Results 41 to 50 of about 32,421 (180)

Detection of Trypanosoma cruzi in a Reactive Blood Bank Sample in Sonora, Mexico

Tropical Medicine and Infectious Disease
Chagas disease is a neglected disease caused by the parasite Trypanosoma cruzi, a public health problem in both endemic and non-endemic countries. In Mexico, the southern region is considered endemic, and cases are frequently reported; however, in the ...
Idalia Paredes-Sotelo, Mónica Reséndiz-Sandoval, Adriana Garibay-Escobar, Edgar Alfonso Paredes-González, Aracely Angulo-Molina, Angel Ramos-Ligonio, Eric Dumonteil, Claudia Herrera, Olivia Valenzuela   +8 more
doaj   +1 more source

Prevalence of antibodies against Trypanosoma cruzi in pregnant women in endemic areas of the department of Boyacá, Colombia

Iatreia, 2017
Objective: To determine the prevalence of antibodies against Trypanosoma cruzi in pregnant women in endemic areas of Boyacá, Colombia, in 2012 and 2013.
Suescún-Carrero, Sandra Helena, García-Artunduaga, Claudia, Valdivieso-Bohórquez, Silvia   +2 more
doaj   +1 more source

Budget impact of implementing universal Plasmodium NAT screening in the blood transfusion system in the US

Transfusion, EarlyView.
Abstract Background Blood donor deferral for malaria risk relies exclusively on responses to self‐reported questionnaires. This study evaluated the economic impact of introducing Plasmodium nucleic acid testing (NAT) as a universal screening strategy in the United States.
Cristina Coll‐Ortega, Elisabet Viayna, Jiani Zhou, Susan L. Stramer   +3 more
wiley   +1 more source

Virtual Screening Based on QSAR and Molecular Docking of Possible Inhibitors Targeting Chagas CYP51

Journal of Chemistry, 2021
Chagas is a neglected tropical disease caused by the parasite Trypanosoma cruzi with no effective treatment in all its forms. There is a need to find more effective therapeutic alternatives with reduced toxicity.
J. Cotuá, H. LLinás, S. Cotes
doaj   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 9, Page 913-932, November 2026.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Old disease, new twist

Journal of Hospital Medicine, Volume 21, Issue 11, Page 1305-1309, November 2026.
Abstract An 81‐year‐old man with a history of high‐grade urothelial carcinoma of the bladder and ureter on treatment with atezolizumab and tiragolumab presented to the emergency department with 5 months of malaise, generalized weakness, and fatigue and 2 weeks of subjective fevers. One month prior to presentation, he received an empiric 9‐day course of
Hadi Roudsari, Gurpreet Dhaliwal, Anand D. Jagannath, Alan H. Baik, Sam Brondfield   +4 more
wiley   +1 more source

Prevalência de triatomíneos (Hemíptera: Reduviidae: Triatominae) infectados por Trypanosoma cruzi: sazonalidade e distribuição na região Ciénega do Estado de Jalisco, México Prevalence of triatomines (Hemíptera: Reduviidae: Triatominae) infected by Trypanosoma cruzi: seasonality and distribution in the Ciénega region of the State of Jalisco, Mexico

Revista da Sociedade Brasileira de Medicina Tropical, 2008
As características físico-geográficas da região Ciénega, Jalisco, México a tornam propícia para transmissão do Trypanosoma cruzi, causador da doença de Chagas.
César Gómez-Hernández, Karine Rezende-Oliveira, Agustín Cortés Zárate, Esperanza Cortés Zárate, Francisco Trujillo-Contreras, Luis Eduardo Ramirez   +5 more
doaj   +1 more source

Assessment of the Binding Affinity of Covalent Inhibitors of Cruzain and Cathepsin L Using Relative Binding Free Energy

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Six nitrile‐based covalent inhibitors are evaluated against cruzain and hCatL. Thermodynamic integration accurately predicts relative binding affinities by modeling the covalent adduct state. We identify a structural difference in the S2 subsite that governs ligand selectivity, offering valuable insights for drug discovery.
Yan Carvalho Magno, Luiz Fernando Barbosa, Maycon Vinicius Damasceno de Oliveira, Jerônimo Lameira, Carlos A. Montanari   +4 more
wiley   +1 more source

Molecular characterization of Trypanosoma cruzi Mexican strains and their behavior in the mouse experimental model

Revista da Sociedade Brasileira de Medicina Tropical, 2011
INTRODUCTION: For a long time, the importance of Chagas disease in Mexico, where many regarded it as an exotic malady, was questioned. Considering the great genetic diversity among isolates of Trypanosoma cruzi, the importance of this biological ...
César Gómez-Hernández, Karine Rezende-Oliveira, Gabriel Antônio Nogueira Nascentes, Lara Rocha Batista, Henrique Borges Kappel, José Alejandro Martinez-Ibarra, Francisco Trujillo Contreras, Eliane Lages-Silva, Luis Eduardo Ramírez   +8 more
doaj   +1 more source

Synthesis, Antiparasitic Activity, and ADME Profile of Morpholinephenylbenzamides: A Pharmacological Study Against Chagas Disease and Visceral Leishmaniasis

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Danilo Nascimento Farago, Daniela de Melo Resende, Mariza Gabriela Faleiro de Moura Lodi Cruz, Rafaela Marçal Sousa, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Felipe da Silva Mendonça de Melo, Douglas Davison da Silva Oliveira, Paula Derksen Macruz, Alexandra Maria dos Santos Carvalho, Eduardo Jorge Pilau, Izabela Marques Dourado Bastos, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +15 more
wiley   +1 more source