Results 41 to 50 of about 2,882,714 (182)

Chemotherapy of second stage human African trypanosomiasis : comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys [PDF]

, 2015
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of ...
Wang, Michael Z., Shelley Ching, Bridges, Arlene S., Bridges, Arlene S, Wang, Michael Z, Gem, Charles O, Michael Z Wang, Wolf, Kristina K, Wang, Michael Zhuo, Wolf, Kristina K., Ching, Shelley, Mutuku, James N., Arlene S Bridges, Boykin, David W, Murilla, Grace A, Murilla, Grace A., Qiang Liu, Paine, Mary F., Boykin, David W., Grace A Murilla, Jones, Susan K, Charles O Gem, James N Mutuku, Mary F Paine, Susan K Jones, Richard R Tidwell, Mutuku, James N, Paine, Mary F, David W Boykin, Liu, Qiang, Tidwell, Richard R., John K Thuita, Gem, Charles O., Kristina K Wolf, Jones, Susan K., Brun, Reto, Thuita, John K., Boykin, David, Reto Brun, Piane, Mary F., Tidwell, Richard R, Thuita, John K   +41 more
core   +2 more sources

In Vitro Mechanism of Action of Acanthospermum hispidum in Trypanosoma brucei

Advances in Pharmacological and Pharmaceutical Sciences, 2022
African trypanosomiasis is a major neglected tropical disease with significant health and economic concerns in sub-Saharan Africa. In the absence of vaccines for African trypanosomiasis, there is a consideration for alternative sources of chemotherapy ...
Aboagye Kwarteng Dofuor, Temitayo Samson Ademolue, Karen Nana Akua Kuampah, Frederick Ayertey, Theresa Manful Gwira   +4 more
doaj   +1 more source

Pharma to farmer: field challenges of optimizing trypanocide use in African animal trypanosomiasis.

Trends in Parasitology, 2021
Trypanocides are a key control component of African animal trypanosomiasis (AAT) in tsetse-infested areas of sub-Saharan Africa. While farmers are dependent upon trypanocides, recent research highlights their inappropriate and ineffective use, problems ...
Shauna Richards, L. Morrison, S. Torr, M. Barrett, Oliver Manangwa, F. Mramba, H. Auty   +6 more
semanticscholar   +1 more source

Focus–specific clinical profiles in human African trypanosomiasis caused by Trypanosoma brucei rhodesiense [PDF]

, 2010
<p><b>Background:</b> Diverse clinical features have been reported in human African trypanosomiasis (HAT) foci caused by <i>Trypanosoma brucei rhodesiense</i> (<i>T.b.rhodesiense</i>) giving rise to the ...
Odiit, Martin, Martin Odiit, Sternberg, J.M., Sternberg, Jeremy M, Peter G E Kennedy, MacLean, Lorna M, Chisi, J.E., Chisi, John, Peter G. E. Kennedy, Lorna M MacLean, Jeremy M Sternberg, John E. Chisi, Odiit, M., Kennedy, Peter, Kennedy, P.G.E., Jeremy M. Sternberg, Lorna M. MacLean, John E Chisi, MacLean, L.M.   +18 more
core   +2 more sources

Investigation on Prevalence of Canine Trypanosomiasis in the Conservation Areas of Bwindi-Mgahinga and Queen Elizabeth in Western Uganda

Journal of Parasitology Research, 2022
Nowadays, despite the instauration of several control strategies, animal trypanosomiasis continues to be reported all over Uganda. Few canine African trypanosomiasis (CAT) studies have been carried out, yet dogs are known Trypanosoma reservoirs that ...
James Robert Ochieng, Marta Planellas Bachs, Anthony Nsubuga, Innocent B. Rwego, John Joseph M. Kisakye, Laura Muro Riba, Jesus Muro Figueres   +6 more
doaj   +1 more source

Deciphering the Molecular Mechanism Underlying African Animal Trypanosomiasis by Means of the 1000 Bull Genomes Project Genomic Dataset

Biology, 2022
Simple Summary Climate change is increasing the risk of spreading vector-borne diseases such as African Animal Trypanosomiasis (AAT), which is causing major economic losses, especially in sub-Saharan African countries. Mainly considering this disease, we
A. Rajavel, Selina Klees, Yue-Han Hui, A. Schmitt, M. Gültas   +4 more
semanticscholar   +1 more source

A molecular mechanism for eflornithine resistance in African trypanosomes [PDF]

, 2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Creek, Darren, Burchmore, Richard J S, Vincent, Isabel M, Watson, David G, Barrett, Michael P, Kamleh, Mohammed A, Woods, Debra J, Wong, Pui Ee   +7 more
core   +5 more sources

Influence de la trypanosomose sur la reproduction des bovins en Afrique [PDF]

Tropicultura, 2000
The Influence of African Animal Trypanosomiasis on Reproduction of Cattle in Africa. The main effects of African animal Trypanosomiasis on reproduction of cattle have been reviewed.
Zecchini, M., Kageruka, P., De Deken, R.
doaj  

Anilinoquinoline based inhibitors of trypanosomatid proliferation.

PLoS Neglected Tropical Diseases, 2018
We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum.
Lori Ferrins, Amrita Sharma, Sarah M Thomas, Naimee Mehta, Jessey Erath, Scott Tanghe, Susan E Leed, Ana Rodriguez, Kojo Mensa-Wilmot, Richard J Sciotti, Kirsten Gillingwater, Michael P Pollastri   +11 more
doaj   +1 more source

African trypanosomes

Parasites & Vectors, 2019
African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa.
Mathieu Cayla, Federico Rojas, Eleanor Silvester, Frank Venter, Keith R. Matthews   +4 more
doaj   +1 more source