Results 71 to 80 of about 53,099 (190)

The natural progression of gambiense sleeping sickness: what is the evidence? [PDF]

, 2008
Gambiense human African trypanosomiasis (HAT, sleeping sickness) is widely assumed to be 100% pathogenic and fatal. However, reports to the contrary exist, and human trypano-tolerance has been postulated.
Filipe, João AN, Francesco Checchi, Barrett, M.P., Daniel Chandramohan, Checchi Francesco, Barrett, Michael P, Checchi, Francesco, Filipe, J.A.N., Chandramohan, Daniel, João A N Filipe, Barrett Michael P., Michael P Barrett, Filipe João A. N., Checchi, F., Chandramohan, D., Chandramohan Daniel   +15 more
core   +2 more sources

Geospatial Analysis of Tsetse Infestation and Animal African Trypanosomiasis in Busia County, Kenya

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
African trypanosomiasis (AT) is a vector‐borne disease caused by protozoan parasites of the genus Trypanosoma, primarily transmitted through the bite of infected tsetse flies in the genus Glossina. The disease is a major constraint to livestock production, causing reduced productivity, anemia, and mortality in affected animals.
S. S. Burudi, P. O. Mudavadi, J. K. Cheruiyot, E. O. Mungube, Satabdi Datta Choudhury   +4 more
wiley   +1 more source

Comparative analysis of cerebrospinal fluid from the meningo-encephalitic stage of T. b. gambiense and rhodesiense sleeping sickness patients using TMT quantitative proteomics

Data in Brief, 2015
The quantitative proteomics data here reported are part of a research article entitled “Increased acute immune response during the meningo-encephalitic stage of Trypanosoma brucei rhodesiense sleeping sickness compared to Trypanosoma brucei gambiense ...
Natalia Tiberti, Jean-Charles Sanchez
doaj   +1 more source

Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model. [PDF]

PLoS Neglected Tropical Diseases, 2016
Trypanosoma brucei gambiense is the main causative agent of Human African Trypanosomiasis (HAT), also known as sleeping sickness. Because of limited alternatives and treatment toxicities, new therapeutic options are urgently needed for patients with HAT.
Frédéric-Antoine Dauchy, Mélanie Bonhivers, Nicolas Landrein, Denis Dacheux, Pierrette Courtois, Florian Lauruol, Sylvie Daulouède, Philippe Vincendeau, Derrick R Robinson   +8 more
doaj   +1 more source

Control of Human African Trypanosomiasis in the Nola‐Bilolo Focus, Central African Republic, 2020–2024: Outcome of Capacity Building, Improved Diagnosis and Treatment

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
This study is aimed at evaluating the inclusion of miniature anion‐exchange centrifugation technique (mAECT) in the diagnosis and fexinidazole as treatment of gHAT in Central African Republic (CAR) after capacity building. A cross‐sectional pilot study was conducted during a mass diagnostic campaign from 16 September to 22 October 2022 in Nola‐Bilolo ...
Pierre-Marie Douzima, Mireille Cornelia Ingrid Denissio Morissi Nalingbo, Yvon Andjingbopou, Veerle Lejon, Romaric Nzoumbou-Boko, José F. Silveira   +5 more
wiley   +1 more source

Identification of Peptide Mimotopes of Trypanosoma brucei gambiense Variant Surface Glycoproteins

PLoS Neglected Tropical Diseases, 2011
The current antibody detection tests for the diagnosis of gambiense human African trypanosomiasis (HAT) are based on native variant surface glycoproteins (VSGs) of Trypanosoma brucei (T.b.) gambiense. These native VSGs are difficult to produce, and contain non-specific epitopes that may cause cross-reactions. We aimed to identify mimotopic peptides for
Van Nieuwenhove, Liesbeth Carolien, Roge, Stijn, Balharbi, Fatima, Dieltjens, Tessa, Laurent, Thierry, Guisez, Yves, Buscher, Philippe, Lejon, Veerle   +7 more
openaire   +5 more sources

Regulation of Trypanosoma brucei Total and Polysomal mRNA during Development within Its Mammalian Host [PDF]

, 2013
The gene expression of Trypanosoma brucei has been examined extensively in the blood of mammalian hosts and in forms found in the midgut of its arthropod vector, the tsetse fly.
Ivens, A, Pegine Walrad (267013), Capewell, P, Ivens, Alasdair, Terry K Smith, Keith R Matthews, Macgregor, Paula, Matthews, Keith R; id_orcid, Bringaud, F, Bringaud, Frederic, Smith, Terry K., Paul Capewell (137761), Katelyn Fenn (22199), Paula Macgregor, Smith, T, Fenn, K, Paul Capewell, Stephanie Monk, MacGregor, P, Alasdair Ivens (33327), Katelyn Fenn, Keith R. Matthews (199001), Matthews, K, Matthews, Keith R., Frederic Bringaud, Walrad, Pegine, Monk, S, Terry K. Smith (112550), Walrad, P, Stephanie Monk (427018), Matthews, Keith R, Keith R. Matthews, Frederic Bringaud (5655364), Smith, Terry K, Monk, Stephanie, Pegine Walrad, Fenn, Katelyn, Capewell, Paul, Alasdair Ivens, Terry K. Smith, Paula MacGregor (198985)   +40 more
core   +1 more source

Search for the wild animal reservoir of Trypanosoma sp in mammals of N’Djili-Brasseries (Kinshasa, Democratic Republic of Congo)

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2018
During 6 months, 201 specimens of wild mammals representing 7 species divided into 6 genera, 4 families and 3 orders, of which 2 Genetta angolensis, 3 Nandinia binotata, 10 Galagoides demidoff, 35 Protoxerus strangeri, 73 Funisciurus congicus, 15 Rattus ...
M.W. Kabamba Mwamba, G. Tshilenge, J. Malekani   +2 more
doaj  

P-type transport ATPases in Leishmania and Trypanosoma

Parasite, 2019
P-type ATPases are critical to the maintenance and regulation of cellular ion homeostasis and membrane lipid asymmetry due to their ability to move ions and phospholipids against a concentration gradient by utilizing the energy of ATP hydrolysis.
Meade John C.
doaj   +1 more source

Phase II evaluation of sensitivity and specificity of PCR and NASBA followed by oligochromatography for diagnosis of human African trypanosomiasis in clinical samples from D.R. Congo and Uganda. [PDF]

PLoS Neglected Tropical Diseases, 2010
BACKGROUND: The polymerase chain reaction (PCR) and nucleic acid sequence-based amplification (NASBA) have been recently modified by coupling to oligochromatography (OC) for easy and fast visualisation of products.
Enock Matovu, Claire M Mugasa, Rosine Ali Ekangu, Stijn Deborggraeve, George W Lubega, Thierry Laurent, Gerard J Schoone, Henk D Schallig, Philippe Büscher   +8 more
doaj   +1 more source