Results 71 to 80 of about 2,882,714 (182)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

A review on the diagnosis of animal trypanosomoses

Parasites & Vectors, 2022
This review focuses on the most reliable and up-to-date methods for diagnosing trypanosomoses, a group of diseases of wild and domestic mammals, caused by trypanosomes, parasitic zooflagellate protozoans mainly transmitted by insects.
Marc Desquesnes, Marisa Gonzatti, Alireza Sazmand, Sophie Thévenon, Géraldine Bossard, Alain Boulangé, Geoffrey Gimonneau, Philippe Truc, Stéphane Herder, Sophie Ravel, Denis Sereno, Vincent Jamonneau, Sathaporn Jittapalapong, Philippe Jacquiet, Philippe Solano, David Berthier   +15 more
doaj   +1 more source

Genomic Occupancy of the Bromodomain Protein Bdf3 Is Dynamic during Differentiation of African Trypanosomes from Bloodstream to Procyclic Forms

mSphere, 2022
Trypanosoma brucei, the causative agent of human and animal African trypanosomiasis, cycles between a mammalian host and a tsetse fly vector. The parasite undergoes huge changes in morphology and metabolism during adaptation to each host environment ...
Ethan Ashby, Lucinda Paddock, Hannah L. Betts, Jingwen Liao, Geneva Miller, Anya Porter, Lindsey M. Rollosson, Carrie Saada, Eric Tang, Serenity J. Wade, Johanna Hardin, Danae Schulz   +11 more
doaj   +1 more source

Modelling to infer the role of animals in gambiense human African trypanosomiasis transmission and elimination in the DRC

PLoS Neglected Tropical Diseases, 2022
Gambiense human African trypanosomiasis (gHAT) has been targeted for elimination of transmission (EoT) to humans by 2030. Whilst this ambitious goal is rapidly approaching, there remain fundamental questions about the presence of non-human animal ...
R. E. Crump, Ching-I Huang, S. Spencer, P. Brown, Chansy Shampa, Erick Mwamba Miaka, K. S. Rock   +6 more
semanticscholar   +1 more source

Atlantic trade and the West African market economy: New evidence from cowry imports, 1650–1905

The Economic History Review, EarlyView.
Abstract Between the seventeenth and twentieth centuries, billions of cowries arrived in West Africa, leaving one of the few quantitative traces available for historians to measure the Atlantic trade's impact on the precolonial market economy. Yet, current estimates substantially underestimate the volume of cowry imports.
María José Pont Cháfer
wiley   +1 more source

A murine model of Trypanosoma brucei-induced myocarditis and cardiac dysfunction

Microbiology Spectrum
Trypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). Cardiac symptoms are commonly reported in HAT patients, and intracardiac parasites with accompanying myocarditis have been observed in both ...
Nathan P. Crilly, Marcelle Dina Zita, Alexander K. Beaver, Polina Sysa-Shah, Aashik Bhalodia, Kathy Gabrielson, Luigi Adamo, Monica R. Mugnier   +7 more
doaj   +1 more source

Wing Interferential Patterns (WIPs) and machine learning, a step toward automatized tsetse (Glossina spp.) identification

Scientific Reports, 2022
A simple method for accurately identifying Glossina spp in the field is a challenge to sustain the future elimination of Human African Trypanosomiasis (HAT) as a public health scourge, as well as for the sustainable management of African Animal ...
Arnaud Cannet, Camille Simon-Chane, Mohammad Akhoundi, Aymeric Histace, Olivier Romain, Marc Souchaud, Pierre Jacob, Pascal Delaunay, Darian Sereno, Philippe Bousses, Pascal Grebaut, Anne Geiger, Chantel de Beer, Dramane Kaba, Denis Sereno   +14 more
doaj   +1 more source

Local Solutions to Structural Issues: The Fetishization of Custom in Rural Development Interventions in Côte d'Ivoire

Journal of Agrarian Change, EarlyView.
ABSTRACT This paper explores the paradox of seeking local solutions in rural development when conflicts result from structural transformations of the agrarian economy driven by national political choices. Since the 1990s, participatory approaches inspired by neo‐institutionalist theories of local governance have encouraged development actors to view ...
Toni‐Giovanni Pegurri
wiley   +1 more source

In Vitro and In Vivo Trypanocidal Efficacy of Synthesized Nitrofurantoin Analogs

Molecules, 2021
African trypanosomes cause diseases in humans and livestock. Human African trypanosomiasis is caused by Trypanosoma brucei rhodesiense and T. b. gambiense.
Linous Munsimbwe, Anna Seetsi, Boniface Namangala, David D. N’Da, Noboru Inoue, Keisuke Suganuma   +5 more
doaj   +1 more source

Garlic‐Derived Behavioural Deterrents: Diallyl Disulfide and TrpA1‐Mediated Suppression of Insect Reproduction

Modern Agriculture, Volume 4, Issue 2, December 2026.
Garlic‐derived diallyl disulfide acts as a behavioural deterrent that suppresses insect mating and oviposition through sensory pathways. The compound is detected through gustatory mechanisms involving the transient receptor potential A1 (TrpA1) channel and neural responses.
Sumit Singh, Shaoying Wu
wiley   +1 more source