Results 21 to 30 of about 13,726 (210)

APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

eLife, 2017
Reduced susceptibility to infectious disease can increase the frequency of otherwise deleterious alleles. In populations of African ancestry, two apolipoprotein-L1 (APOL1) variants with a recessive kidney disease risk, named G1 and G2, occur at high ...
Anneli Cooper, Hamidou Ilboudo, V Pius Alibu, Sophie Ravel, John Enyaru, William Weir, Harry Noyes, Paul Capewell, Mamadou Camara, Jacqueline Milet, Vincent Jamonneau, Oumou Camara, Enock Matovu, Bruno Bucheton, Annette MacLeod   +14 more
doaj   +1 more source

Human African trypanosomiasis

BMJ, 2002
The re-emergence of sleeping sickness presents a major public health problem Human African trypanosomiasis or sleeping sickness is one of the most important but equally most neglected tropical infections. It is caused by a protozoan, Trypanosoma brucei ,which is transmitted to humans through the bite of a tsetse fly ( Glossina spp).1 Patchy ...
August, Stich, Paulo M, Abel, Sanjeev, Krishna   +2 more
openaire   +3 more sources

Focus–specific clinical profiles in human African trypanosomiasis caused by Trypanosoma brucei rhodesiense [PDF]

, 2010
<p><b>Background:</b> Diverse clinical features have been reported in human African trypanosomiasis (HAT) foci caused by <i>Trypanosoma brucei rhodesiense</i> (<i>T.b.rhodesiense</i>) giving rise to the ...
Odiit, Martin, Martin Odiit, Sternberg, J.M., Sternberg, Jeremy M, Peter G E Kennedy, MacLean, Lorna M, Chisi, J.E., Chisi, John, Peter G. E. Kennedy, Lorna M MacLean, Jeremy M Sternberg, John E. Chisi, Odiit, M., Kennedy, Peter, Kennedy, P.G.E., Jeremy M. Sternberg, Lorna M. MacLean, John E Chisi, MacLean, L.M.   +18 more
core   +1 more source

The history of African trypanosomiasis

Parasites & Vectors, 2008
The prehistory of African trypanosomiasis indicates that the disease may have been an important selective factor in the evolution of hominids. Ancient history and medieval history reveal that African trypanosomiasis affected the lives of people living in
Steverding Dietmar
doaj   +1 more source

A literature review of economic evaluations for a neglected tropical disease : human African trypanosomiasis ("sleeping sickness") [PDF]

, 2015
Human African trypanosomiasis (HAT) is a disease caused by infection with the parasite Trypanosoma brucei gambiense or T. b. rhodesiense. It is transmitted to humans via the tsetse fly.
Sutherland, C. S., Joshua Yukich, Tediosi, F., C. Simone Sutherland (689448), C Simone Sutherland, Ron Goeree (201687), Fabrizio Tediosi (247282), TEDIOSI, FABRIZIO, Ron Goeree, Goerre, R., Yukich, Joshua, Sutherland, C. Simone, Yukich, J., C. Simone Sutherl, Fabrizio Tediosi, Joshua Yukich (44606), Goeree, Ron   +16 more
core   +1 more source

Molecular epidemiological studies on animal trypanosomiases in Ghana

Parasites & Vectors, 2012
Background African trypanosomes are extracellular protozoan parasites that are transmitted between mammalian hosts by the bite of an infected tsetse fly. Human African Trypanosomiasis (HAT) or sleeping sickness is caused by Trypanosoma brucei rhodesiense
Nakayima Jesca, Nakao Ryo, Alhassan Andy, Mahama Charles, Afakye Kofi, Sugimoto Chihiro   +5 more
doaj   +1 more source

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis [PDF]

, 2011
Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is ...
Jones, A., Michael P. Barrett, Peter G E Kennedy, Bradley Barbara, Bradley, Barbara, Barrett, M. P., McCabe Christopher, Peter G. E. Kennedy, Bradley, B., Rodgers, Jean, Gettinby, George, Gettinby George, Kennedy Peter G. E., McCabe, Chris, Amy Jones, Kennedy, Peter G. E., Barrett, Michael P., Michael P Barrett, Kennedy, Peter G.E., George Gettinby, Gibaud, Stephane, Barbara Bradley, McCabe, C., Mccabe, Christopher, Jean Rodgers, Kennedy, P. G. E., Gibaud, S., Stéphane Gibaud, Rodgers, J., Rodgers Jean, Jones Amy, Jones, Amy, Christopher McCabe, Barrett Michael P., Gibaud Stéphane, Gettinby, G.   +35 more
core   +1 more source

Prevalence and under-detection of gambiense human African trypanosomiasis during mass screening sessions in Uganda and Sudan [PDF]

, 2012
BACKGROUND: Active case detection through mass community screening is a major control strategy against human African trypanosomiasis (HAT, sleeping sickness) caused by T. brucei gambiense.
Haydon Daniel T, Chappuis, F., Cox, A.P., Cox Andrew P, Checchi Francesco, Haydon, D.T., Priotto Gerardo, Priotto, Gerardo, Checchi, Francesco, Chandramohan, Daniel, Priotto, G., Haydon, Daniel T, Cox, Andrew P, Checchi, F., Chandramohan, D., Chappuis, François, Chappuis François, Chandramohan Daniel   +17 more
core   +1 more source

Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis [PDF]

, 2013
There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs of HAT.
Arlene S. Bridges (301008), Shelley Ching, Bridges, Arlene S., Raymond E Mdachi, Brun Reto, Wang Michael Zhuo, Wang, Michael Zhuo, Wolf, Kristina K., Ching, Shelley, Arlene S Bridges, Mutuku James N., Murilla, Grace A., Paine, Mary F., Boykin, David W., James N Mutuku, Richard R Tidwell, Mohamed A Ismail, John K. Thuita (148377), Liu, Qiang, Tidwell, Richard R., Hall, James E., Mary F. Paine (148396), John K Thuita, Bridges Arlene S., Ismail Mohamed A., Mdachi, Raymond E., Qiang Liu (166143), Mdachi Raymond E., David W. Boykin (148406), Reto Brun, Reto Brun (41511), Ching Shelley, Hall, James Edwin, Shelley Ching (148404), Tidwell Richard R., Chen, Yao, Mohamed A. Ismail (418629), Boykin David W., Mutuku, James N., James Edwin Hall, Qiang Liu, Grace A Murilla, Hall James Edwin, Raymond E. Mdachi (148398), Mary F Paine, Liu Qiang, Kristina K. Wolf (418627), Michael Zhuo Wang, Thutia, John K., David W Boykin, Yao Chen (149006), Grace A. Murilla (148401), Ismail, Mohamed A., Michael Zhuo Wang (418631), Murilla Grace A., Wolf Kristina K., Kristina K Wolf, James Edwin Hall (418630), Thuita John K., James N. Mutuku (418628), Brun, Reto, Yao Chen, Thuita, John K., Richard R. Tidwell (148409), Paine Mary F., Chen Yao   +65 more
core   +1 more source

Sleeping Sickness at the Crossroads

Tropical Medicine and Infectious Disease, 2020
Human African trypanosomiasis (HAT; sleeping sickness) is a disease with truly historic dimensions [...]
Christian Burri
doaj   +1 more source