Results 61 to 70 of about 7,518 (197)

The trans-Sialidase from Trypanosoma cruzi a Putative Target for Trypanocidal Agents [PDF]

The Open Parasitology Journal, 2010
Trypanosomatid protozoa are parasites of considerable medical and economical importance because they are the causative agents of chronic human and livestock diseases endemic in developing countries. Trypanosoma cruzi is the causative agent of Chagas´ disease, present in most of Latin America. The biology of this parasite presents some unusual features,
Lucia Mendonça-Previato, Adriane Regina Todeschini, Leonardo Freire de Lima, Jose Osvaldo Previato   +3 more
openaire   +1 more source

Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira, L. da Silva Lara, S. da Costa Lanera, T. Pérez de Souza, M. C. de Souza Pereira, G. L. Delogu, M. Silva dos Santos, M. J. Matos   +7 more
wiley   +1 more source

Development of a Quantitative Method for Detection of Multiclass Veterinary Drugs in Feed Using Modified QuPPe Extraction and LC–MS/MS

Molecules, 2022
A method was developed for the rapid and quantitative analysis of 30 veterinary drugs belonging to 17 classes (amphenicols (1), anthelmintics (1), cephalosporins (4), coccidiostats (1), lincosamides (1), macrolide (1), nitroimidazole (1), penicillins (3),
Sunyeong Jang, Hyungju Seo, Hojin Kim, Hyoyoung Kim, Jongsung Ahn, Hyunjeong Cho, Sunghie Hong, Seunghwa Lee, Taewoong Na   +8 more
doaj   +1 more source

Antiprotozoal activity of flavonoids from Eupatorium arnottianum [PDF]

, 2017
Dichloromethane and ethanol extracts of Eupatorium arnottianum were evaluated for invitroleishmanicidal activity. The dichloromethane extract produced 80% and 85% of growthinhibition on both Leishmania mexicana and Leishmania amazonensis promastigotes ...
Cazorla, Silvia Ines, Clavin, Maria Liliana, Frank, Fernanda María, Malchiodi, Emilio Luis, Martino, Virginia Susana, Muschietti, Liliana Victoria, Sosa, Miguel Angel, Spina Zapata, Renata María   +7 more
core  

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 [PDF]

, 2014
The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp.
Abedawn I. Khalaf, Addie M., Arcari J. T., Baker N., Barrett M. P., Barrett M. P., Bridges D. J., Brun R., Bursavich M. G., Carter N. S., Cavazzuti A., Colin J. Suckling, Colin L. Gibson, Creek D. J., Dawson A., Dincer S., Federica Giordani, Gangjee A., Gibson C. L., Gourley D. G., Judith K. Huggan, Kaspersen S. J., Keri L. Barrack, Kirsten Stewart, Le Brazidec J.-Y., Matovu E., Michael P. Barrett, Mohamed M. S., Mpamhanga C. P., Pui Ee Wong, Raz B., Sienkiewicz N., Simarro P. P., Spinks D., Tari L. W., Taylor E. C., Tessier P. R., Trzoss M., Tulloch L. B., William N. Hunter, Xie H., Zhu G.   +41 more
core   +5 more sources

Trypanosoma cruzi: analysis of two different strains after piplartine treatment

Brazilian Journal of Infectious Diseases, 2018
The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas' disease.
Gabriela Alves Licursi Vieira, Marco Túlio Alves da Silva, Luis Octávio Regasini, Fernando Cotinguiba, Helen Julie Laure, José César Rosa, Maysa Furlan, Regina Maria Barretto Cicarelli   +7 more
doaj   +3 more sources

Trypanosoma brucei: trypanocidal and cell swelling activities of lasalocid acid [PDF]

, 2017
Chemotherapeutic treatment of human and animal trypanosomaisis is unsatisfactory because only a few drugs are available. As these drugs have poor efficacy and cause adverse reactions, more effective and tolerable medications are needed.
Huczyński, Adam, Steverding, Dietmar
core   +1 more source

Acrylonitrile Derivatives against Trypanosoma cruzi: In Vitro Activity and Programmed Cell Death Study

Pharmaceuticals, 2021
The neglected infection known as Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, results in more than 7000 deaths per year, with an increasing number of cases in non-endemic areas such as Europe or the United States.
Carlos J. Bethencourt-Estrella, Samuel Delgado-Hernández, Atteneri López-Arencibia, Desirée San Nicolás-Hernández, Ines Sifaoui, David Tejedor, Fernando García-Tellado, Jacob Lorenzo-Morales, José E. Piñero   +8 more
doaj   +1 more source

Application of magnetically induced hyperthermia on the model protozoan Crithidia fasciculata as a potential therapy against parasitic infections

, 2012
Magnetic hyperthermia is currently an EU-approved clinical therapy against tumor cells that uses magnetic nanoparticles under a time varying magnetic field (TVMF).
Asín, L., Goya, G. F., Grazú, V., Ibarra, M. R., Marquina, C., Moros, M., Silber, A. M., Torres, T. E.   +7 more
core   +1 more source

Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents

Molecules, 2015
African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally.
Ngozi Justina Nwodo, Akachukwu Ibezim, Fidele Ntie-Kang, Michael Umale Adikwu, Chika John Mbah   +4 more
doaj   +1 more source