Results 81 to 90 of about 2,882,714 (182)

Experiences of the one-health approach by the Uganda Trypanosomiasis Control Council and its secretariat in the control of zoonotic sleeping sickness in Uganda

Parasite Epidemiology and Control, 2020
Elimination of sleeping sickness from endemic countries like Uganda is key if the affected communities are to exploit the potential of the available human and livestock resources (production and productivity). Trypanosoma brucei rhodesiense, the parasite
C. Waiswa, R. Azuba, J. Makeba, I.C. Waiswa, R.M. Wangoola   +4 more
doaj   +1 more source

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

Nature Communications, 2021
The parasitic protist Trypanosoma brucei is the causative agent of Human African Trypanosomiasis, also known as sleeping sickness. The parasite enters the blood via the bite of the tsetse fly where it is wholly reliant on glycolysis for the production of
I. McNae, James Kinkead, Divya Malik, Lily Yen, Martin K. Walker, Chris Swain, S. Webster, N. Gray, P. Fernandes, E. Myburgh, E. Blackburn, Ryan Ritchie, C. Austin, M. Wear, A. Highton, A. Keats, A. Vong, J. Dornan, J. Mottram, P. Michels, S. Pettit, M. Walkinshaw   +21 more
semanticscholar   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

Immunodiagnosis of bovine trypanosomiasis in Anambra and Imo states, Nigeria, using enzyme-linked immunosorbent assay: zoonotic implications to human health [PDF]

Journal of Vector Borne Diseases, 2008
Background & objectives: The prevalence of trypanosomiasis was studied in cattle, being a major source of animal protein in Nigeria, thus, a very likely means of spread of Human African Trypano-somosis (HAT).
M.C. Ezeani, H. Okoro, V.O. Anosa, C.C. Onyenekwe, S.C. Meludu, C.E. Dioka, C.C. Azikiwe   +6 more
doaj  

Past and Ongoing Tsetse and Animal Trypanosomiasis Control Operations in Five African Countries: A Systematic Review.

PLoS Neglected Tropical Diseases, 2016
BackgroundControl operations targeting Animal African Trypanosomiasis and its primary vector, the tsetse, were covering approximately 128,000 km2 of Africa in 2001, which is a mere 1.3% of the tsetse infested area.
Anne Meyer, Hannah R Holt, Richard Selby, Javier Guitian   +3 more
doaj   +1 more source

Prevalence of trypanosomes associated with drug resistance in Shimba Hills, Kwale County, Kenya

BMC Research Notes, 2020
Objective Animal African trypanosomiasis (AAT) is a life-threatening vector-borne disease, caused by trypanosome parasites, which are principally transmitted by tsetse flies.
Benard W. Kulohoma, Sarah A. O. Wamwenje, Ibrahim I. Wangwe, Nicodemus Masila, Caroline K. Mirieri, Lillian Wambua   +5 more
doaj   +1 more source

Knowledge, Attitude, and Practice of Livestock Owners and Livestock Assistants towards African Trypanosomiasis Control in The Gambia

Journal of Parasitology Research, 2022
Background In Africa, it has been estimated that 50 million cattle and 70 million sheep and goats are at risk of animal African trypanosomiasis, and three million cattle die annually.
Alpha Kargbo, Edrisa Jawo, Amien Isaac Amoutchi, H. Koua, Rex A. Kuye, Zaïnabou Dabré, A. Bojang, R. F. Vieira   +7 more
semanticscholar   +1 more source

Survey of Smallholder Dairy Cattle Farming System and Antibiotic Residues in Raw Cow's Milk in Bagamoyo District, Tanzania

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Smallholder dairy farmers in Tanzania face livestock disease challenges that drive imprudent antimicrobial use and fuel antimicrobial resistance (AMR). In Bagamoyo, poor husbandry and limited disease control result in high prevalence of vector‐borne infections, commonly treated with oxytetracycline (OTC).
Ridhiwan I. Ramadhani, Hezron Emmanuel Nonga   +1 more
wiley   +1 more source

Profiling Major Livestock Diseases in the East Gojjam Zone, Amhara Region, Ethiopia, Using Participatory Epidemiology Methods

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Participatory epidemiology identified CBPP, LSD, FMD and sheep/goat pox as the major livestock diseases in East Gojjam, Ethiopia, highlighting strong community‐based disease recognition and emphasizing the value of integrating local knowledge into veterinary surveillance and disease control systems.
Liuel Yizengaw Adnie, Haregua Yesigat, Arega Tafere, Kifle Wondimagegnehu, Dessalew Habte, Natenael Teshager, Habtamu Yalew Ayenew, Fentahun Shitaw   +7 more
wiley   +1 more source

Identification of New Anti‐Trypanosoma brucei Leads: An Integrated CRK12‐Guided Virtual Screen With Experimental Validation

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
An integrated computational‐experimental workflow enabled CRK12‐guided hit discovery against Trypanosoma brucei under limited structural and ligand data. The workflow of virtual screening and anti‐T. brucei bioassays identified 4 hit compounds, including three low‐micromolar leads (IC50 = 1.47, 0.81, and 1.33 μM). ABSTRACT Human African trypanosomiasis
Qin Li, Chenggong Fu, Jiayi Luo, Qianqian Zhang, Lingling Wang, Xiaomeng Liu, Jiayue Qiu, Xiaoqing Gong, Henry H. Y. Tong, Xiaojun Yao, Dehua Lai, Huanxiang Liu   +11 more
wiley   +1 more source