Results 91 to 100 of about 7,822 (201)

Overproduction and Characterization of Recombinant Soluble Trypanosoma brucei Phospholipase A2

Engineering in Life Sciences, Volume 25, Issue 3, March 2025.
ABSTRACT Trypanosoma brucei phospholipase A2 (TbPLA2) is a validated drug target but the difficulty in expressing its soluble recombinant protein has limited its exploitation for drug and vaccine development for African and American trypanosomiases. We utilized recombinant deoxyribonucleic acid (DNA) technology approaches to express soluble TbPLA2 in ...
Oluwafemi Abiodun Adepoju, Daniel Quinnell, Harshverdhan Sirohi, Emmanuel Amlabu, Abdullahi Balarabe Sallau, Abdulrazak Ibrahim, Sunday Ene‐Ojo Atawodi, Mohammed Nasiru Shuaibu, Geoffrey Chang, Emmanuel Oluwadare Balogun   +9 more
wiley   +1 more source

The system of genetic exchange in Trypanosoma brucei and other trypanosomatids [PDF]

, 2007
In this chapter, we discuss our current understanding of the systems of genetic exchange in trypanosomatids and the im-pact the recent genome projects have had on this area of research.
MacLeod, A., Tait, A., Turner, C.M.R.
core  

Novel African trypanocidal agents: membrane rigidifying peptides [PDF]

, 2012
The bloodstream developmental forms of pathogenic African trypanosomes are uniquely susceptible to killing by small hydrophobic peptides. Trypanocidal activity is conferred by peptide hydrophobicity and charge distribution and results from increased ...
Andreas Hartel, Annette MacLeod, Chris Scelsi, John M. Harrington, Markus Engstler, Nicola G. Jones, Paul Capewell, Stephen Hajduk, Sylvie Bisser   +8 more
core   +3 more sources

Retrospective clinical performance evaluation of the Abbott Bioline HAT 2.0, a rapid diagnostic test for human African trypanosomiasis based on recombinant antigens

Tropical Medicine &International Health, Volume 30, Issue 2, Page 135-142, February 2025.
Abstract Background Rapid diagnostic tests for the serological detection of gambiense human African trypanosomiasis (gHAT) have been developed to overcome the limitations of the traditional screening method, CATT/T. b. gambiense. The Abbott Bioline human African trypanosomiasis (HAT) 2.0 rapid diagnostic test has recently been developed by Abbott using
Sara Tablado Alonso, Sylvain Biéler, Raquel Inocêncio da Luz, Paul Verlé, Philippe Büscher, Epco Hasker   +5 more
wiley   +1 more source

Isolation and analysis of the genetic diversity of repertoires of VSG expression site containing telomeres from Trypanosoma brucei gambiense, T. b. brucei and T. equiperdum

BMC Genomics, 2008
Background African trypanosomes (including Trypanosoma brucei) are unicellular parasites which multiply in the mammalian bloodstream. T. brucei has about twenty telomeric bloodstream form Variant Surface Glycoprotein (VSG) expression sites (BESs), of ...
Becker Marion, Kurioka Ayako, Taylor Jesse E, Young Rosanna, Louis Edward J, Rudenko Gloria   +5 more
doaj   +1 more source

Through the dark continent: African trypanosome development in the tsetse fly [PDF]

, 2013
African trypanosomes are unicellular flagellated parasites causing trypanosomiases in Africa, a group of severe diseases also known as sleeping sickness in human and nagana in cattle.
Rotureau, Brice, Van Den Abbeele, Jan
core   +4 more sources

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

Recherche du réservoir animal sauvage de Trypanosoma sp chez les mammifères de N'Djili-Brasseries à  Kinshasa en République Démocratique du Congo (RDC)

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2017
Durant 6 mois, 201 spécimens de mammifères sauvages représentant 7 espèces réparties en 6 genres, 4 familles et 3 ordres, dont 2 Genetta angolensis, 3 Nandinia binotata, 10 Galagoides demidoff, 35 Protoxerus strangeri, 73 Funisciurus congicus, 15 Rattus
Matthieu Willy KABAMBA MWAMBA, Curé Georges TSHILENGE MBUYI, J. MALEKANI   +2 more
doaj  

African Trypanosomiasis Gambiense, Italy

Emerging Infectious Diseases, 2005
African trypanosomiasis caused by Trypanosoma brucei gambiense has not been reported in Italy. We report 2 cases diagnosed in the summer of 2004. Theses cases suggest an increased risk for expatriates working in trypanosomiasis-endemic countries.
Zeno Bisoffi, Anna Beltrame, Geraldo Monteiro, Alessandra Arzese, Stefania Marocco, Giada Rorato, Mariella Anselmi, Pierluigi Viale   +7 more
doaj   +1 more source

Exploration of Novel “Ferroxazide/Ferrazone” Derivatives as Antitrypanosomatid Agents: Design, Synthesis, and Biological Efficacy

Applied Organometallic Chemistry, Volume 39, Issue 1, January 2025.
A series of novel ferrocene derivatives, mimics of the clinical antibiotics, nifuroxazide and nitrofurazone, termed ferroxazides and ferrazones, respectively, were synthesized and evaluated for antitrypanosomatid activities. The ferroxazide 15 bearing dimethylamino moiety was identified in vitro as hit against Trypanosoma congolense strain but ...
Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source