Results 1 to 10 of about 284,016 (133)

SARS-CoV-2 viral dynamics in a placebo-controlled phase 2 study of patients infected with the SARS-CoV-2 Omicron variant and treated with pomotrelvir

Microbiology Spectrum
Current guidelines recommend that individuals with moderate COVID-19 disease isolate for 5 days after the first appearance of symptoms or a positive SARS-CoV-2 test.
Katyna Borroto-Esoda, David Wilfret, Xiao Tong, Andrew Plummer, Brian Kearney, Ann D. Kwong   +5 more
doaj   +1 more source

Transcriptomic and metabolomic analysis unveils a negative effect of glutathione metabolism on laccase activity in Cerrena unicolor 87613

Microbiology Spectrum
The white rot fungus Cerrena unicolor 87613 has been previously shown to be a promising resource in laccase production, an enzyme with significant biotechnological applications. Conventional methods face technical challenges in improving laccase activity.
Long-Bin Zhang, Ting-Ting Qiu, Xiu-Gen Qiu, Wu-Wei-Jie Yang, Xiu-Yun Ye, Chun Meng   +5 more
doaj   +1 more source

Genome-wide bioinformatics analysis of human protease capacity for proteolytic cleavage of the SARS-CoV-2 spike glycoprotein

Microbiology Spectrum
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) primarily enters the cell by binding the virus’s spike (S) glycoprotein to the angiotensin-converting enzyme 2 receptor on the cell surface, followed by proteolytic cleavage by host proteases ...
Evgenii V. Matveev, Gennady V. Ponomarev, Marat D. Kazanov   +2 more
doaj   +1 more source

Molecular characteristics, fitness, and virulence of high-risk and non-high-risk clones of carbapenemase-producing Klebsiella pneumoniae

Microbiology Spectrum
Extensively drug-resistant (XDR) Klebsiella pneumoniae inflict a notable burden on healthcare worldwide. Of specific concern are strains producing carbapenem-hydrolyzing enzymes, as the therapeutic options for these strains are still very limited ...
Anni-Maria Örmälä-Tiznado, Lisa Allander, Makaoui Maatallah, Muhammad Humaun Kabir, Sylvain Brisse, Linus Sandegren, Sheetal Patpatia, Maarten Coorens, Christian G. Giske   +8 more
doaj   +1 more source

Genome-Wide Association Analysis for Salt-Induced Phenotypic and Physiologic Responses in Rice at Seedling and Reproductive Stages. [PDF]

Front Plant Sci, 2022
Chen G, Hu K, Zhao J, Guo F, Shan W, Jiang Q, Zhang J, Guo Z, Feng Z, Chen Z, Wu X, Zhang S, Zuo S.   +12 more
europepmc   +1 more source

SMR peptide antagonizes Staphylococcus aureus biofilm formation

Microbiology Spectrum
The emergence and international dissemination of multi-drug resistant Staphylococcus aureus (S. aureus) strains challenge current antibiotic-based therapies, representing an urgent threat to public health worldwide. In the U.S. alone, S.
Ming-Bo Huang, Dara Brena, Jennifer Y. Wu, Martin Shelton, Vincent C. Bond   +4 more
doaj   +1 more source

The Carbon Emission Characteristics and Reduction Potential in Developing Areas: Case Study from Anhui Province, China. [PDF]

Int J Environ Res Public Health, 2022
Zhang K, Jiang L, Jin Y, Liu W.
europepmc   +1 more source

A shift between mineral and nonmineral sources of iron and sulfur causes proteome-wide changes in Methanosarcina barkeri

Microbiology Spectrum
Iron (Fe) and sulfur (S) are required elements for life, and changes in their availability can limit the ecological distribution and function of microorganisms. In anoxic environments, soluble Fe typically exists as ferrous iron [Fe(II)] and S as sulfide
Hunter Fausset, Rachel L. Spietz, Savannah Cox, Gwendolyn Cooper, Scott Spurzem, Monika Tokmina-Lukaszewska, Jennifer DuBois, Joan B. Broderick, Eric M. Shepard, Eric S. Boyd, Brian Bothner   +10 more
doaj   +1 more source

Nosocomial surveillance of multidrug-resistant Acinetobacter baumannii: a genomic epidemiological study

Microbiology Spectrum
Acinetobacter baumannii is a major opportunistic pathogen causing hospital-acquired infections, and it is imperative to comprehend its evolutionary and epidemiological dynamics in hospitals to prevent and control nosocomial transmission. Here, we present
Zhimei Duan, Xuming Li, Song Li, Hui Zhou, Long Hu, Han Xia, Lixin Xie, Fei Xie   +7 more
doaj   +1 more source

Cefiderocol: early clinical experience for multi-drug resistant gram-negative infections

Microbiology Spectrum
Multi-drug resistant gram-negative bacteria present a significant global health threat. Cefiderocol (CFDC), a siderophore cephalosporin, has shown potential in combating this threat, but with the currently available data, its role in therapy remains ...
Amer El Ghali, Ashlan J. Kunz Coyne, Kristen Lucas, Molly Tieman, Xhilda Xhemali, Suet-ping Lau, Gabriela Iturralde, Andrew Purdy, Dana J. Holger, Esther Garcia, Michael P. Veve, Michael J. Rybak   +11 more
doaj   +1 more source