Results 61 to 70 of about 4,641 (209)

Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species [PDF]

, 2012
Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and ...
Browne, H., Jackson, Andrew P., Marcello, Lucio, Jackson, A.P., Jackson, A. P., Quail, M. A., Ginger, M. L., Marcello, L., Quail, M.A., Berriman, Matthew, Jackson, Andrew P, Berry, Andrew, Field, M. C., Aslett, Martin, Sanders, Mandy J., McQuillan, J., Barry, J. David, Field, Mark C., Allinson, Harriet C., Browne, Hilary, Hauser, H., Aslett, M., Barry, J.D., Burton, Peter, Allison, Harriet C., Ginger, Michael L., Gilderthorp, Ruth, Berry, A., van Tonder, Andries, Allison, H.C., McQuillan, Jacqueline, Burton, P., Ginger, M.L., Corton, Nicola, Gilderthorp, R., Hertz-Fowler, Christiane, Field, M.C., Field, MarkC., Corton, N., Quail, Michael A., Gamble, John, Brown, R., Otto, Thomas D., Otto, T. D., Barry, J. D., Gamble, J., Hauser, Heidi, Hertz-Fowler, C., Brown, Robert, van Tonder, A., Berriman, M., Ginger, Michael, Vavrova-Anderson, Jana, Vavrova-Anderson, J., Sanders, M.J., Allison, H. C., Hertz-Fowler, Christine, Otto, T.D., Sanders, M. J.   +58 more
core   +1 more source

Case of Nigeria-Acquired Human African Trypanosomiasis in United Kingdom, 2016

Emerging Infectious Diseases, 2017
Human African trypanosomiasis has not been reported in Nigeria since 2012. Nevertheless, limitations of current surveillance programs mean that undetected infections may persist.
Akish Luintel, Patricia Lowe, Anneli Cooper, Annette MacLeod, Philippe Büscher, Tim Brooks, Mike Brown   +6 more
doaj   +1 more source

Cytotoxicity and Antimicrobial Activity of GaMF1 Analogs

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
GaMF1 is a reported, highly potent inhibitor of mycobacterial ATP synthase. Structural modification of this scaffold significantly changes biological activity. We present GaMF1 analogues with strong antiparasitic effects, potential antiproliferative properties, and discuss the selectivity limitations of the parent compound and its analogues.
Jan Chasák, Petr Vyvlečka, Ivan Nemec, An Matheeussen, Natascha Van Pelt, Paul Cos, Guy Caljon, Vladimír Kryštof, Lucie Brulíková   +8 more
wiley   +1 more source

Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty. [PDF]

, 2015
Two key biological features distinguish Trypanosoma evansi from the T. brucei group: independence from the tsetse fly as obligatory vector, and independence from the need for functional mitochondrial DNA (kinetoplast or kDNA).
Hideo Imamura (62469), Dhileep Sivam, Myler, Peter, Ivens Alasdair, McDermott, Suzanne M., Sivam Dhileep, Ramasamy, Gowthaman, Lukeš Julius, Kořený Luděk, Schnaufer, Achim, Michael Lewis (339161), Chris Merritt (682366), Severine Monnerat (3278655), De-Hua Lai, Brown, Rob, Claire Gendrin, Balmer Oliver, Merritt, Chris, Andrew Jackson, Monnerat Severine, Michael Lewis, Lun, Zhao Rong, Hideo Imamura, Wonjong Moon, Stuart, Ken, Isabelle Phan, Marc Desquesnes, Jackson, Andrew, Myler Peter, Balmer, Olivier, Alasdair Ivens, Gowthaman Ramasamy (19191), Schnaufer, Achim; id_orcid, McDermott Suzanne M., Carnes Jason, Ivens, Alasdair, Peter Myler (592207), Phan, Isabelle, Lukeš, Julius, Lun, Zhao-Rong, Lai, De Hua, Jason Carnes, Imamura Hideo, Lai De-Hua, Balmer, Oliver, Alasdair Ivens (33327), Gendrin, Claire, Lai, De-Hua, Gendrin Claire, Desquesnes, Marc, Julius Lukeš, Anupama, Atashi, Cestari, Igor, Zhao-Rong Lun, Chris Merritt, Cestari Igor, Suzanne M. McDermott (436260), Ken Stuart, Isabelle Phan (5674), Brown Rob, Peter Myler, Jackson Andrew, Suzanne M McDermott, Igor Cestari (251742), Hertz-Fowler Christiane, Rob Brown (682364), Monnerat, Severine, Julius Lukeš (122896), Lewis, Michael, Imamura, Hideo, McDermott, Suzanne M, Annette MacLeod, Stuart Ken, MacLeod Annette, Severine Monnerat, MacLeod, Annette, Anupama Atashi, Luděk Kořený (240382), Gowthaman Ramasamy, Achim Schnaufer (243262), Desquesnes Marc, Zhao-Rong Lun (104756), Ramasamy Gowthaman, Achim Schnaufer, Merritt Chris, Sivam, Dhileep, Andrew Jackson (376958), Luděk Kořený, Dhileep Sivam (682368), Hertz-Fowler, Christiane, Moon, Wonjong, Wonjong Moon (682367), Oliver Balmer, Moon Wonjong, Lewis Michael, Jason Carnes (47297), Atashi Anupama (682363), Lun Zhao-Rong, Phan Isabelle, Ken Stuart (682369), Igor Cestari, Oliver Balmer (151993), Claire Gendrin (173845), Kořený, Luděk, Atashi Anupama, Carnes, Jason, Annette MacLeod (12779), Christiane Hertz-Fowler, Marc Desquesnes (457900), Christiane Hertz-Fowler (243178), Rob Brown, Schnaufer Achim, De-Hua Lai (682365)   +112 more
core   +1 more source

Ruthenium‐Catalyzed CH Alkenylation of Trypanocidal Naphthoquinones: A Mechanistic Benchmarking Study

ChemistryOpen, Volume 15, Issue 2, February 2026.
Computational roadmap to click‐ready quinones. Quantum chemical analysis reveals how substituents modulate the reactivity of trypanocidal naphthoquinones in Ru‐catalyzed CH alkenylation, guiding the design of sulfonyl‐fluoride scaffolds for next‐generation antiparasitic agents.
Esther R. S. Paz, Cauê P. Souza, Joyce C. De Oliveira, Renata G. Almeida, Chonny Herrera‐Acevedo, Sulaiman Lakoh, Guilherme A. M. Jardim, Eufrânio N. da Silva Júnior, Felipe Fantuzzi   +8 more
wiley   +1 more source

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs [PDF]

, 2013
Objectives: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Lee, Rebecca S, Burchmore, Richard J S, Natto, Manal J, Eze, Anthonius, Graf, Fabrice, Burchmore, Richard JS, Lee, Rebecca, de Koning, Harry, Glover, Lucy, Mäser, Pascal, Teka, Ibrahim, Barrett, Michael P., Munday, Jane C., Teka, Ibrahim A., De Koning, Harry P., Eze, Anthonius A, Graf, Fabrice E., De Koning, Harry P, Ludin, Philipp, McDonald, Jennifer, MacLeod, Annette, Turner, C Michael R., Munday, Jane C, Natto, Manal J., Lee, Rebecca S., Tait, Andy, Horn, David, Baker, Nicola, Munday, Jane, Turner, C Michael R, Aguinaga Andres, David, Barrett, Michael P, Andrés, David Aguinaga, Burchmore, Richard, Clucas, Caroline, Graf, Fabrice E, Horn, David; id_orcid, Burchmore, Richard J. S., Teka, Ibrahim A, Eze, Anthonius A., Natto, Manal, Turner, C. Michael R., Barrett, Michael   +42 more
core   +1 more source

Identification of different trypanosome species in the mid-guts of tsetse flies of the Malanga (Kimpese) sleeping sickness focus of the Democratic Republic of Congo

Parasites & Vectors, 2012
Background The Malanga sleeping sickness focus of the Democratic Republic of Congo has shown an epidemic evolution of disease during the last century. However, following case detection and treatment, the prevalence of the disease decreased considerably ...
Simo Gustave, Silatsa Barberine, Flobert Njiokou, Lutumba Pascal, Mansinsa Philemon, Madinga Joule, Manzambi Emile, De Deken Reginald, Asonganyi Tazoacha   +8 more
doaj   +1 more source

Human African trypanosomiasis in two historical foci of the estuaire province, gabon: A case report

SAGE Open Medical Case Reports, 2020
Human African Trypanosomiasis (HAT) is an infectious disease due to a protozoa parasite of the Trypanosoma genus. In West and Central Africa, this disease is caused by the subspecies Trypanosoma brucei gambiense .
Berthe Amélie Iroungou, Larson Boundenga, Laurette Guignali Mangouka, Berthold Bivigou-Mboumba, Jean Raymond Nzenze, Gael Darren Maganga   +5 more
doaj   +1 more source

Vector competence of sterile male Glossina fuscipes fuscipes for Trypanosoma brucei brucei: implications for the implementation of the sterile insect technique in a sleeping sickness focus in Chad

Parasites & Vectors, 2023
Background Human African trypanosomiasis (HAT) is a neglected tropical disease caused by Trypanosoma brucei gambiense transmitted by tsetse flies in sub-Saharan West Africa. In southern Chad the most active and persistent focus is the Mandoul focus, with
Mahamat Hissene Mahamat, Adeline Ségard, Jean-Baptiste Rayaisse, Rafael Argiles-Herrero, Andrew Gordon Parker, Philippe Solano, Adly Mohamed Mohamed Abd-Alla, Jérémy Bouyer, Sophie Ravel   +8 more
doaj   +1 more source

Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence

Interdisciplinary Perspectives on Infectious Diseases, Volume 2026, Issue 1, 2026.
Trypanosomatids, including the genera Trypanosoma and Leishmania, are protozoan parasites of significant medical and veterinary relevance. These organisms cause African trypanosomiasis, Chagas disease, and leishmaniasis, which are classified as neglected tropical diseases (NTDs).
Cynthia Mmalebna Amisigo, Aboagye Kwarteng Dofuor, Jennifer Afua Afrifa Yamoah, Albert Fynn Aiduenu, Blessing Kwabena Gayi, Angelina Akomea, Zenabu Lansah Alidu, Gideon Danso, Selina Mawunyo Ayivi-Tosuh, Naa Kwarley-Aba Quartey, Joseph Harold Nyarko Osei, Seyram Kofi Loh, William Ekloh, Suraiya Saleem   +13 more
wiley   +1 more source