Results 1 to 10 of about 1,018 (177)

Cruzain Inhibition by Terpenoids: A Molecular Docking Analysis [PDF]

Natural Product Communications, 2008
A molecular docking analysis has been carried out using monoterpene and sesquiterpene hydrocarbons and triterpenoids that have shown enzyme inhibitory activity as ligands for the cysteine protease cruzain.
Ifedayo V. Ogungbe, William N. Setzer
doaj   +2 more sources

Inhibition of Cruzain by Triterpenoids Isolated from a from Monteverde, Costa Rica

Natural Product Communications, 2007
The crude chloroform bark extract of an undescribed species of Salacia from Monteverde, Costa Rica, showed cruzain inhibitory activity (IC 50 = 11.4 ± 0.6 μg/mL).
Brittany R. Agius, Bernhard Vogler, Sean L. Stokes, William N. Setzer, Conor R. Caffrey, Elizabeth Hansell, James H. McKerrow   +6 more
doaj   +1 more source

3--(3′-Hydroxytetradecanoyl)lupeol from Inhibits Cruzain

Natural Product Communications, 2007
The crude chloroform extract from the stem bark of Sorocea trophoides (Moraceae) showed in-vitro inhibition of the cysteine protease cruzain. Activity-directed fractionation led to isolation of the novel 3- O -(3′-hydroxytetradecanoyl)lupeol as the ...
Lori R. Richter, Bernhard Vogler, Ashley F. Penton, William N. Setzer, William A. Haber, Conor R. Caffrey, Elizabeth Hansell, James H. McKerrow   +7 more
doaj   +1 more source

Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents.

PLoS Neglected Tropical Diseases, 2020
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. A series of 26 new compounds were designed, synthesized, and tested against the recombinant cruzain (Cz) to map its S1/
Lorenzo Cianni, Carina Lemke, Erik Gilberg, Christian Feldmann, Fabiana Rosini, Fernanda Dos Reis Rocho, Jean F R Ribeiro, Daiane Y Tezuka, Carla D Lopes, Sérgio de Albuquerque, Jürgen Bajorath, Stefan Laufer, Andrei Leitão, Michael Gütschow, Carlos A Montanari   +14 more
doaj   +1 more source

Chemical Compositions and Biological Activities of Leaf Essential Oils of Twelve Species of from Monteverde, Costa Rica

Natural Product Communications, 2008
The leaf essential oils of twelve species of Piper (Piperaceae) from Monteverde, Costa Rica ( Piper aequale, Piper amalago, Piper biasperatum, Piper bredemeyeri, Piper dotanum, Piper fimbriulatum, Piper glabrescens, Piper imperiale, Piper lanceifolium ...
William N. Setzer, Grace Park, Brittany R. Agius, Sean L. Stokes, Tameka M. Walker, William A. Haber   +5 more
doaj   +1 more source

Two approaches to discovering and developing new drugs for Chagas disease

Memorias do Instituto Oswaldo Cruz, 2009
This review will focus on two general approaches carried out at the Sandler Center, University of California, San Francisco, to address the challenge of developing new drugs for the treatment of Chagas disease.
JH McKerrow, PS Doyle, JC Engel, LM Podust, SA Robertson, R Ferreira, T Saxton, M Arkin, ID Kerr, LS Brinen, CS Craik   +10 more
doaj   +1 more source

Computational and Investigative Study of Flavonoids Active against and spp

Natural Product Communications, 2015
Flavonoid compounds active against Trypanosoma cruzi and Leishmania species were submitted to several methodologies in silico : docking with the enzymes cruzain and trypanothione reductase (from T.
Frederico F. Ribeiro, Francisco J.B.M. Junior, Marcelo S. da Silva, Marcus Tullius Scotti, Luciana Scotti   +4 more
doaj   +1 more source

Design, synthesis and identification of novel molecular hybrids based on naphthoquinone aromatic hydrazides as potential trypanocide and leishmanicidal agents

Anais da Academia Brasileira de Ciências
In pursuit of potential agents to treat Chagas disease and leishmaniasis, we report the design, synthesis, and identification novel naphthoquinone hydrazide-based molecular hybrids.
ROSANE D. CEZAR, ADRIANO O. DA SILVA, ROSÂNGELA S. LOPES, CELSO V. NAKAMURA, JEAN HENRIQUE S. RODRIGUES, ESTELA MARIANA G. LOURENÇO, SUMBAL SABA, ADILSON BEATRIZ, JAMAL RAFIQUE, DÊNIS P. DE LIMA   +9 more
doaj   +1 more source

Metal-based compounds and Chagas disease treatment: current knowledge and therapeutic perspectives

Frontiers in Drug Discovery
Chagas disease (CD) is a parasitic infection caused by the protozoan Trypanosoma cruzi. CD treatment is restricted to benznidazole (BZN) and nifurtimox, with the former being the treatment of choice in many countries.
Vitor Klipel da Silva Bertolini, Jennyfer Castro, Josielle Vieira Fontes, Camilla Abbehausen, Fernanda Ramos Gadelha   +4 more
doaj   +1 more source

Impact of the Recognition Part of Dipeptidyl Nitroalkene Compounds on the Inhibition Mechanism of Cysteine Proteases Cruzain and Cathepsin L. [PDF]

ACS Catal, 2023
Arafet K, Royo S, Schirmeister T, Barthels F, González FV, Moliner V.   +5 more
europepmc   +1 more source