Results 1 to 10 of about 32,421 (180)

Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids

Frontiers in Cellular and Infection Microbiology, 2022
Chagas disease is an endemic American parasitosis, caused by Trypanosoma cruzi. The current therapies, benznidazole (BZN) and nifurtimox (NFX), show limited efficacy and multiple side effects. Thus, there is a need to develop new trypanocidal strategies.
Laura Fraccaroli, María Daniela Ruiz, Virginia Gabriela Perdomo, Agustina Nicole Clausi, Darío Emmanuel Balcazar, Luciana Larocca, Carolina Carrillo   +6 more
doaj   +1 more source

Repurposing Carvedilol as a Novel Inhibitor of the Trypanosoma cruzi Autophagy Flux That Affects Parasite Replication and Survival

Frontiers in Cellular and Infection Microbiology, 2021
T. cruzi, the causal agent of Chagas disease, is a parasite able to infect different types of host cells and to persist chronically in the tissues of human and animal hosts.
Cynthia Vanesa Rivero, Cynthia Vanesa Rivero, Santiago José Martínez, Santiago José Martínez, Paul Novick, Juan Agustín Cueto, Betiana Nebaí Salassa, María Cristina Vanrell, Xiaomo Li, Carlos Alberto Labriola, Luis Mariano Polo, David M. Engman, Joachim Clos, Patricia Silvia Romano   +13 more
doaj   +1 more source

Biological features of TcM: A new Trypanosoma cruzi isolate from Argentina classified into TcV lineage

Current Research in Microbial Sciences, 2022
Trypanosoma cruzi, the etiologic agent of Chagas disease (CD) presents a wide genetic and phenotypic diversity that is classified into seven lineages or discrete typing units (DTU: TcI to TcVI and Tcbat).
Santiago José Martinez, Gonzalo Nicolás Nardella, Matías Exequiel Rodríguez, Cynthia Vanesa Rivero, Fernán Agüero, Patricia Silvia Romano   +5 more
doaj   +1 more source

Induction of Autophagy by Ursolic Acid Promotes the Elimination of Trypanosoma cruzi Amastigotes From Macrophages and Cardiac Cells

Frontiers in Cellular and Infection Microbiology, 2022
Chagas disease, caused by the parasite Trypanosoma cruzi, is an infectious illness endemic to Latin America and still lacks an effective treatment for the chronic stage.
María Cristina Vanrell, María Cristina Vanrell, Santiago José Martinez, Lucila Ibel Muñoz, Betiana Nebaí Salassa, Betiana Nebaí Salassa, Julián Gambarte Tudela, Patricia Silvia Romano, Patricia Silvia Romano   +8 more
doaj   +1 more source

Alpha-Tubulin Acetylation in Trypanosoma cruzi: A Dynamic Instability of Microtubules Is Required for Replication and Cell Cycle Progression

Frontiers in Cellular and Infection Microbiology, 2021
Trypanosomatids have a cytoskeleton arrangement that is simpler than what is found in most eukaryotic cells. However, it is precisely organized and constituted by stable microtubules.
Victoria Lucia Alonso, Victoria Lucia Alonso, Mara Emilia Carloni, Camila Silva Gonçalves, Camila Silva Gonçalves, Gonzalo Martinez Peralta, Gonzalo Martinez Peralta, Maria Eugenia Chesta, Alejandro Pezza, Luis Emilio Tavernelli, Maria Cristina M. Motta, Maria Cristina M. Motta, Esteban Serra, Esteban Serra   +13 more
doaj   +1 more source

Endocytic Rabs Are Recruited to the Trypanosoma cruzi Parasitophorous Vacuole and Contribute to the Process of Infection in Non-professional Phagocytic Cells

Frontiers in Cellular and Infection Microbiology, 2020
Trypanosoma cruzi is the parasite causative of Chagas disease, a highly disseminated illness endemic in Latin-American countries. T. cruzi has a complex life cycle that involves mammalian hosts and insect vectors both of which exhibits different ...
Betiana Nebaí Salassa, Betiana Nebaí Salassa, Juan Agustín Cueto, Juan Agustín Cueto, Julián Gambarte Tudela, Patricia Silvia Romano, Patricia Silvia Romano   +6 more
doaj   +1 more source

Acute Phase Proteins in Dogs with Natural Infection by Trypanosoma cruzi

Tropical Medicine and Infectious Disease, 2023
Acute phase proteins have been used as tools for the diagnosis, monitoring, and prognosis of several diseases in domestic animals. However, the dynamics of these proteins in infection by Trypanosoma cruzi, the causative agent of Chagas disease in dogs ...
Pilar Rivadeneira-Barreiro, Roberto Montes-de-Oca-Jiménez, Pablo Zambrano-Rodríguez, Juan Carlos Vázquez-Chagoyán, Adriana del Carmen Gutiérrez-Castillo, Luis Pardo-Marin, Lorena Franco-Martínez, José Joaquín Cerón, Silvia Martínez-Subiela   +8 more
doaj   +1 more source

Precision Health for Chagas Disease: Integrating Parasite and Host Factors to Predict Outcome of Infection and Response to Therapy

Frontiers in Cellular and Infection Microbiology, 2020
Chagas disease, caused by the infection with the protozoan parasite Trypanosoma cruzi, is clinically manifested in approximately one-third of infected people by inflammatory heart disease (cardiomyopathy) and, to a minor degree, gastrointestinal tract ...
Santiago J. Martinez, Santiago J. Martinez, Patricia S. Romano, David M. Engman, David M. Engman, David M. Engman   +5 more
doaj   +1 more source

Flagellar pocket receptors as entry point for protein-based drugs against kinetoplastid parasites [PDF]

Exploration of Drug Science
Aim: Kinetoplastids are flagellated protozoa encompassing multiple parasitic species responsible for severe neglected diseases. Although treatments exist, therapeutic failure and toxic side effects underscore the need for innovative drug development ...
Lucila Attala, Cecilia Vernetti, Elvio Rodríguez Araya   +2 more
doaj   +1 more source

Phylogenetic analysis of Bolivian bat trypanosomes of the subgenus schizotrypanum based on cytochrome B sequence and minicircle analyses. [PDF]

PLoS ONE, 2012
The aim of this study was to establish the phylogenetic relationships of trypanosomes present in blood samples of Bolivian Carollia bats. Eighteen cloned stocks were isolated from 115 bats belonging to Carollia perspicillata (Phyllostomidae) from three ...
Lineth García, Sylvia Ortiz, Gonzalo Osorio, Mary Cruz Torrico, Faustino Torrico, Aldo Solari   +5 more
doaj   +1 more source