Results 41 to 50 of about 3,959 (186)

Synthesis of New Isoxazolylnaphthoquinones as Potential Trypanocidal and Antibacterial Agents [PDF]

Journal of Chemical Research, 1999
The synthesis of three new isoxazolylnaphthoquinones with an ethyl group on the isoxazole ring is reported.
Gladys E. Granero, María M. de Bertorello, Margarita C. Briñón   +2 more
openaire   +1 more source

Synthesis of indazol‐4,7‐dione derivatives as potential trypanocidal agents

Journal of Heterocyclic Chemistry, 2002
AbstractThe synthesis of new indazol‐4,7‐dione derivatives via 1,3‐dipolar cycloaddition of diazomethane with 2,3‐dimethyl‐1,4‐benzoquinone (2) and 1,4‐naphthoquinone (7) followed by N‐alkylation of the pyrazol nitrogen atom of the corresponding quinones (3) and (8) with methyl chloroacetate is described.
Tapia Apati, Ricardo, Carrasco, Claudia, Ojeda, Scarlet, Salas Sánchez, Cristián Osvaldo, Valderrama Guerrero, Jaime Adolfo, Morello, Antonio, Repetto, Yolanda   +6 more
openaire   +4 more sources

DB75, a Novel Trypanocidal Agent, Disrupts Mitochondrial Function in Saccharomyces cerevisiae [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACT The aromatic diamidines represent a class of compounds with broad-spectrum antimicrobial activity; however, their development is hindered by a lack of understanding of their mechanism of antimicrobial action. DB75 [2,5-bis(4-amidinophenyl)furan] is a trypanocidal aromatic diamidine that was originally developed as a ...
Charlotte A, Lanteri, Bernard L, Trumpower, Richard R, Tidwell, Steven R, Meshnick   +3 more
openaire   +2 more sources

Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated
Alexandra Ibáñez-Escribano, Cristina Fonseca-Berzal, Mónica Martínez-Montiel, Manuel Álvarez-Márquez, María Gómez-Núñez, Manuel Lacueva-Arnedo, Teresa Espinosa-Buitrago, Tania Martín-Pérez, José Antonio Escario, Penélope Merino-Montiel, Sara Montiel-Smith, Alicia Gómez-Barrio, Óscar López, José G. Fernández-Bolaños   +13 more
doaj   +1 more source

Benzopyrazine-Based Small Molecule Inhibitors As Trypanocidal and Leishmanicidal Agents: Green Synthesis, In Vitro, and In Silico Evaluations

Frontiers in Chemistry, 2021
World Health Organization (WHO) identified twenty tropical disease categories as neglected tropical diseases (NTDs)1. Chagas’ disease (also known as American trypanosomiasis) and leishmaniasis are two major classes of NTDs. The total number of mortality,
Jonathan Rock, Daniel Garcia, Omar Espino, Shaila A. Shetu, Manuel J. Chan-Bacab, Rosa Moo-Puc, Navin B. Patel, Gildardo Rivera, Debasish Bandyopadhyay, Debasish Bandyopadhyay   +9 more
doaj   +1 more source

Ferrocene-based nitroheterocyclic sulfonylhydrazones: design, synthesis, characterization and trypanocidal properties

, 2023
International audienceA series of new ferrocenyl nitroheterocyclic sulfonylhydrazones (1a-4a and 1b-2b) were prepared by the reaction between formyl (R = H) or acetyl (R = CH3) nitroheterocyclic precursors [4/5-NO2(C5H2XCOR), where X = O, S)] and ...
Patricia M. Toro, Toro, Patricia M, Henry, Natacha, Natacha Henry, Shane Wilkinson, Rodrigo Arancibia, Gallardo, Miguel, Pascal Roussel, Wilkinson, Shane, Claudio Jiménez, Arancibia, Rodrigo, Miguel Gallardo, Jiménez, Claudio, Roussel, Pascal   +13 more
core   +1 more source

2-(Nitroaryl)-5-Substituted-1,3,4-Thiadiazole Derivatives with Antiprotozoal Activities: In Vitro and In Vivo Study

Molecules, 2022
Nitro-containing compounds are a well-known class of anti-infective agents, especially in the field of anti-parasitic drug discovery. HAT or sleeping sickness is a neglected tropical disease caused by a protozoan parasite, Trypanosoma brucei.
Alireza Mousavi, Parham Foroumadi, Zahra Emamgholipour, Pascal Mäser, Marcel Kaiser, Alireza Foroumadi   +5 more
doaj   +1 more source

A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro

, 2013
Recently, the World Health Organization approved the nifurtimox–eflornithine combination therapy for the treatment of human African trypanosomiasis, renewing interest in nitroheterocycle therapies for this and associated diseases.
Smith, Terry K, Westwood, Nicholas J, Rideau, Emeline, Stewart, Gavin, Zhou, Linna, Westwood, Nicholas James   +5 more
core   +1 more source

Trypanocidal drugs for chronic asymptomatic Trypanosoma cruzi infection. [PDF]

, 2002
BACKGROUND: Prior guidelines stated that trypanocidal therapy should not be used for treating chronic asymptomatic Trypanosoma cruzi infections. However, the recent availability of clinical trials reporting high rates of parasitologic cure in children ...
Luis Angel Villar, Juan Carlos Villar, Shah Ebrahim, Marin-Neto, JA, Yusuf, S, Salim Yusuf, Ebrahim, S, Villar, JC, Jose Antonio Marin-Neto   +8 more
core   +1 more source

Nifurtimox versus benznidazole or placebo for asymptomatic Trypanosoma cruzi infection (Equivalence of Usual Interventions for Trypanosomiasis - EQUITY): study protocol for a randomised controlled trial

Trials, 2019
Background Either benznidazole (BZN) or nifurtimox (NFX) is recommended as equivalent to treat Trypanosoma cruzi infection. Nonetheless, supportive data from randomised trials is limited to individuals treated with BZN in southern cone countries of Latin
Juan Carlos Villar, Víctor Mauricio Herrera, Juan Guillermo Pérez Carreño, Eliana Váquiro Herrera, Yeny Zulay Castellanos Domínguez, Skarlet Marcell Vásquez, Zulma Milena Cucunubá, Nilda Graciela Prado, Yolanda Hernández   +8 more
doaj   +1 more source