Results 51 to 60 of about 7,518 (197)

Benzopyrazine-Based Small Molecule Inhibitors As Trypanocidal and Leishmanicidal Agents: Green Synthesis, In Vitro, and In Silico Evaluations

Frontiers in Chemistry, 2021
World Health Organization (WHO) identified twenty tropical disease categories as neglected tropical diseases (NTDs)1. Chagas’ disease (also known as American trypanosomiasis) and leishmaniasis are two major classes of NTDs. The total number of mortality,
Jonathan Rock, Daniel Garcia, Omar Espino, Shaila A. Shetu, Manuel J. Chan-Bacab, Rosa Moo-Puc, Navin B. Patel, Gildardo Rivera, Debasish Bandyopadhyay, Debasish Bandyopadhyay   +9 more
doaj   +1 more source

In vitro activity of salinomycin and monensin derivatives against Trypanosoma brucei [PDF]

, 2016
Background: African trypanosomes are the causative agents of sleeping sickness in humans and nagana disease in livestock animals. As the few drugs available for treatment of the diseases have limited efficacy and produce adverse reactions, new and better
A Huczyński, A Huczyński, A Huczyński, A Huczyński, A Huczyński, A Huczyński, A Scherzad, Adam Huczyński, AH Fairlamb, D Steverding, DH Molyneux, Dietmar Steverding, E Matovu, GE Moore, H Hirumi, K Merschjohann, M Antoszczak, M Antoszczak, Michał Antoszczak, S Nwaka, SJ Collins, SV Barrett, T Baltz, V Delespaux, W Huber   +24 more
core   +1 more source

2-(Nitroaryl)-5-Substituted-1,3,4-Thiadiazole Derivatives with Antiprotozoal Activities: In Vitro and In Vivo Study

Molecules, 2022
Nitro-containing compounds are a well-known class of anti-infective agents, especially in the field of anti-parasitic drug discovery. HAT or sleeping sickness is a neglected tropical disease caused by a protozoan parasite, Trypanosoma brucei.
Alireza Mousavi, Parham Foroumadi, Zahra Emamgholipour, Pascal Mäser, Marcel Kaiser, Alireza Foroumadi   +5 more
doaj   +1 more source

Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]

, 2016
Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P., Hofer, Anders, Pavlova, Anna, Ranjbarian, Farahnaz, Vodnala, Munender   +4 more
core   +1 more source

Nifurtimox versus benznidazole or placebo for asymptomatic Trypanosoma cruzi infection (Equivalence of Usual Interventions for Trypanosomiasis - EQUITY): study protocol for a randomised controlled trial

Trials, 2019
Background Either benznidazole (BZN) or nifurtimox (NFX) is recommended as equivalent to treat Trypanosoma cruzi infection. Nonetheless, supportive data from randomised trials is limited to individuals treated with BZN in southern cone countries of Latin
Juan Carlos Villar, Víctor Mauricio Herrera, Juan Guillermo Pérez Carreño, Eliana Váquiro Herrera, Yeny Zulay Castellanos Domínguez, Skarlet Marcell Vásquez, Zulma Milena Cucunubá, Nilda Graciela Prado, Yolanda Hernández   +8 more
doaj   +1 more source

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

Pharmaceuticals, 2022
The genus Arrabidaea, consisting of ~170 species, belongs to the family Bignoniaceae, distributed around the Neotropics and temperate zone. The center of diversity of the family is in Brazil, where 56 genera and about 340 species exist.
Jessyane Rodrigues do Nascimento, Amanda de Jesus Alves Miranda, Felipe Costa Vieira, Carla Daniele Pinheiro Rodrigues, Luna Nascimento Vasconcelos, José Lima Pereira Filho, Auxiliadora Cristina Corrêa Barata Lopes, Marcelo Marucci Pereira Tangerina, Wagner Vilegas, Cláudia Quintino da Rocha   +9 more
doaj   +1 more source

Chemical and biological analysis of 4-acyloxy-3-nitrocoumarins as trypanocidal agents

Arabian Journal of Chemistry, 2021
Chagas disease is the most widespread contagious tropical disease in Latin America, being an important public health problem. Treatments against this disease are still very ineffective, presenting several side effects. Therefore, the search for alternative therapeutic solutions is urgent.
Francisco Salgado, Mauricio Moncada-Basualto, Josue Pozo-Martinez, Ana Liempi, Ulrike Kemmerling, Juan-Diego Maya, Pablo Jaque, Fernanda Borges, Eugenio Uriarte, Maria J. Matos, Claudio Olea-Azar   +10 more
openaire   +3 more sources

In Vitro Evaluation of Arylsulfonamide Derivatives against Trypanosoma cruzi

Drugs and Drug Candidates, 2023
Chagas disease is caused by the parasite protozoan Trypanosoma cruzi (T. cruzi) and affects millions of people in over 21 countries in around the world.
Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Jason Guy Taylor   +2 more
doaj   +1 more source

Trypanocidal activity of methanol extracts of the hemolymph of Sarcophaga argyrostoma larva against Trypanosoma evansi infected mice [PDF]

Veterinary World, 2020
Background and Aim: Many natural products worldwide are used for medicinal purposes. Various insect-isolated compounds were investigated in pursuit of new therapeutic agents.
Doaa S. Farghaly, Al-Shaimaa M. Sadek
doaj   +1 more source

Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs. [PDF]

, 2012
Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I nitroreductases, enzymes found ...
Alsford, Alsford, Armstrong, Begleiter, Belinda S. Hall, Bern, Bienen, Bot, Brun, Bryant, Chaudhuri, Chen, Clarkson, Danson, Danson, Emma Louise Meredith, Ernster, Faeder, Fang, Fang, Fang, Fang, Garavaglia, Gascon, Goodwin, Guerra, Hall, Hall, Hall, Henderson, Hirumi, Hoet, Hu, Iyanagi, Jaiswal, Jarrom, Koder, Kubata, Müller, Nillius, Nivinskas, Nixon, O'Brien, Pal, Parkinson, Peterson, Pinto, Powis, Purkayastha, Race, Race, Ramos, Rassi, Shane R. Wilkinson, Stein, Stuart, Surve, Tatsumi, Tedeschi, Torri, Torri, Urech, Ward, Watanabe, Whiteway, Wilkinson, Yan, Zenno, Zenno   +68 more
core   +1 more source