

PLoS ONE, 2013
BackgroundTrypanosoma brucei is the causative agent of African Sleeping Sickness in humans and contributes to the related veterinary disease, Nagana. T. brucei is segregated into three subspecies based on host specificity, geography and pathology. T.
Paul Capewell, Anneli Cooper, Craig W Duffy, Andy Tait, C Michael R Turner, Wendy Gibson, Dieter Mehlitz, Annette Macleod   +7 more
doaj   +1 more source

Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda. [PDF]

, 2006
OBJECTIVES: Our objective was to compare the efficacy and safety of three drug combinations for the treatment of late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense.
Louga, Albino, Fogg Carole, Louga Albino, Ghabri, S, Piola, P, Piola, Patrice, Balasegaram, M, Checchi Francesco, Balasegaram, Manica, Priotto Gerardo, Louga, A, Checchi, F, Priotto, Gerardo, Priotto, G, Erphas, Olema, Checchi, Francesco, Ghabri, Salah, Erphas, O, Balasegaram Manica, Ghabri Salah, Erphas Olema, Fogg, C, Fogg, Carole, Piola Patrice   +23 more
core   +1 more source

Free-ranging pigs identified as a multi-reservoir of Trypanosoma brucei and Trypanosoma congolense in the Vavoua area, a historical sleeping sickness focus of Côte d'Ivoire.

PLoS Neglected Tropical Diseases, 2021
BackgroundThe existence of an animal reservoir of Trypanosoma brucei gambiense (T. b. gambiense), the agent of human African trypanosomiasis (HAT), may compromise the interruption of transmission targeted by World Health Organization.
Barkissa Mélika Traoré, Mathurin Koffi, Martial Kassi N'Djetchi, Dramane Kaba, Jacques Kaboré, Hamidou Ilboudo, Bernadin Ahouty Ahouty, Minayégninrin Koné, Bamoro Coulibaly, Thomas Konan, Adeline Segard, Lingué Kouakou, Thierry De Meeûs, Sophie Ravel, Philippe Solano, Jean-Mathieu Bart, Vincent Jamonneau   +16 more
doaj   +1 more source

Isolation, propagation and characterization of "Trypanosoma brucei gambiense" from human African trypanosomosis patients in south Sudan [PDF]

, 2006
Sleeping sickness or Human African trypanosomosis (HAT) is a protozoal disease that is transmitted by tsetse fly vectors in Africa. Sleeping sickness due to T. b.
Maina, Naomi Wangari Njogu
core   +1 more source

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign [PDF]

, 2012
Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regimes ...
Moawad, S. R., Baell, Jonathan, Sykes, Melissa L, Kaiser Marcel, Moawad Sarah R., Ganame Danny, Sykes Melissa L., Chatelain Eric, Avery Vicky M., Vicky M Avery, Ioset Jean-Robert, Ganame, D., Baell, Jonathan Bayldon, Avery, Vicky, Moawad, Sarah R., Kaiser, Marcel, Baell Jonathan B., Avery, V. M., Danny Ganame, Baell, Jonathan B, Marcel Kaiser, Melissa L Sykes, Ioset, J. R., Ioset, Jean, Chatelain, E., Kaiser, M., Moawad, Sarah R, Avery, Vicky M, Baell, J. B., Jonathan B Baell, Sykes, M. L., Sykes, Melissa, Ganame, Danny, Ioset, Jean-Robert, Sarah R Moawad, Chatelain, Eric, Moawad, Sarah, Jean-Robert Ioset, Baell, Jonathan B., Eric Chatelain, Ioset, Jean Robert   +40 more
core   +1 more source