Results 71 to 80 of about 1,668 (161)
Natural Product Communications, 2008 The leaf essential oils of twelve species of Piper (Piperaceae) from Monteverde, Costa Rica ( Piper aequale, Piper amalago, Piper biasperatum, Piper bredemeyeri, Piper dotanum, Piper fimbriulatum, Piper glabrescens, Piper imperiale, Piper lanceifolium ...
William N. Setzer +5 more
doaj +1 more source
Asymmetric Ion-Pairing Catalysis [PDF]
, 2014 Chemistry and Chemical ...
Brak, Katrien, Jacobsen, Eric N.
core +1 more source
Two approaches to discovering and developing new drugs for Chagas disease
Memorias do Instituto Oswaldo Cruz, 2009 This review will focus on two general approaches carried out at the Sandler Center, University of California, San Francisco, to address the challenge of developing new drugs for the treatment of Chagas disease.
JH McKerrow +10 more
doaj +1 more source
Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles [PDF]
, 2018 Chagas disease affects millions of people in Latin America. This disease is caused by the protozoan parasite Trypanossoma cruzi. The cysteine protease cruzain is a key enzyme for the survival and propagation of this parasite lifecycle.
Cianni, Lorenzo +7 more
core +2 more sources
El Trypanosoma Cruzi, parásito que causa la enfermedad de Chagas, modula la señalización inducida por interleuquina-6 a través de la degradación de receptor gp130 en diferentes células de huesped [PDF]
, 2013 Interleuquina-6 es una citoquina pleiotrópica que participa en la respuesta inmune y en la sobrevida de las células a través de la activación del factor de transcripción STAT3 vía el receptor transductor de señales (gp)130.
Aoki, Maria del Pilar +3 more
core
Computational and Investigative Study of Flavonoids Active against and spp
Natural Product Communications, 2015 Flavonoid compounds active against Trypanosoma cruzi and Leishmania species were submitted to several methodologies in silico : docking with the enzymes cruzain and trypanothione reductase (from T.
Frederico F. Ribeiro +4 more
doaj +1 more source
Anais da Academia Brasileira de CiênciasIn pursuit of potential agents to treat Chagas disease and leishmaniasis, we report the design, synthesis, and identification novel naphthoquinone hydrazide-based molecular hybrids.
ROSANE D. CEZAR +9 more
doaj +1 more source
Journal of CheminformaticsWe developed SPARFlow, an open-source KNIME workflow for structure–activity or structure–property relationship (SAR/SPR) analyses. The workflow integrates data preprocessing, chemical structure curation, similarity network construction, maximum common ...
Elier E. Abreu-Martínez +2 more
doaj +1 more source
La click-chemistry en el descubrimiento de fármacos [PDF]
, 2016 La revisión bibliográfica que se presenta a continuación trata sobre la llamada clickchemistry y su aplicación en el descubrimiento de fármacos. Para ello se parte de la definición de click-chemistry y sus principales características que la hacen ...
González Vázquez, María
core
Metal-based compounds and Chagas disease treatment: current knowledge and therapeutic perspectives
Frontiers in Drug DiscoveryChagas disease (CD) is a parasitic infection caused by the protozoan Trypanosoma cruzi. CD treatment is restricted to benznidazole (BZN) and nifurtimox, with the former being the treatment of choice in many countries.
Vitor Klipel da Silva Bertolini +4 more
doaj +1 more source