Different Transcriptomic Responses After Moderate and Severe Heat Shock in Trypanosoma cruzi Epimastigotes. [PDF]
ABSTRACT Trypanosoma cruzi undergoes heat stress during its life cycle. In this study, we performed a transcriptomic analysis of the heat shock response in epimastigotes from different T. cruzi strains. In both clone CL Brener and the Y strain, very few to no statistically significant variations were observed in the transcriptome at 37°C, whereas ...
Bottaro T +3 more
europepmc +2 more sources
Acute Phase Proteins in Dogs with Natural Infection by Trypanosoma cruzi
Acute phase proteins have been used as tools for the diagnosis, monitoring, and prognosis of several diseases in domestic animals. However, the dynamics of these proteins in infection by Trypanosoma cruzi, the causative agent of Chagas disease in dogs ...
Pilar Rivadeneira-Barreiro +8 more
doaj +1 more source
Chagas disease, caused by the infection with the protozoan parasite Trypanosoma cruzi, is clinically manifested in approximately one-third of infected people by inflammatory heart disease (cardiomyopathy) and, to a minor degree, gastrointestinal tract ...
Santiago J. Martinez +5 more
doaj +1 more source
Flagellar pocket receptors as entry point for protein-based drugs against kinetoplastid parasites [PDF]
Aim: Kinetoplastids are flagellated protozoa encompassing multiple parasitic species responsible for severe neglected diseases. Although treatments exist, therapeutic failure and toxic side effects underscore the need for innovative drug development ...
Lucila Attala +2 more
doaj +1 more source
Recent, independent and anthropogenic origins of Trypanosoma cruzi hybrids. [PDF]
The single celled eukaryote Trypanosoma cruzi, a parasite transmitted by numerous species of triatomine bug in the Americas, causes Chagas disease in humans. T.
Michael A. Miles +28 more
core +2 more sources
Comparative genomic analysis of human infective Trypanosoma cruzi lineages with the bat-restricted subspecies T. cruzi marinkellei. [PDF]
BACKGROUND: Trypanosoma cruzi marinkellei is a bat-associated parasite of the subgenus Schizotrypanum and it is regarded as a T. cruzi subspecies. Here we report a draft genome sequence of T. c. marinkellei and comparison with T. c. cruzi.
Andersson, B. +55 more
core +1 more source
Phylogenetic analysis of Bolivian bat trypanosomes of the subgenus schizotrypanum based on cytochrome B sequence and minicircle analyses. [PDF]
The aim of this study was to establish the phylogenetic relationships of trypanosomes present in blood samples of Bolivian Carollia bats. Eighteen cloned stocks were isolated from 115 bats belonging to Carollia perspicillata (Phyllostomidae) from three ...
Lineth García +5 more
doaj +1 more source
María Teresa Palá, Luis E. Gualdrón
doaj +3 more sources
Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi. [PDF]
BACKGROUND: Multilocus sequence typing (MLST) is a powerful and highly discriminatory method for analysing pathogen population structure and epidemiology. Trypanosoma cruzi, the protozoan agent of American trypanosomiasis (Chagas disease), has remarkable
Michael A. Miles +61 more
core +2 more sources
Trypanosoma Species in Small Nonflying Mammals in an Area With a Single Previous Chagas Disease Case
Trypanosomatids are hemoflagellate parasites that even though they have been increasingly studied, many aspects of their biology and taxonomy remain unknown. The aim of this study was to investigate the Trypanosoma sp.
Maria Augusta Dario +5 more
doaj +1 more source

