Results 1 to 10 of about 2,882,714 (182)

Salivarian Trypanosomes Have Adopted Intricate Host-Pathogen Interaction Mechanisms That Ensure Survival in Plain Sight of the Adaptive Immune System

Pathogens, 2021
Salivarian trypanosomes are extracellular parasites affecting humans, livestock and game animals. Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense are human infective sub-species of T.
Stefan Magez, Joar Esteban Pinto Torres, Seoyeon Oh, Magdalena Radwanska   +3 more
doaj   +1 more source

Prevalence of African animal trypanosomiasis among livestock and domestic animals in Uganda: a systematic review and meta-regression analysis from 1980 to 2022

Scientific Reports, 2023
African animal trypanosomiasis (AAT) is one of the major constraints to animal health and production in sub-Saharan Africa. To inform AAT control in Uganda and help advance along the progressive control pathway (PCP), we characterized AAT prevalence ...
Karla Rascón-García, B. Martínez-López, G. Cecchi, Caterina M. Scoglio, E. Matovu, D. Muhanguzi   +5 more
semanticscholar   +1 more source

Challenges facing the elimination of sleeping sickness in west and central Africa: sustainable control of animal trypanosomiasis as an indispensable approach to achieve the goal

Parasites & Vectors, 2015
African trypanosomiases are infectious diseases caused by trypanosomes. African animal trypanosomiasis (AAT) remains an important threat for livestock production in some affected areas whereas human African trypanosomiasis (HAT) is targeted for ...
Gustave Simo, Jean Baptiste Rayaisse
doaj   +1 more source

African animal trypanosomiasis as a constraint to livestock health and production in Karamoja region: a detailed qualitative and quantitative assessment

BMC Veterinary Research, 2017
Background Nagana (African Animal Trypanosomiasis-AAT) and tick-borne diseases (TBDs) constrain livestock production in most parts of sub-Saharan Africa.
Dennis Muhanguzi, Albert Mugenyi, Godfrey Bigirwa, Maureen Kamusiime, Ann Kitibwa, Grace Gloria Akurut, Sylvester Ochwo, Wilson Amanyire, Samuel George Okech, Jan Hattendorf, Robert Tweyongyere   +10 more
doaj   +1 more source

Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model.

Journal of Medicinal Chemistry, 2019
Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa because of its huge impact on livestock health. Existing therapies including those based on minor groove binders (MGBs), such as the diamidines, which have ...
Federica Giordani, A. Khalaf, K. Gillingwater, Jane C. Munday, H. D. de Koning, C. Suckling, M. Barrett, Fraser J. Scott   +7 more
semanticscholar   +1 more source

African Animal Trypanosomiasis: A Systematic Review on Prevalence, Risk Factors and Drug Resistance in Sub-Saharan Africa

Journal of medical entomology, 2022
African animal trypanosomiasis (AAT) a parasitic disease of livestock in sub-Saharan Africa causing tremendous loses. Sub-Saharan continental estimation of mean prevalence in both large and small domestic animals, risk factors, tsetse and non-tsetse ...
Ivy Okello, E. Mafie, Gillian Eastwood, J. Nzalawahe, L. Mboera   +4 more
semanticscholar   +1 more source

A mathematical model for evaluating the role of trypanocide treatment of cattle in the epidemiology and control of Trypanosoma brucei rhodesiense and T. b. gambiense sleeping sickness in Uganda

Parasite Epidemiology and Control, 2019
Background: Human and animal African trypanosomiases impose a large economic and health burden in their endemic regions. Large strides have been made in the control of human African trypanosomiasis (HAT), yet these efforts have largely focused on the non-
Julianne Meisner, Ruanne V. Barnabas, Peter M. Rabinowitz   +2 more
doaj   +1 more source

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

Journal of Medicinal Chemistry, 2022
African animal trypanosomiasis or nagana, caused principally by infection of the protozoan parasites Trypanosoma congolense and Trypanosoma vivax, is a major problem in cattle and other livestocks in sub-Saharan Africa.
Alasdair R C Smith, Richard J. Wall, Stephen Patterson, Timothy J. Rowan, Eva Rico Vidal, L. Stojanovski, Margaret Huggett, Shahienaz E. Hampton, M. Thomas, Victoriano Corpas Lopez, K. Gillingwater, Jeff Duke, G. Napier, R. Peter, H. Vitouley, J. Harrison, R. Milne, Laura Jeacock, N. Baker, S. Davis, F. Simeons, Jennifer Riley, D. Horn, R. Brun, Fabio Zuccotto, M. Witty, S. Wyllie, K. Read, I. Gilbert   +28 more
semanticscholar   +1 more source

Cost analysis of options for management of African Animal Trypanosomiasis using interventions targeted at cattle in Tororo District; south-eastern Uganda

Parasites & Vectors, 2015
Background Tsetse-transmitted African trypanosomes cause both nagana (African animal Trypanosomiasis-AAT) and sleeping sickness (human African Trypanosomiasis - HAT) across Sub-Saharan Africa.
Dennis Muhanguzi, Walter O. Okello, John D. Kabasa, Charles Waiswa, Susan C. Welburn, Alexandra P.M. Shaw   +5 more
doaj   +1 more source

The transmission of African Animal Trypanosomiasis (nagana) in two districts in the forest zone of Ghana

bioRxiv, 2021
Animal African Trypanosomiasis also known as ‘nagana’ is a debilitating vector-borne disease caused by trypanosome parasites and transmitted to human and animals by tsetse fly of the Glossina genus within sub-Saharan Africa.
Austine Tweneboah, Jana Rosenau, A. K. Agyapong, T. Addison, Ibrahim Mahamat Alhadj Moussa, J. Weber, S. Kelm, K. Badu   +7 more
semanticscholar   +1 more source