Results 31 to 40 of about 209,429 (67)

DNA Damage Response Regulation Alleviates Neuroinflammation in a Mouse Model of α-Synucleinopathy

Biomolecules
Parkinson’s disease (PD) is a progressive neurodegenerative disorder marked by the degeneration of dopaminergic neurons in the substantia nigra, leading to decreased dopamine levels in the striatum and causing a range of motor and non-motor impairments ...
Sazzad Khan, Himanshi Singh, Jianfeng Xiao, Mohammad Moshahid Khan   +3 more
doaj   +1 more source

Exploring the Antimicrobial and Immunomodulatory Potential of Gecko-Derived Cathelicidin Gj-CATH5

Biomolecules
Regulating the innate immune response against infections, particularly drug-resistant bacteria, is a key focus in anti-infection therapy. Cathelicidins, found in vertebrates, are crucial for pathogen resistance.
Shasha Cai, Ningyang Gao, Junhan Wang, Jing Li   +3 more
doaj   +1 more source

New Benzimidazole 3′-Deoxynucleosides: Synthesis and Antiherpes Virus Properties

Biomolecules
A series of new 3′-deoxyribosides of substituted benzimidazoles was obtained by the chemo-enzymatic method using genetically engineered E. coli purine nucleoside phosphorylase (PNP).
Aleksandra O. Arnautova, Irina A. Aleksakhina, Ekaterina A. Zorina, Maria Ya. Berzina, Ilya V. Fateev, Barbara Z. Eletskaya, Konstantin V. Antonov, Olga S. Smirnova, Alexander S. Paramonov, Alexey L. Kayushin, Valeria L. Andronova, Georgii A. Galegov, Maria A. Kostromina, Evgeny A. Zayats, Inna L. Karpenko, Svetlana K. Kotovskaya, Valery N. Charushin, Roman S. Esipov, Anatoly I. Miroshnikov, Irina D. Konstantinova   +19 more
doaj   +1 more source

Genome-Wide Association Analysis for Salt-Induced Phenotypic and Physiologic Responses in Rice at Seedling and Reproductive Stages. [PDF]

Front Plant Sci, 2022
Chen G, Hu K, Zhao J, Guo F, Shan W, Jiang Q, Zhang J, Guo Z, Feng Z, Chen Z, Wu X, Zhang S, Zuo S.   +12 more
europepmc   +1 more source

The Role of Macrophage-Derived Netrin-1 in Inflammatory Diseases

Biomolecules
Macrophages are multifunctional immune cells distributed throughout the whole body, and they have functions in antigen presentation, phagocytosis, killing, and immune regulation.
Yi Wu, Zhiying Liu, Peiqi Xu, Kai Yin, Shengjun Wang   +4 more
doaj   +1 more source

The Carbon Emission Characteristics and Reduction Potential in Developing Areas: Case Study from Anhui Province, China. [PDF]

Int J Environ Res Public Health, 2022
Zhang K, Jiang L, Jin Y, Liu W.
europepmc   +1 more source

Advancing Semiochemical Tools for Mountain Pine Beetle Management: Dendroctonus ponderosae Responses to Saprophytic Fungal Volatiles

Metabolites
Background/Objectives: Within their host trees, mountain pine beetles (MPBs, Dendroctonus ponderosae) interact with many fungal species, each releasing a unique profile of volatile organic compounds (VOCs). The FVOCs released by the two primary symbionts
Leah Crandall, Rashaduz Zaman, Guncha Ishangulyyeva, Nadir Erbilgin   +3 more
doaj   +1 more source

Exploratory Metabolomic and Lipidomic Profiling in a Manganese-Exposed Parkinsonism-Affected Population in Northern Italy

Metabolites
Background/Objectives: Chronic manganese (Mn) exposure is a recognized environmental contributor to Parkinsonian syndromes, including Mn-induced Parkinsonism (MnIP).
Freeman Lewis, Daniel Shoieb, Somaiyeh Azmoun, Elena Colicino, Yan Jin, Jinhua Chi, Hari Krishnamurthy, Donatella Placidi, Alessandro Padovani, Andrea Pilotto, Fulvio Pepe, Marinella Tula, Patrizia Crippa, Xuexia Wang, Haiwei Gu, Roberto Lucchini   +15 more
doaj   +1 more source

Cross-Sectional and Longitudinal Assessment of Sociodemographic and Lifestyle Determinants of Metabolic Syndrome and Hypertriglyceridemic Waist Phenotypes in 139,634 Spanish Workers

Metabolites
Objective: The objective of this study was to analyze the prevalence and key sociodemographic and lifestyle determinants of metabolic syndrome (MetS) and the hypertriglyceridemic waist (HTGW) phenotype in a large occupational cohort.
Joan Obrador de Hevia, Ángel Arturo López-González, José Ignacio Ramírez-Manent, Carla Busquets-Cortés, Pedro Juan Tárraga López, Pere Riutord-Sbert   +5 more
doaj   +1 more source

Chemistry and bioactivities of natural steroidal alkaloids. [PDF]

Nat Prod Bioprospect, 2022
Xiang ML, Hu BY, Qi ZH, Wang XN, Xie TZ, Wang ZJ, Ma DY, Zeng Q, Luo XD.   +8 more
europepmc   +1 more source