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Human African trypanosomiasis [PDF]
BMJ, 2009 Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies.
Abel +143 more
core +7 more sources
Trypanosoma brucei brucei invasion and T-cell infiltration of the brain parenchyma in experimental sleeping sickness: timing and correlation with functional changes [PDF]
, 2016 Background: The timing of Trypanosoma brucei entry into the brain parenchyma to initiate the second, meningoencephalitic stage of human African trypanosomiasis or sleeping sickness is currently debated and even parasite invasion of the neuropil has ...
Bentivoglio, Marina +8 more
core +69 more sources
Control of Human African Trypanosomiasis in the Nola-Bilolo Focus, Central African Republic, 2020–2024: Outcome of Capacity Building, Improved Diagnosis and Treatment [PDF]
Journal of Parasitology ResearchThis study is aimed at evaluating the inclusion of miniature anion-exchange centrifugation technique (mAECT) in the diagnosis and fexinidazole as treatment of gHAT in Central African Republic (CAR) after capacity building.
Pierre-Marie Douzima +4 more
doaj +2 more sources
Current Treatments to Control African Trypanosomiasis and One Health Perspective
Microorganisms, 2022 Human African Trypanosomiasis (HAT, sleeping sickness) and Animal African Trypanosomiasis (AAT) are neglected tropical diseases generally caused by the same etiological agent, Trypanosoma brucei.
Alberto Venturelli +9 more
doaj +3 more sources
Lancet, The, 2017 Human African trypanosomiasis (sleeping sickness) is a parasitic infection that almost invariably progresses to death unless treated. Human African trypanosomiasis caused devastating epidemics during the 20th century. Thanks to sustained and coordinated efforts over the past 15 years, the number of reported cases has fallen to an historically low level.
Philippe Buscher +2 more
exaly +4 more sources
African Trypanosomiasis Gambiense, Italy
Emerging Infectious Diseases, 2005 African trypanosomiasis caused by Trypanosoma brucei gambiense has not been reported in Italy. We report 2 cases diagnosed in the summer of 2004. Theses cases suggest an increased risk for expatriates working in trypanosomiasis-endemic countries.
Zeno Bisoffi +7 more
doaj +6 more sources
Reemergence of Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense, Ethiopia [PDF]
Emerging Infectious DiseasesWe report 4 cases of human African trypanosomiasis that occurred in Ethiopia in 2022, thirty years after the last previously reported case in the country. Two of 4 patients died before medicine became available.
Adugna Abera +26 more
doaj +2 more sources
Parasites & Vectors, 2015 Background Tsetse-transmitted African trypanosomes cause both nagana (African animal Trypanosomiasis-AAT) and sleeping sickness (human African Trypanosomiasis - HAT) across Sub-Saharan Africa.
Dennis Muhanguzi +5 more
doaj +2 more sources
Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. [PDF]
PLoS Neglected Tropical Diseases, 2013 Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this ...
Jan Medlock +4 more
doaj +1 more source
BMC Pediatrics, 2022 Background In South Sudan, sleeping sickness is a frequent condition caused by human African trypanosomiasis. There are two stages that are well-known.
Etedal Ahmed A. Ibrahim +4 more
doaj +1 more source