Results 71 to 80 of about 83,341 (233)

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Molecular characterization of Trypanosoma cruzi Mexican strains and their behavior in the mouse experimental model

Revista da Sociedade Brasileira de Medicina Tropical, 2011
INTRODUCTION: For a long time, the importance of Chagas disease in Mexico, where many regarded it as an exotic malady, was questioned. Considering the great genetic diversity among isolates of Trypanosoma cruzi, the importance of this biological ...
César Gómez-Hernández, Karine Rezende-Oliveira, Gabriel Antônio Nogueira Nascentes, Lara Rocha Batista, Henrique Borges Kappel, José Alejandro Martinez-Ibarra, Francisco Trujillo Contreras, Eliane Lages-Silva, Luis Eduardo Ramírez   +8 more
doaj   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Estudo da interação celular parasito-hospedeiro a partir da expressão heteróloga de trans-sialidase de Trypanosoma cruzi por Trypanosoma rangeli em ensaios in vitro e in vivo [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Biotecnologia e Biociências, Florianópolis, 2013As trans-sialidades de Trypanosoma cruzi (TcTS) são capazes de clivar resíduos de
Granucci, Ninna
core  

Busca retrospectiva da transmissão maternal da infecção chagásica em pacientes na fase crônica A retrospective search for maternal transmission of Chagas infection from patients in the chronic phase

Revista da Sociedade Brasileira de Medicina Tropical, 2004
Avaliamos a transmissão maternal do Trypanosoma cruzi em 278 filhos de 145 mães com a doença crônica causada por esse protozoário, nascidos após o estabelecimento do diagnóstico materno.
Anis Rassi, Vicente Amato Neto, Gustavo Gabriel Rassi, Valdir Sabbaga Amato, Anis Rassi Júnior, Alejandro O. Luquetti, Sérgio Gabriel Rassi   +6 more
doaj   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Molecular epidemiologic source tracking of orally transmitted Chagas disease, Venezuela. [PDF]

, 2013
Oral outbreaks of Chagas disease are increasingly reported in Latin America. The transitory presence of Trypanosoma cruzi parasites within contaminated foods, and the rapid consumption of those foods, precludes precise identification of outbreak origin ...
Hernán J. Carrasco, Juan C. Londoño, Cinda Martínez, Michael A. Miles, Rafael Bonfante-Cabarcas, Carrasco, Hernán J, Bonfante-Cabarcas, Rafael, de Noya, Belkisyolé A, Louisa A. Messenger, Londoño, Juan C, Raul Espinosa, Martínez, Clara E, Martínez, Cinda, Anaibeth Nessi, Nessi, Anaibeth, Mijares Alfredo, Messenger, Louisa A, Alfredo, Mijares, Martin S. Llewellyn, Michael D. Lewis, Llewellyn, Martin S, Segovia, Maikell, Miles, Michael A, Espinosa, Raul, Lewis, Michael D, Clara E. Martínez, Maikell Segovia, Belkisyolé A. de Noya   +27 more
core   +1 more source

Synthesis and Evaluation of Peptoid‐Based Compound Libraries as Inhibitors of Parasite Metallo‐Aminopeptidases

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Evaluation of two libraries of peptoid‐based compounds for inhibitory activity against PfA‐M1 from Plasmodium falciparum, TcLAP from Trypanosoma cruzi, and LmLAP from Leishmania major reveals the crucial role of hydrophobic interactions in the inhibition process of these parasite metallo‐aminopeptidases.
Mirta Elisa Aguado, Gerardo M. Ojeda‐Carralero, Mario Antonio Rodríguez, Isabella Rúa, Heisy Guerra, Edoardo Bailo Hernández, Guglielmo Coppola, Susana Alberti, Ariatne Rodríguez, Maikel Izquierdo, Christian Betzel, Filippo Pettazzi, Julieta Coro‐Bermello, Erik V. Van der Eycken, Bernhard Westermann, Jorge González‐Bacerio, Daniel G. Rivera   +16 more
wiley   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

Novo encontro do Trypanosoma (Megatrypanum) freitasi, parasita do gambá A new finding of Trypanosoma (Megatrypanum) freitasi, parasite of the opossum

Revista de Saúde Pública, 1976
Relata-se um novo encontro do Trypanosoma (Megatrypanum) freitasi, raro tripanosomatídeo encontrado no sangue de marsupiais, do gênero Didelphis.
Eduardo Olavo da Rocha e Silva, Dino Baptista Germano Pattoli, José de Campos Camargo   +2 more
doaj   +1 more source