Results 71 to 80 of about 1,018 (177)
Antibiotics, 2021 Metal-based drugs, including lanthanide complexes, have been extremely effective in clinical treatments against various diseases and have raised major interest in recent decades. Hence, in this work, a series of lanthanum (III) and cerium (III) complexes,
Alberto Aragón-Muriel +7 more
doaj +1 more source
Structure‐Function of Falcipains: Malarial Cysteine Proteases
Journal of Tropical Medicine, Volume 2012, Issue 1, 2012., 2012 Evidence indicates that cysteine proteases play essential role in malaria parasites; therefore an obvious area of investigation is the inhibition of these enzymes to treat malaria. Studies with cysteine protease inhibitors and manipulating cysteine proteases genes have suggested a role for cysteine proteases in hemoglobin hydrolysis.
Kailash C. Pandey +2 more
wiley +1 more source
Journal of Parasitology Research, Volume 2012, Issue 1, 2012., 2012 Parasitic protozoa are among the most important pathogens worldwide. Diseases such as malaria, leishmaniasis, amoebiasis, giardiasis, trichomoniasis, and trypanosomiasis affect millions of people. Humans are constantly threatened by infections caused by these pathogens.
Carolina Piña-Vázquez +5 more
wiley +1 more source
Electrochemical Multicomponent Synthesis of Alkyl Alkenesulfonates using Styrenes, SO2 and Alcohols
Chemistry – A European Journal, Volume 30, Issue 21, April 11, 2024.A first of its kind electrochemical approach for the direct synthesis of alkyl alkenesulfonates using styrenes, SO2 stock solution and alcohols was developed. The reaction features the in‐situ generation of a monoalkylsulfite species with subsequent radical addition to an anodically oxidized styrene substrate.
Aloisio de A. Bartolomeu +4 more
wiley +1 more source
Structure of WRR-483 bound to cruzain
, 2013 . (A) Crystallographic unit of the WRR-483-cruzain complex. (B) View of the active site of cruzain. The catalytic Cys25 and residues involved in binding to the inhibitor are also shown. Figures prepared with PyMol.
Yen Ting Chen (361838) +6 more
core +1 more source
Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum. [PDF]
PLoS ONE, 2009 Falcipain-2, a papain family cysteine protease of the malaria parasite Plasmodium falciparum, plays a key role in parasite hydrolysis of hemoglobin and is a potential chemotherapeutic target.
Kailash C Pandey +3 more
doaj +1 more source
pH dependence of cruzain inhibition.
, 2013 pH dependence of cruzain inhibition.
Yen Ting Chen (361838) +6 more
core +1 more source
, 2013 Recombinant human NF-κB P65 was treated or not with cruzain or parasite extracts. Lane 1, untreated control; lane 2, r-cruzain (1∶1 molar ratio); lanes 3–4: dilutions 1∶10 and 1∶100 of r-cruzain, respectively; lane 5, r-cruzain (1∶1 molar ratio) and 10 ...
Ivy Hsieh (174545) +5 more
core +1 more source
Kinetic Studies of Potent Thiosemicarbazone Inhibitors of Cruzain
The FASEB Journal, 2007 Cruzain, a cathepsin L‐ and B‐like enzyme, is the major cysteine protease from Trypanosoma cruzi , the causative agent of Chagas' disease which is a major public health problem in Latin America. Previously, we reported a small library of thiosemicarbazone derivatives as inhibitors of cruzain.
Shen‐En Chen +6 more
openaire +1 more source
Main interactions established between substrate and cruzain binding site.
, 2019 (A) cruzain-substrate (B) cruzain-peptide-compound 1 and (C) cruzain-peptide-compound 2. The interacting residues are labeled in each case and the relative position of ligand (yellow) with respect to substrate (lightorange) is represented in the right ...
Lilian Hernández Alvarez (739728) +3 more
core +1 more source