Results 1 to 10 of about 1,501,860 (182)

Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

eLife
African trypanosomes are the causative agents of neglected tropical diseases affecting both humans and livestock. Disease control is highly challenging due to an increasing number of drug treatment failures.
Joar Esteban Pinto Torres, Mathieu Claes, Rik Hendrickx, Meng Yuan, Natalia Smiejkowska, Pieter Van Wielendaele, Aysima Hacisuleyman, Hans De Winter, Serge Muyldermans, Paul AM Michels, Malcolm D Walkinshaw, Wim Versées, Guy Caljon, Stefan Magez, Yann G-J Sterckx   +14 more
doaj   +1 more source

Ligand-Based Virtual Screening and Molecular Docking of Benzimidazoles as Potential Inhibitors of Triosephosphate Isomerase Identified New Trypanocidal Agents. [PDF]

Int J Mol Sci, 2022
Vázquez-Jiménez LK, Juárez-Saldivar A, Gómez-Escobedo R, Delgado-Maldonado T, Méndez-Álvarez D, Palos I, Bandyopadhyay D, Gaona-Lopez C, Ortiz-Pérez E, Nogueda-Torres B, Ramírez-Moreno E, Rivera G.   +11 more
europepmc   +1 more source

Evaluating 5-nitrothiazoles as trypanocidal agents

, 2013
s.r.wilkinson@qmul.ac ...
Bot, Christopher, Hall, Belinda S., Alvarez, Guzman, Di Maio, Rossanna, Gonzalez, Mercedes, Cerecetto, Hugo, Wilkinson, Shane R.   +6 more
openaire   +2 more sources

[Introduction of changes in the DNA of Trypanosoma cruzi by trypanocidal agents].

Revista Argentina de microbiologia, 1989
Incubation of Trypanosoma cruzi culture (epimastigote) forms with nifurtimox (10 or 100 microM), benznidazole (38 or 380 microM) and beta-lapachone (1.6 or 7.8 microM) produced damage of nuclear DNA, as shown by the increased rate of the "unscheduled DNA synthesis" in epimastigotes arrested at phase S (9-, 3-, and 6-fold, respectively). alpha-lapachone,
S G, Goijman, A C, Frasch, A O, Stoppani
openaire   +1 more source

Further Studies on the Antiparasitic Activity of Quinoxaline-1,4-di-N-Oxides Containing a Glycine Side Chain

Parasitologia
Chagas disease and trichomoniasis are two neglected parasitic infections (NPIs) in need for new therapies that address both the toxicity and limited bioavailability impacting on the effectiveness of benznidazole (BZ) and nifurtimox, the only drugs ...
Manuel Lacueva-Arnedo, Teresa Espinosa-Buitrago, Lena Huck, Juan F. González, J. Carlos Menéndez, Alexandra Ibáñez-Escribano, Cristina Fonseca-Berzal   +6 more
doaj   +1 more source

Insights into Chagas treatment based on the potential of bacteriocin AS-48

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Chagas disease caused by the protozoan parasite Trypanosoma cruzi represents a significant public health problem in Latin America, affecting around 8 million cases worldwide.
Rubén Martín-Escolano, Rubén Cebrián, Javier Martín-Escolano, Maria J. Rosales, Mercedes Maqueda, Manuel Sánchez-Moreno, Clotilde Marín   +6 more
doaj   +1 more source

Synthesis of Novel Acetamidobenzanilides Derivatives as Potencial Trypanocidal Agents

Abstract A simple synthesis of novel N-(2-[N’-acetamidomethyl])benzanilides derivatives from 2-nitrobenzaldehyde in a four steps process is described. The 1H-NMR and 13C-NMR spectra were meticulously analyzed to characterize their structure and it was observed that derivatives with an ortho-substituted phenyl group exhibited detectable ...
Valentín I. Ortellado, Carlos U. Molfesa Kaczoruk, Lucio A. Guaymas, Emmanuele Parisi, Guido G. Fraga, Gisela C. Muscia, Fernanda M. Frank, Ana M. Bruno, Agustı́n Ponzinibbio, Leandro D. Sasiambarrena   +9 more
openaire   +1 more source

Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and Trypanosoma cruzi Amastigotes

Pharmaceuticals
Background: Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both ...
Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca , Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima   +18 more
doaj   +1 more source

Identification of Potential Trypanosoma cruzi Trans-Sialidase Inhibitors by Computational Drug Repositioning Approaches

Scientia Pharmaceutica
Chagas disease, caused by the parasitic protozoan Trypanosoma cruzi (T. cruzi), represents a worldwide public health issue. To date, there is no efficient treatment to combat this pathology, and the only drugs available are usually toxic to the patient ...
Miguel A. Uc-Chuc, Nohemi Cigarroa-Toledo, Karla Y. Acosta-Viana, José I. Chan-Pérez, Juan C. Pineda-Cortes, Hernán de J. Villanueva-Alonzo   +5 more
doaj   +1 more source

Gossypol: a potential trypanocidal agent [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 1985
openaire   +3 more sources