Results 91 to 100 of about 2,882,714 (182)

Pharmacological investigations on current and new drugs for treatment of human African trypanosomiasis [PDF]

, 1999
Trypanosomiasis remains a major threat to humans in sub-Saharan Africa with 55-60 million people in 36 countries at risk of infection with T.b. gambiense or T.b. rhodesiense.
Keiser, Jennifer
core   +1 more source

N-(Isobutyl)-3,4-methylenedioxy Cinnamoyl Amide

Molbank, 2019
The plant Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler is one of the most important medicinal species of the genus Zanthoxylum on the African continent.
Aboagye Kwarteng Dofuor, Samuel Kwain, Enoch Osei, Gilbert Mawuli Tetevi, Laud Kenneth Okine, Mitsuko Ohashi, Theresa Manful Gwira, Kwaku Kyeremeh   +7 more
doaj   +1 more source

Bovines, buffers and barriers: A social scientific perspective on rewilding in the Kavango‐Zambezi Transfrontier Conservation Area

Conservation Science and Practice, Volume 8, Issue 9, September 2026.
Rewilding is often summarized with the three C's of Carnivores, Cores and Corridors. In this essay we propose a complementary perspective that focuses on the three B's of Bovines, Buffers and Barriers. This complementary perspective draws attention to rewilding as a social (rather than only ecological) challenge and is illustrated with insights from ...
Wisse Van Engelen, Paula Alexiou, Manuel Bollmann, Julia Brekl, Emilie Köhler, Léa Lacan, Hauke‐Peter Vehrs, Michael Bollig   +7 more
wiley   +1 more source

Molecular epidemiological studies on animal trypanosomiases in Ghana

Parasites & Vectors, 2012
Background African trypanosomes are extracellular protozoan parasites that are transmitted between mammalian hosts by the bite of an infected tsetse fly. Human African Trypanosomiasis (HAT) or sleeping sickness is caused by Trypanosoma brucei rhodesiense
Nakayima Jesca, Nakao Ryo, Alhassan Andy, Mahama Charles, Afakye Kofi, Sugimoto Chihiro   +5 more
doaj   +1 more source

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

Studies of trypanosomiasis in the Luangwa valley, north-eastern Zambia

Parasites & Vectors, 2015
Background The present study, conducted in Zambia’s Luangwa valley where both animal African trypanosomiasis (AAT) and human African trypanosomiasis (HAT) are endemic, combined the use of microscopy and molecular techniques to determine the presence of ...
Dusit Laohasinnarong, Yasuhuki Goto, Masahito Asada, Ryo Nakao, Kyoko Hayashida, Kiichi Kajino, Shin-ichiro Kawazu, Chihiro Sugimoto, Noboru Inoue, Boniface Namangala   +9 more
doaj   +1 more source

Exploring the effect of human and animal population growth on vector-borne disease transmission with an agent-based model of Rhodesian human African trypanosomiasis in eastern province, Zambia

PLoS Neglected Tropical Diseases, 2018
This paper presents the development of an agent-based model (ABM) to investigate Trypanosoma brucei rhodesiense human African trypanosomiasis (rHAT) disease transmission.
S. Alderton, E. Macleod, N. Anderson, N. Machila, M. Simuunza, S. Welburn, P. Atkinson   +6 more
semanticscholar   +1 more source

Translocation of livestock‐raiding lions under specific conditions can mitigate conflict

Conservation Science and Practice, Volume 8, Issue 8, August 2026.
Human‐wildlife conflict is a pervasive threat that imperils many carnivore species worldwide, and although translocation is often used as a conflict mitigation strategy, it is widely regarded as ineffective. Here, we demonstrate that careful selection of suitable release sites can improve outcomes, as 80% of stock‐raiding lion translocations in ...
Willem D. Briers‐Louw, João Almeida, Carlos Lopes Pereira, Hugo Pereira, Hagnésio Chiponde, Peter Lindsey, Tamar Kendon, Dário Ngalijuane, Holly Rosier, Jo Taylor, Ellery Worth, Marnus Roodbol, Eugenio Manhiça, David Gaynor, Alison Leslie, Vincent N. Naude   +15 more
wiley   +1 more source

The natural progression of gambiense sleeping sickness: what is the evidence? [PDF]

, 2008
Gambiense human African trypanosomiasis (HAT, sleeping sickness) is widely assumed to be 100% pathogenic and fatal. However, reports to the contrary exist, and human trypano-tolerance has been postulated.
Filipe, João AN, Francesco Checchi, Barrett, M.P., Daniel Chandramohan, Checchi Francesco, Barrett, Michael P, Checchi, Francesco, Filipe, J.A.N., Chandramohan, Daniel, João A N Filipe, Barrett Michael P., Michael P Barrett, Filipe João A. N., Checchi, F., Chandramohan, D., Chandramohan Daniel   +15 more
core   +2 more sources

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source