Results 11 to 20 of about 2,601,171 (128)

34^th European Congress of Pathology - Abstracts. [PDF]

Virchows Arch, 2022
Background & objectives: Cancer cells can avoid immune destruction through the inhibitory ligand PD-L1. PD-1 is a surface cell receptor, part of the immunoglobulin family.
Filipovski, Vanja, Kubelka-Sabit, Katerina, Jasar, Dzengis, Kondeva, Marija   +3 more
europepmc   +2 more sources

Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp. [PDF]

, 2013
Agents capable of inducing phase II enzymes such as quinone reductase 1 (QR1) are known to have the potential of mediating cancer chemopreventive activity.
John M. Pezzuto (217117), Bernard D. Santarsiero (1344840), Brian T. Murphy (1621375), Laura Marler (2381374), Skylar Carlson (1621381), Sang-Jip Nam (334832)   +5 more
core   +4 more sources

Cycle redox quinone/quinone réductase 2 et conséquences sur la production d'espèces oxygénées réactives dans le contexte cellulaire [PDF]

, 2015
Quinone reductase 2 or QR2 is an enzyme that, like its counterpart QR1, plays a role in detoxification of the highly reactives quinones by reducing them into hydroquinones.
Cassagnes, Laure-Estelle
core   +2 more sources

Evaluation of PD-L1 expression in tumor tissue [PDF]

, 2021
The interaction between the immune system and cancer cells is complex. Cancer cells can avoid immune destruction by suppressing the immune system. Tumors can create an immunosuppressive microenvoirment and therefore cytotoxic T lymphocytes (CTL) can't ...
Jovevska, Svetlana, Kondeva, Marija
core   +1 more source

Knockdown of circ-PRKCH alleviates IL-1β-treated chondrocyte cell phenotypic changes through modulating miR-502-5p/ADAMTS5 axis

, 2022
Osteoarthritis (OA) is a common joint disease characterized by progressive cartilage degradation. Circular RNAs (circRNAs) are involved in the initiation and development of OA.
Tinghan Yan (12321197), Limin Zhang (297459), Peng Zhou (116747), Jinlong Li (388896), Zhongxing Liu (12321194), Jian Cao (16485), Sidi Zhang (3281802)   +6 more
core   +1 more source

Evaluation of Beauvericin’s activity and mode of action against all life stages of L. tropica for cutaneous Leishmaniasis therapy

Frontiers in Cellular and Infection Microbiology
BackgroundLeishmaniasis, particularly its cutaneous form caused by Leishmania tropica, remains a significant global health concern due to the limitations of current treatments, including drug resistance, toxicity, and inconsistent efficacy.
Lynn Al Samra, Mohamad El Nahas, Ilham Mneimneh, Aia Sinno, Sima Tokajian, Kelven Rahy, Sergio Thoumi, Lazo Ali, Wael Yammine, Charbel Al Khoury   +9 more
doaj   +1 more source

Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen

, 2000
An extensive body of evidence supports the conclusion that by catalyzing obligatory two-electron reductions of quinones to hydroquinones, NAD(P)H:quinone reductase (QR1) protects cells against the deleterious effects of redox cycling of quinones, their ...
Albena T Dinkova-Kostova, Talalay, Paul, Paul Talalay, Dinkova-Kostova, Albena T.; id_orcid   +3 more
core   +1 more source

A single-electron reducing quinone oxidoreductase is necessary to induce haustorium development in the root parasitic plant Triphysaria

, 2010
Parasitic plants in the Orobanchaceae develop haustoria in response to contact with host roots or chemical haustoria-inducing factors. Experiments in this manuscript test the hypothesis that quinolic-inducing factors activate haustorium development via a
Tomilov, A, Tomilova, N B, Jamison-McClung, D, Inoue, K, Bandaranayake, P C G, Filappova, T, Yoder, J I, Ngo, Q   +7 more
core   +1 more source

Participant 502 Community Conversations Transcribed interview

, 2021
In this transcribed interview, Participant 502 describes their experience working as a state trooper during the COVID-19 pandemic. The participant talks about extra precautions they had to take to ensure the safety of their family.
Steven
core  

Prevalence of antibiotic resistance genes its association with microbiota in raw milk of northwest Xinjiang

Frontiers in Microbiology
The issue of antibiotic resistance caused by antibiotic resistance genes (ARGs) has become a significant concern in environmental research in recent years, while raw milk is an important link in the food chain and has become one of the carriers and ...
Yan Zhao, Yan Zhao, Yifan Niu, Yifan Niu, Min Zhao, Wanting Huang, Yanan Qin, Yanan Qin   +7 more
doaj   +1 more source