Adaptive evolution and divergence of SERPINB3: a young duplicate in great Apes [PDF]
, 2014 A series of duplication events led to an expansion of clade B Serine Protease Inhibitors (SERPIN), currently displaying a large repertoire of functions in vertebrates.
Gomes, Silvia +3 more
core +9 more sources
Fibronectin-Degrading Activity of Trypanosoma cruzi Cysteine Proteinase Plays a Role in Host Cell Invasion [PDF]
, 2014 Trypanosoma cruzi, the agent of Chagas disease, binds to diverse extracellular matrix proteins. Such an ability prevails in the parasite forms that circulate in the bloodstream and contributes to host cell invasion.
Cortez, Cristian +4 more
core +2 more sources
Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum. [PDF]
PLoS ONE, 2009 Falcipain-2, a papain family cysteine protease of the malaria parasite Plasmodium falciparum, plays a key role in parasite hydrolysis of hemoglobin and is a potential chemotherapeutic target.
Kailash C Pandey +3 more
doaj +1 more source
CHARACTERIZATION AND ANTIPARASITIC ACTIVITY OF BENZOPHENONE THIOSEMICARBAZONES ON Trypanosoma brucei brucei [PDF]
, 2011 The structure of four synthesized thiosemicarbazones, substituted or not, of benzophenone has been confirmed by spectrometrical analysis IR, NMR 1H and 13C. Their anti-trypanosomal activities were evaluated on Trypanosoma brucei brucei.
Bienvenu Glinma +5 more
core
Genetic Vaccination against Experimental Infection with Myotropic Parasite Strains of Trypanosoma cruzi [PDF]
, 2014 In earlier studies, we reported that a heterologous prime-boost regimen using recombinant plasmid DNA followed by replication-defective adenovirus vector, both containing Trypanosoma cruzi genes encoding trans-sialidase (TS) and amastigote surface ...
Araujo, Adriano Fernando +10 more
core +5 more sources
Secretory pathway of trypanosomatid parasites [PDF]
, 2002 The Trypanosomatidae comprise a large group of parasitic protozoa, some of which cause important diseases in humans. These include Tryanosoma brucei (the causative agent of African sleeping sickness and nagana in cattle), Trypanosoma cruzi (the causative
McConville, Malcolm J. +3 more
core +1 more source
Inhibition of Cruzain by Triterpenoids Isolated from a from Monteverde, Costa Rica
Natural Product Communications, 2007 The crude chloroform bark extract of an undescribed species of Salacia from Monteverde, Costa Rica, showed cruzain inhibitory activity (IC 50 = 11.4 ± 0.6 μg/mL).
Brittany R. Agius +6 more
doaj +1 more source
3--(3′-Hydroxytetradecanoyl)lupeol from Inhibits Cruzain
Natural Product Communications, 2007 The crude chloroform extract from the stem bark of Sorocea trophoides (Moraceae) showed in-vitro inhibition of the cysteine protease cruzain. Activity-directed fractionation led to isolation of the novel 3- O -(3′-hydroxytetradecanoyl)lupeol as the ...
Lori R. Richter +7 more
doaj +1 more source
Analysis of novel low nanomolar thiosemicarbazone inhibitors of cruzain
The FASEB Journal, 2010 Chagas’ disease, caused by the protozoan Trypanosoma cruzi, affects millions of people in Latin America where it is a major cause of heart disease.
Gustavo Edgardo Chavarria +9 more
openaire +1 more source
PLoS Neglected Tropical Diseases, 2020 The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. A series of 26 new compounds were designed, synthesized, and tested against the recombinant cruzain (Cz) to map its S1/
Lorenzo Cianni +14 more
doaj +1 more source