Results 21 to 30 of about 2,882,714 (182)

Current Treatments to Control African Trypanosomiasis and One Health Perspective

Microorganisms, 2022
Human African Trypanosomiasis (HAT, sleeping sickness) and Animal African Trypanosomiasis (AAT) are neglected tropical diseases generally caused by the same etiological agent, Trypanosoma brucei.
Alberto Venturelli, Lorenzo Tagliazucchi, Clara Lima, Federica Venuti, Giulia Malpezzi, George E. Magoulas, Nuno Santarem, Theodora Calogeropoulou, Anabela Cordeiro-da-Silva, Maria Paola Costi   +9 more
doaj   +2 more sources

Restricted insecticide application: a last mile control option for elimination of acute sleeping sickness and progressive control of African animal trypanosomiasis in South-Eastern Uganda [PDF]

BMC Veterinary Research
Background Animal African trypanosomiasis (AAT) poses a significant impediment to livestock production and economic progress in sub-Saharan Africa. To reduce the burden of AAT in Uganda and contribute to the AAT progressive control pathway, there is a ...
Dennis Muhanguzi, Auther Tamale Wasswa, Patrick P’Odyek Abila, Albert Mugenyi, Mesearch Kakuru, Harriet Abizera, Solomon Ainebyoona, Marvyn Kansiime, Wilson Amanyire, Joseph Nkamwesiga, Phillip Magambo Kimuda, Karla Rascón-García, Enock Matovu   +12 more
doaj   +2 more sources

Expanding the applications of a bioluminescent mouse infection model of acute African trypanosomiasis

Frontiers in Chemical Biology
IntroductionIn vivo imaging technology based on bioluminescence has contributed to the study of different pathophysiological conditions involving inherited or transmissible diseases.
Diego Benítez, Cecilia Ortíz, Estefania Dibello, Estefania Dibello, Marcelo A. Comini   +4 more
doaj   +2 more sources

Geospatial Analysis of Tsetse Infestation and Animal African Trypanosomiasis in Busia County, Kenya [PDF]

Journal of Parasitology Research
African trypanosomiasis (AT) is a vector-borne disease caused by protozoan parasites of the genus Trypanosoma, primarily transmitted through the bite of infected tsetse flies in the genus Glossina.
S. S. Burudi, P. O. Mudavadi, J. K. Cheruiyot, E. O. Mungube   +3 more
doaj   +2 more sources

Probing 5-Nitroimidazole-Triazole Hybrids as Potential Anti-Kinetoplastid Agents: Synthesis and In Vitro Efficacy. [PDF]

ChemMedChem
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Ferreira L, Badenhorst GD, Aucamp J, Suganuma K, N'Da DD.   +4 more
europepmc   +2 more sources

The use of Multiple Displacement Amplification to increase the detection and genotyping of Trypanosoma samples immobilised on FTA filters. [PDF]

, 2007
Whole genome amplification methods are a recently developed tool for amplifying DNA from limited template. We report its application in trypanosome infections, characterized by low parasitemias.
Sweeney, L., Turner, C.M.R., Morrison, L.J., Likeufack, A.C.L., Truc, P., Tait, A., McCormack, G., MacLeod, A.   +7 more
core   +8 more sources

Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts

Virulence, 2023
African trypanosomes are vector-borne protozoa, which cause significant human and animal disease across sub-Saharan Africa, and animal disease across Asia and South America.
Liam J. Morrison, Pieter C. Steketee, Mabel D. Tettey, Keith R. Matthews   +3 more
doaj   +1 more source

Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis. [PDF]

PLoS Neglected Tropical Diseases, 2013
Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this ...
Jan Medlock, Katherine E Atkins, David N Thomas, Serap Aksoy, Alison P Galvani   +4 more
doaj   +1 more source

Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance

Tropical Medicine and Infectious Disease, 2022
Background: African trypanocide resistance is an emerging public health emergency whose control requires a revisit on farmer’s knowledge, attitudes, and practices in developing countries.
Keneth Iceland Kasozi, Ewan Thomas MacLeod, Charles Waiswa, Michael Mahero, Ibrahim Ntulume, Susan Christina Welburn   +5 more
doaj   +1 more source

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human african trypanosomiasis [PDF]

, 2011
Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites Trypanosoma brucei (T.b.) gambiense or T.b.rhodesiense and is invariably fatal if untreated.
McCabe, C., Jones, A., Kennedy, P. G. E., Gibaud, S., Barrett, M. P., Rodgers, J., Bradley, B., Gettinby, G.   +7 more
core   +5 more sources