Results 1 to 10 of about 24,248 (200)

Kynurenine Pathway Activation in Human African Trypanosomiasis [PDF]

Journal of Infectious Diseases, 2016
The kynurenine pathway of tryptophan oxidation is associated with central nervous system (CNS) inflammatory pathways. Inhibition of this pathway ameliorates CNS inflammation in rodent models of the late (meningoencephalitic) stage of human African trypanosomiasis (HAT).
Sternberg, Jeremy M., Forrest, Caroline M., Dalton, R. Neil, Turner, Charles, Rodgers, Jean, Stone, Trevor W., Kennedy, Peter G.E.   +6 more
openaire   +5 more sources

Towards the Atlas of human African trypanosomiasis

International Journal of Health Geographics, 2009
Background Updated, accurate and comprehensive information on the distribution of human African trypanosomiasis (HAT), also known as sleeping sickness, is critically important to plan and monitor control activities.
Mattioli Raffaele C, Ruiz José A, Diarra Abdoulaye, Fèvre Eric M, Franco José R, Paone Massimo, Cecchi Giuliano, Simarro Pere P   +7 more
doaj   +1 more source

Accelerating towards human African trypanosomiasis elimination: Issues and opportunities

Journal of Vector Borne Diseases, 2020
Human African trypanosomiasis (HAT) has been an alarming global public health issue. The disease affects mainly poor and marginalized people in low-resource settings and is caused by two subspecies of haemoflagellate parasite, Trypanosoma brucei and ...
Kingsley Uchenna Ozioko, Chris Ikem Okoye, Rose Nduka Obiezue, Idika Kalu Idika, Raymond Agbu Awudu, Bede Izuchukwu Ezewudo, Celestine Osita Ezea   +6 more
doaj   +1 more source

Molecular identification of different trypanosome species and subspecies in tsetse flies of northern Nigeria [PDF]

, 2016
Background: Animal African Trypanosomiasis (AAT) is caused by several species of trypanosomes including Trypanosoma congolense, T. vivax, T. godfreyi, T. simiae and T. brucei. Two of the subspecies of T. brucei also cause Human African Trypanosomiasis.
Ciosi, Marc, Dede, Peter, Hamilton, Alana, Igbinosa, Igho Benjamin, Isaac, Clement, Masiga, Dan, Nmorsi, Oyebiguwa Patrick Goddey, Scullion, Kathleen Maria, Turner, C. Michael R.   +8 more
core   +1 more source

African trypanosomes

Parasites & Vectors, 2019
African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa.
Mathieu Cayla, Federico Rojas, Eleanor Silvester, Frank Venter, Keith R. Matthews   +4 more
doaj   +1 more source

Diversity of human African trypanosomiasis epidemiological settings requires fine-tuning control strategies to facilitate disease elimination

Research and Reports in Tropical Medicine, 2013
PP Simarro,1 JR Franco,1 A Diarra,2 JA Ruiz Postigo,3 J Jannin11World Health Organization, Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, Geneva, Switzerland; 2World Health Organization, Regional Office for Africa,
Simarro PP, Franco JR, Diarra A, Ruiz Postigo JA, Jannin J   +4 more
doaj  

Pharmacological Approaches to Antitrypanosomal Chemotherapy

Memorias do Instituto Oswaldo Cruz, 1999
There is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and ...
Simon L Croft
doaj   +1 more source

Human African trypanosomiasis control: Achievements and challenges.

PLoS Neglected Tropical Diseases, 2017
Sleeping sickness, also known as human African trypanosomiasis (HAT), is a neglected disease that impacts 70 million people living in 1.55 million km2 in sub-Saharan Africa.
Serap Aksoy, Phillipe Buscher, Mike Lehane, Philippe Solano, Jan Van Den Abbeele   +4 more
doaj   +1 more source

Through the dark continent: African trypanosome development in the tsetse fly [PDF]

, 2013
African trypanosomes are unicellular flagellated parasites causing trypanosomiases in Africa, a group of severe diseases also known as sleeping sickness in human and nagana in cattle.
Rotureau, Brice, Van Den Abbeele, Jan
core   +4 more sources

A systematic review and meta-analysis of trypanosome prevalence in tsetse flies [PDF]

, 2017
Background: The optimisation of trypanosomosis control programs warrants a good knowledge of the main vector of animal and human trypanosomes in sub-Saharan Africa, the tsetse fly.
Abdi, Reta D, Agga, Getahun E, Aregawi, Weldegebrial G, Bekana, Merga, Delespaux, Vincent, Duchateau, Luc, Van Leeuwen, Thomas   +6 more
core   +2 more sources