Results 51 to 60 of about 83,341 (233)

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

North American import? Charting the origins of an enigmatic Trypanosoma cruzi domestic genotype. [PDF]

, 2012
BACKGROUND: Trypanosoma cruzi, the agent of Chagas disease, is currently recognized as a complex of six lineages or Discrete Typing Units (DTU): TcI-TcVI. Recent studies have identified a divergent group within TcI - TcI(DOM). TcI(DOM).
Perrin, P.B., Martínez-Ibarra Alejandro J, Zumaya-Estrada, Federico A, Lopez-Ordonez, T., Segovia Maikel, Hernan V Carrasco, Pamela M Pennington, Louisa A Messenger, Miles Michael A, Carrasco, Hernan V, Martínez-Ibarra, Alejandro J, Segovia, Maikel, Michael D Lewis, Messenger, Louisa A, Everhart, R.S., Miles, M.A., Llewellyn, Martin S, Martin S Llewellyn, Miles, Michael A, Federico A Zumaya-Estrada, Lewis, Michael D, Lewis Michael D, Cordon-Rosales, Celia, Lopez-Ordonez Teresa, Jimenez-Maldonado, M., Cordon-Rosales Celia, Teresa Lopez-Ordonez, Pennington Pamela M, Pennington, Pamela M, Cordon-Rosales, C., Llewellyn, M.S., Llewellyn Martin S, Trapp, S.K., Lewis, M.D., Martinez-Ibarra, A.J., Pennington, P.M., Lopez-Ordonez, Teresa, Arango-Lasprilla, J.C., Michael A Miles, Flores-Lopez, Carlos A, Flores-Lopez Carlos A, Messenger Louisa A, Messenger, L.A., Flores-Lopez, C.A., Carrasco Hernan V, Carlos A Flores-Lopez, Leibach, G.G., Carrasco, H.V., Celia Cordon-Rosales, Alejandro J Martínez-Ibarra, Zumaya-Estrada, F.A., Maikel Segovia, Segovia, M., Cabrera, T.V., Zumaya-Estrada Federico A   +54 more
core   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

High prevalence of Trypanosoma cruzi infection in shelter dogs from southern Louisiana, USA

Parasites & Vectors, 2019
Background Chagas disease is a zoonotic disease caused by the protozoan parasite Trypanosoma cruzi. The role of dogs as sentinels has been proposed in multiple regions, as they are a domestic reservoir for T. cruzi.
Ardem Elmayan, Weihong Tu, Brandy Duhon, Preston Marx, Wendy Wolfson, Gary Balsamo, Claudia Herrera, Eric Dumonteil   +7 more
doaj   +1 more source

Calcitonin‐like diuretic hormone influences reproduction in adult female Rhodnius prolixus

Insect Science, EarlyView.
Highlights • CT/DH‐like immunoreactivity is present in female reproductive tissues • CT/DH receptor transcripts are expressed in the fat body and ovaries • RNAi knockdown of CT/DH receptors reduces egg number and hatching rate • Rhopr‐CT/DH increases RhoprVg1 and RhoprVgR expression in ovaries in vitro • Rhopr‐CT/DH stimulates oviduct contractions in a
Areej N. Al‐Dailami, Ian Orchard, Angela B. Lange   +2 more
wiley   +1 more source

Análise proteômica de formas tripomastigotas diferenciadas in vitro do Trypanosoma rangeli e caracterização de antígenos diferenciais ao Trypanosoma cruzi [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2012A distribuição simpátrica e o compartilhamento de hospedeiros e antígenos entre o Trypanosoma rangeli
Wagner, Glauber
core  

Candidate targets for Multilocus Sequence Typing of Trypanosoma cruzi: validation using parasite stocks from the Chaco Region and a set of reference strains.

, 2012
A Multilocus Sequence Typing (MLST) scheme was designed and applied to a set of 20 Trypanosoma cruzi stocks belonging to three main discrete typing units (T. cruzi I, V and VI) from a geographically restricted Chagas disease endemic area in Argentina, 12
Rumi, M. M. M., D'Amato, A. M. A., Barnabé, C., Yeo, Matthew, Lauthier, J.J., Basombrio, M. A., Tomasini, N., Ragone, P.G., Lewis, M. D., Lauthier, Juan J, Miles, M. A., Miles, M.A., Tibayrenc, M., Ragone, P. G., Ragone, Paula G, Yeo, M., Barnabé, Christian, Basombrío, Miguel A, Tibayrenc, Michel, Llewellyn, M. S., Diosque, Patricio, Tomasini, Nicolás, Llewellyn, Martin S, D'Amato, Anahí M Alberti, Miles, Michael A, Lewis, M.D., D’Amato, A.M. A., Rumi, María M Monje, Diosque, P., Lewis, Michael D, Rumi, M.M.M., Lauthier, J. J., Basombrío, M.A., Llewellyn, M.S.   +33 more
core   +1 more source

Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients. [PDF]

, 2015
BACKGROUND: Chagas disease results from infection with the diploid protozoan parasite Trypanosoma cruzi. T. cruzi is highly genetically diverse, and multiclonal infections in individual hosts are common, but little studied.
Torrico, Faustino, Tavares, Suelene BN, Torrico, F., Louisa A Messenger, Sauer, S., Céline Baulard (718392), Delepine, M., Baulard, Céline, Bachar Cheaib, Deleuze, Jean-Francois, Cheaib, Bachar, Garcia, Lineth, Marc Delepine, Jean-Francois Deleuze, Nicolas Derome (2201653), Luquetti, A.O., Martin S. Llewellyn (155605), Faustino Torrico (102187), Miles, M.A., Messenger, Louisa A, Derome, Nicolas, Louisa A. Messenger (172069), Delepine, Marc, Michael A. Miles (43726), Llewellyn, Martin S, Sauer, Sascha, Martin S Llewellyn, Tavares, S.B.N., Miles, Michael A, Sascha Sauer (271148), Deleuze, J.F., Llewellyn, M.S., Messenger, L.A., Sascha Sauer, Suelene B. N. Tavares (505260), Deleuze, J.-F., Michael A Miles, Alejandro O. Luquetti (505259), Jean-Francois Deleuze (718393), Alejandro O Luquetti, Lineth Garcia, Luquetti, Alejandro O, Cheaib, B., Garcia, L., Nicolas Derome, Lineth Garcia (102146), Céline Baulard, Derome, N., Faustino Torrico, Marc Delepine (184928), Baulard, C., Suelene B N Tavares, Bachar Cheaib (718391)   +52 more
core   +1 more source

Identification of seropositive cases of Chagas disease in pregnant women in a non-endemic risk area of the state of Mexico: The importance of screening prenatal

Parasite Epidemiology and Control
Objective: Our study aimed to identify seropositive cases of Trypanosoma cruzi in pregnant women from the northeastern region of the State of Mexico and underscore the importance of screening for this disease in prenatal care.
Saúl González-Guzmán, José A. Crescencio-Trujillo, Carla I. Arroyo-Anduiza, María Guadalupe Córdova-Espinoza, Roberto Alvarado-Velázquez, Vladimir Paredes-Cervantes   +5 more
doaj   +1 more source

Putting Rodents at the Center of One Health Programs: A Narrative Synthesis

Integrative Zoology, EarlyView.
Rodents link human, animal, and environmental health across diverse ecosystems. Rodent diversity underpins both zoonotic disease risk and ecosystem function. Environmental change reshapes rodent communities and spillover dynamics. Rodents act as reservoirs, amplifiers, and sentinels of emerging pathogens.
Steven R. Belmain
wiley   +1 more source