Results 41 to 50 of about 7,518 (197)

Repositioning FDA Drugs as Potential Cruzain Inhibitors from Trypanosoma cruzi: Virtual Screening, In Vitro and In Vivo Studies

Molecules, 2017
Chagas disease (CD) is a neglected disease caused by the parasite Trypanosoma cruzi, which affects underdeveloped countries. The current drugs of choice are nifurtimox and benznidazole, but both have severe adverse effects and less effectivity in chronic
Isidro Palos, Edgar E. Lara-Ramirez, Julio Cesar Lopez-Cedillo, Carlos Garcia-Perez, Muhammad Kashif, Virgilio Bocanegra-Garcia, Benjamin Nogueda-Torres, Gildardo Rivera   +7 more
doaj   +1 more source

DB75, a Novel Trypanocidal Agent, Disrupts Mitochondrial Function in Saccharomyces cerevisiae [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACT The aromatic diamidines represent a class of compounds with broad-spectrum antimicrobial activity; however, their development is hindered by a lack of understanding of their mechanism of antimicrobial action. DB75 [2,5-bis(4-amidinophenyl)furan] is a trypanocidal aromatic diamidine that was originally developed as a ...
Charlotte A, Lanteri, Bernard L, Trumpower, Richard R, Tidwell, Steven R, Meshnick   +3 more
openaire   +2 more sources

Additional Evidence of the Trypanocidal Action of (−)-Elatol on Amastigote Forms through the Involvement of Reactive Oxygen Species

Marine Drugs, 2014
Chagas’ disease, a vector-transmitted infectious disease, is caused by the protozoa parasite Trypanosoma cruzi. Drugs that are currently available for the treatment of this disease are unsatisfactory, making the search for new chemotherapeutic agents a ...
Vânia Cristina Desoti, Danielle Lazarin-Bidóia, Daniela Bueno Sudatti, Renato Crespo Pereira, Tania Ueda-Nakamura, Celso Vataru Nakamura, Sueli de Oliveira Silva   +6 more
doaj   +1 more source

A Clinical and Epidemiological Investigation of the First Reported Human Infection With the Zoonotic Parasite Trypanosoma evansi in Southeast Asia [PDF]

, 2016
Background. Trypanosoma is a genus of unicellular parasitic flagellate protozoa. Trypanosoma brucei species and Trypanosoma cruzi are the major agents of human trypanosomiasis; other Trypanosoma species can cause human disease, but are rare.
Baker, S, Berto, A, Campbell, JI, Carrique-Mas, J, Chalermwong, P, Desquesnes, M, Franco, JR, Herder, S, Jittapalapong, S, Le, BC, Nga, TVT, Ngo, TH, Ngo, TT, Nguyen, CT, Nguyen, KC, Nguyen, PHL, Nguyen, VC, Nguyen, VMH, Nguyen, VVC, Rabaa, MA, Tam, PTT, Thwaites, GE, Tran, TH, Wills, B, Yacoub, S, Yimming, B   +25 more
core   +1 more source

Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents. [PDF]

Chembiochem
All‐cis‐fluorinated cyclohexyl motifs with progressively increasing levels of fluorine are introduced into the WKYMVm peptide and a class of keto‐piperazine derivatives and assayed against the FPR2 receptor or the parasite Trypanosoma brucei, respectively.
He M, Thomson CM, Thompson D, Kuodis V, Smith TK, Dall'Angelo S, O'Hagan D.   +6 more
europepmc   +2 more sources

Synthesis of New Isoxazolylnaphthoquinones as Potential Trypanocidal and Antibacterial Agents [PDF]

Journal of Chemical Research, 1999
The synthesis of three new isoxazolylnaphthoquinones with an ethyl group on the isoxazole ring is reported.
Gladys E. Granero, María M. de Bertorello, Margarita C. Briñón   +2 more
openaire   +1 more source

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer, Agbe, Bruhn, Brun, Cristodero, Dean, Deterding, Herbert, Hoare, Holmes, Kaminsky, Lai, Lanteri, M. K. Gould, Mathis, Mukherjee, Painter, Priest, Roy Chowdhury, Räz, Schnaufer, Schnaufer, Schnaufer, Shapiro, Stuart, Tang, Thuita, Ward, Wenzler, Wenzler, Wilson, Zhang, Zuma   +32 more
core   +1 more source

Synthesis of indazol‐4,7‐dione derivatives as potential trypanocidal agents

Journal of Heterocyclic Chemistry, 2002
AbstractThe synthesis of new indazol‐4,7‐dione derivatives via 1,3‐dipolar cycloaddition of diazomethane with 2,3‐dimethyl‐1,4‐benzoquinone (2) and 1,4‐naphthoquinone (7) followed by N‐alkylation of the pyrazol nitrogen atom of the corresponding quinones (3) and (8) with methyl chloroacetate is described.
Tapia Apati, Ricardo, Carrasco, Claudia, Ojeda, Scarlet, Salas Sánchez, Cristián Osvaldo, Valderrama Guerrero, Jaime Adolfo, Morello, Antonio, Repetto, Yolanda   +6 more
openaire   +4 more sources

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity [PDF]

Arch Pharm (Weinheim)
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Mousavi A, Slapničková M, Norouzbahari M, D'Alessandro S, Foroumadi P, Peytam F, Perego F, Doleželová E, Emamgholipour Z, Tehrani M, Sadat‐Ebrahimi S, Hosseinzadeh E, Ahadi E, Firoozpour L, Bijanzadeh H, Basilico N, Zíková A, Foroumadi A.   +17 more
europepmc   +2 more sources

Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated
Alexandra Ibáñez-Escribano, Cristina Fonseca-Berzal, Mónica Martínez-Montiel, Manuel Álvarez-Márquez, María Gómez-Núñez, Manuel Lacueva-Arnedo, Teresa Espinosa-Buitrago, Tania Martín-Pérez, José Antonio Escario, Penélope Merino-Montiel, Sara Montiel-Smith, Alicia Gómez-Barrio, Óscar López, José G. Fernández-Bolaños   +13 more
doaj   +1 more source