Inactive trans-sialidase expression in iTS-null Trypanosoma cruzi generates virulent trypomastigotes [PDF]
, 2017 Disclosing virulence factors from pathogens is required to better understand the pathogenic mechanisms involved in their interaction with the host. In the case of Trypanosoma cruzi several molecules are associated with virulence.
Bertelli, Adriano +6 more
core +1 more source
Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart of Trypanosoma cruzi-Infected Mice [PDF]
, 2017 Trypanosoma cruzi infection induces an intense inflammatory response in diverse host tissues. The immune response and the microvascular abnormalities associated with infection are crucial aspects in the generation of heart damage in Chagas disease.
Carta, Davide +9 more
core +2 more sources
Anti-Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone structure [PDF]
, 2018 Chagas disease is a neglected tropical affection caused by the protozoan parasite Trypanosoma cruzi. There is no current effective treatment since the only two available drugs have a limited efficacy and produce side effects.
Benaim, Gustavo +4 more
core +1 more source
Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]
, 2019 Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad +5 more
core +1 more source
Revista da Sociedade Brasileira de Medicina Tropical, 2010 INTRODUÇÃO: A pesquisa da fonte alimentar dos triatomíneos auxilia no conhecimento sobre a biologia destes insetos, inclusive para inferir-se a importância dos mesmos como transmissores do Trypanosoma cruzi ao homem.
Marcos Marreiro Villela +3 more
doaj +1 more source
Astrocyte Apoptosis and HIV Replication Are Modulated in Host Cells Coinfected with Trypanosoma cruzi [PDF]
, 2017 The protozoan Trypanosoma cruzi is the etiological agent of Chagas disease. In immunosuppressed individuals, as it occurs in the coinfection with human immunodeficiency virus (HIV), the central nervous system may be affected. In this regard, reactivation
Burgos, Juan Miguel +5 more
core +1 more source
Structure, kinetic characterization and subcellular localization of the two ribulose 5-phosphate epimerase isoenzymes from Trypanosoma cruzi [PDF]
, 2017 The enzyme of the pentose phosphate pathway (PPP) ribulose-5-phosphate-epimerase (RPE) is encoded by two genes present in the genome of Trypanosoma cruzi CL Brener clone: TcRPE1 and TcRPE2. Despite high sequence similarity at the amino acid residue level,
Cazzulo, Juan Jose +4 more
core +6 more sources
Trypanosoma cruzi prevalence and clinical forms in blood donor candidates in Brazil
Revista de Saúde Pública, 2003 The prevalence and clinical forms of Trypanosoma cruzi were evaluated among blood donor candidates attended at a general hospital in Rio de Janeiro, Brazil, from January 1997 to April 1999.
Silveira H J +3 more
doaj +3 more sources
Histopathologic identification of Trypanosoma cruzi (Chagas') encephalitis in an AIDS patient
Human Pathology: Case Reports, 2017 Trypanosoma cruzi (Chagas') encephalitis is an uncommon manifestation of T. cruzi infection, typically seen in immunocompromised patients. Encephalitis results from the reactivation of chronic infection predominately in individuals from endemic areas ...
Dimath Alyemni +8 more
doaj +1 more source
Host-Parasite Interactions in Chagas Disease: Genetically Unidentical Isolates of a Single Trypanosoma cruzi Strain Identified In Vitro via LSSP-PCR. [PDF]
PLoS ONE, 2015 The present study aims at establishing whether the diversity in pathogenesis within a genetically diverse host population infected with a single polyclonal strain of Trypanosoma cruzi is due to selection of specific subpopulations within the strain.
Nívia Carolina Nogueira-Paiva +10 more
doaj +1 more source