Results 61 to 70 of about 2,882,714 (182)

The burden and spatial distribution of bovine African trypanosomes in small holder crop-livestock production systems in Tororo District, south-eastern Uganda

Parasites & Vectors, 2014
Background African animal trypanosomiasis (AAT) is considered to be one of the greatest constraints to livestock production and livestock-crop integration in most African countries.
Dennis Muhanguzi, Kim Picozzi, Jan Hattendorf, Michael Thrusfield, John David Kabasa, Charles Waiswa, Susan Christina Welburn   +6 more
doaj   +1 more source

Potential impacts of climate change on geographical distribution of three primary vectors of African Trypanosomiasis in Tanzania's Maasai Steppe: G. m. morsitans, G. pallidipes and G. swynnertoni.

PLoS Neglected Tropical Diseases, 2021
In the Maasai Steppe, public health and economy are threatened by African Trypanosomiasis, a debilitating and fatal disease to livestock (African Animal Trypanosomiasis -AAT) and humans (Human African Trypanosomiasis-HAT), if not treated.
Happiness Jackson Nnko, Paul Simon Gwakisa, Anibariki Ngonyoka, Calvin Sindato, Anna Bond Estes   +4 more
doaj   +1 more source

Mathematical Model for Describing the Transmission of Animal African Trypanosomiasis in Cattle

Asian Research Journal of Mathematics
In this paper, we have formulated a mathematical model for the transmission dynamics of African Animal Trypanosomiasis (AAT) by incorporating spraying of the tsetse y population(vector) and treating the cattle population (host) as control strategies.
Conrad Akello, D. Ambogo, R. Opiyo
semanticscholar   +1 more source

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues

Journal of Medicinal Chemistry, 2023
While treatment options for human African trypanosomiasis (HAT) have improved significantly, there is still a need for new drugs with eradication now a realistic possibility.
Laura A. T. Cleghorn, Richard J. Wall, S. Albrecht, Stuart A. MacGowan, S. Norval, M. De Rycker, Andrew Woodland, D. Spinks, S. Thompson, Stephen Patterson, Victoriano Corpas Lopez, Gourav Dey, I. Collie, I. Hallyburton, Robert Kime, F. Simeons, L. Stojanovski, J. Frearson, P. Wyatt, K. Read, I. Gilbert, S. Wyllie   +21 more
semanticscholar   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Isothermal microcalorimetry – A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses.
M. Gysin, O. Braissant, K. Gillingwater, R. Brun, P. Mäser, T. Wenzler   +5 more
doaj   +1 more source

WHO target product profiles: four diagnostic tests needed in the effort to eliminate African trypanosomiasis

Bulletin of the World Health Organization, 2023
WHO target product profiles: four diagnostic tests needed in the effort to eliminate African trypanosomiasis Gerardo Priotto, José Ramón Franco Minguell, Veerle Lejon, Philippe Büscher, Enock Matovu, Joseph Ndung'u, Sylvain Biéler, Dieudonné Mumba, Nick ...
G. Priotto, J. Franco, V. Lejon, P. Büscher, E. Matovu, J. Ndung'u, S. Biéler, D. Mumba, N. Van Reet, P. Verlé, V. Jamonneau, P. Simarro, Augustin Kadima Ebeja, D. Sankara, D. Dagne   +14 more
semanticscholar   +1 more source

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

Collateral benefits of restricted insecticide application for control of African trypanosomiasis on Theileria parva in cattle: a randomized controlled trial [PDF]

, 2014
Tick and tsetse-borne diseases (TTBDs) constrain livestock production in tropical and subtropical regions of the world. Of this community of endemic diseases, East coast fever (T.parva) is the most important tick-borne disease (TBD) accounting for 70% of
Picozzi, Kim, Waiswa, Charles, Kabasa, John David, Jan Hatendorf, Dennis Muhanguzi, Susan Welburn, Charles Waiswa, John Kabasa, Thrusfield, Michael, Welburn, Susan Christina, Muhanguzi, Dennis, Michael Thrusfield, Hatendorf, Jan, Kim Picozzi   +13 more
core   +1 more source

Design of an Epitope-Based Vaccine Ensemble for Animal Trypanosomiasis by Computational Methods

Vaccines, 2020
African animal trypanosomiasis is caused by vector-transmitted parasites of the genus Trypanosoma. T. congolense and T. brucei brucei are predominant in Africa; T. evansi and T. vivax in America and Asia.
Lucas Michel-Todó, Pascal Bigey, Pedro A Reche, María-Jesus Pinazo, Joaquim Gascón, Julio Alonso-Padilla   +5 more
doaj   +1 more source