Results 41 to 50 of about 1,668 (161)

Cruzain Inhibitory Activity of the Leaf Essential Oil from an Undescribed Species of from Monteverde, Costa Rica

Natural Product Communications, 2007
The leaf essential oil of Eugenia sp. nov. “San Bosco” inhibits cruzain, a cysteine protease from Trypanosoma cruzi, the parasitic protozoan responsible for Chagas disease, with an IC 50 of 36.4 μg/mL.
Sean L. Stokes, Ramona A. Cole, Mariana P. Rangelova, William A. Haber, William N. Setzer   +4 more
doaj   +1 more source

Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica [PDF]

, 2008
The helminth parasite Fasciola hepatica secretes cysteine proteases to facilitate tissue invasion, migration, and development within the mammalian host.
Brinen, LS, Caffrey, CR, Collins, PR, Craik, CS, Dalton, JP, Donnelly, SM, Geiger, SR, Lowther, J, Marion, R, McKerrow, JH, Robinson, MW, Seshaadri, A, Stack, CM, Tort, JF, Xu, W   +14 more
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Organometallic gold(III) complexes with tridentate halogen‐substituted thiosemicarbazones: Effects of halogenation on cytotoxicity and anti‐parasitic activity [PDF]

, 2019
Chemical properties and biological activity of Au(III) compounds obtained from dichlorido[2‐(dimethylaminomethyl)phenyl‐C1,N]gold(III), [Au(damp‐C1,N)Cl2], and halogenated, potentially tridentate thiosemicarbazones have been studied.
Abram, Ulrich, Albuquerque, Sérgio de, Goulart, Amanda, Hagenbach, Adelheid, Jungfer, Maximilian Roca, Portapilla, Gisele Bulhões, Salsi, Federico, Schutjajew, Konstantin   +7 more
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Cruzain Inhibitory Activity of Leaf Essential Oils of Neotropical Lauraceae and Essential Oil Components

Natural Product Communications, 2007
The leaf essential oils of twenty-three species of Lauraceae from Monteverde, Costa Rica, have been screened for inhibition of the cysteine protease cruzain.
William N. Setzer, Sean L. Stokes, Ashley F. Penton, Sayaka Takaku, William A. Haber, Elizabeth Hansell, Conor R. Caffrey, James H. McKerrow   +7 more
doaj   +1 more source

Perspectives on the Trypanosoma cruzi-host cell receptor interaction [PDF]

, 2009
Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions.
A Belley, A Buschiazzo, AC Frasch, AC Monteiro, AC Monteiro, AG Todorov, AJS Augustine, AK Vaidian, AL Leal, AM Celentano, AM Silber, AM Woolsey, Anthony W. Ashton, AP Lima, AW Ashton, AW Ashton, BA Burleigh, BA Burleigh, BA Burleigh, BK Kubata, C Claser, CA Buscaglia, CA Petersen, CW Turner, E Del Nery, E Ortega-Barria, F Leeb-Lundberg, F Marceau, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, Fabiana S. Machado, Fangxia Guan, Fernando Villalta, GS Hassan, HB Tanowitz, HB Tanowitz, HB Tanowitz, HB Tanowitz, Herbert B. Tanowitz, Huan Huang, IC Cuevas, IM Bastos, J Aliberti, J Scharfstein, J Scharfstein, JC Engel, JL Croxford, JM Di Noia, Julio Scharfstein, K Kabashima, KD Bhoola, Kevin M. Tyler, KJ Simmons, KM Tyler, L Sterin-Borda, LO Andrade, Louis M. Weiss, LX Liu, M de Melo-Jorge, M Einicker-Lamas, M Ming, MA Campos, MA Ouaissi, Maria F. Lima, MC Taylor, ME McGrath, MF Lima, MF Lima, MH Magdesian, MJ Alves, MN Meirelles, MV Chuenkova, MV Chuenkova, MV Chuenkova, MV Chuenkova, N Garg, N Garg, N Yoshida, P Grellier, PJ Pereira, PN Nde, R Agusti, R Giordano, R Manning-Cela, RA Skidgel, RL Cardoni, S Favoreto Jr, S Mukherjee, S Mukherjee, S Mukherjee, S Schenkman, S Vaena de Avalos, Sandra Alvarez, SB Petkova, SB Petkova, SG Andrade, Shankar Mukherjee, SM Factor, T Moody, VL Hideko Tatakihara, YY Kleshchenko   +108 more
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Contribution of microscopy for understanding the mechanism of action against trypanosomatids [PDF]

, 2018
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs.
A Martinez-Palomo, A Montalvetti, A Rassi, AB Penissi, AE Eakin, AH Kolien, AJ Solari, AM Sánchez, Ana Yecê das Neves Pinto, C Brack, CF Silva Da, D Gonzalez-Pacanowska, DA Campbell, DA Johnston, DJ Hammond, DV Andrade, E Bontempi, E Lozano, E Lozano, E Lozano, EO Ogbadoiyi, ES Garcia, ES Lozano, F Dos Reis, FR Opperdoes, FR Opperdoes, FR Opperdoes, FS Laranja, H Meyer, H Meyer, J Aldunate, J Lukes, J McKerrow, J Mottram, JA Urbina, JA Urbina, JA Urbina, JA Urbina, JC Engel, JC Linder, JCP Dias, JCP Dias, JD Bergstrom, JD Maya, JF Turrens, JJ Marr, JL Avila, JL Avila, Juliano de Toledo, K Lazardi, K Miranda, K Miranda, KH Lee, L Simpson, LV Muschietti, M Meirelles, M Nieto, MC Elias, MCQB Elias, MR Ariyanayagam, MR Ariyanayagam, NM Sayed El, O Campetella, OS Giordano, OS Giordano, P Barrera, P Webster, PF Pimenta, R Docampo, S Sepúlveda-Boza, SD Brengio, SR Wilkinson, T Souto-Padron, T Souto-Padron, T Souto-Padron, T Souto-Padron, TA Shapiro, TS Tiuman, V Jimenez-Ortiz, V Sülsen, VP Sülsen, VP Sülsen, VV Costantino, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, Wanderley de Souza, WE Gutteridge   +90 more
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Chemical Composition and Cruzain Inhibitory Activity of Bark Essential Oil from Monteverde, Costa Rica

Natural Product Communications, 2007
American trypanosomiasis, Chagas disease, is a great cause of human morbidity and mortality in the Neotropics. Although there is currently no effective treatment for this parasitic disease, a number of potential biochemical targets have been identified ...
William N. Setzer, Sean L. Stokes, Anita Bansal, William A. Haber, Conor R. Caffrey, Elizabeth Hansell, James H. McKerrow   +6 more
doaj   +1 more source

A yeast gene (BLH1) encodes a polypeptide with high homology to vertebrate bleomycin hydrolase, a family member of thiol proteinases [PDF]

, 1993
We have purified bleomycin hydrolase from yeast (molecular mass 55 000 Da). Using protein sequence-derived degenerate oligonucleotide primers and amplification by polymerase chain reaction, the yeast gene BLH1 was isolated and characterized.
Akiyama, Bennetzen, Buchman, Devereux, Eakin, George, Higgins, Lazo, Lazo, Magdolen, Müller, Ohno, Pears, Povirk, Ritonja, Sebti, Sikorski, Umezawa, Watanabe   +18 more
core   +1 more source

Kinetic Studies of Potent Thiosemicarbazone Inhibitors of Cruzain

The FASEB Journal, 2007
Cruzain, a cathepsin L‐ and B‐like enzyme, is the major cysteine protease from Trypanosoma cruzi , the causative agent of Chagas' disease which is a major public health problem in Latin America. Previously, we reported a small library of thiosemicarbazone derivatives as inhibitors of cruzain.
Shen‐En Chen, Rogelio E. Siles, Ming Zhou, Wara Milenka Arispe, Hanna Lee, Kevin G. Pinney, Mary Lynn Trawick   +6 more
openaire   +1 more source

Subverting lysosomal function in Trypanosoma brucei. [PDF]

, 2015
In this issue of Microbial Cell, Koh and colleagues present data highlighting the utility of the lysosomotropic compound L-leucyl-L-leucyl methyl ester (LeuLeu-OMe) as an anti-Trypanosoma brucei agent, adding to the range of compounds that either ...
Alsford, Sam
core   +3 more sources