Results 91 to 100 of about 1,668 (161)

Evaluating the protonation state of the catalytic Cys25 in cruzain cysteine protease: A target for Chagas disease. [PDF]

Protein Sci
da Costa CHS, Bonatto V, Santos HBT, Souza CGDS, Montanari CA, Skaf MS, Luque FJ, Lameira J.   +7 more
europepmc   +1 more source

Open source drug discovery with the Malaria Box compound collection for neglected diseases and beyond [PDF]

, 2016
Dang, Na Le, et al.,, Hughes, Tyler B, Taramelli, Donatella   +3 more
core   +2 more sources

Investigation of the activity of 4-aminoquinolines as cysteine protease inhibitors with application in the treatment of Chagas disease. [PDF]

Mem Inst Oswaldo Cruz
Sheu-Idrees R, Marques GVL, Santana PAL, Diniz LA, Resende DM, Odoma S, Olorunshola O, Ferreira RS, Murta SMF, Maltarollo VG, de Oliveira RB.   +10 more
europepmc   +1 more source

Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases. [PDF]

J Med Chem, 2021
Li L, Chenna BC, Yang KS, Cole TR, Goodall ZT, Giardini M, Moghadamchargari Z, Hernandez EA, Gomez J, Calvet CM, Bernatchez JA, Bernatchez JA, Mellott DM, Zhu J, Rademacher A, Thomas D, Blankenship LR, Drelich A, Laganowsky A, Tseng CK, Liu WR, Wand AJ, Cruz-Reyes J, Siqueira-Neto JL, Meek TD.   +24 more
europepmc   +1 more source

Similarity-Based Profiling of Hydrazone-Containing Scaffolds Active Against <i>Leishmania</i> Amastigotes. [PDF]

ACS Omega
Pereira da Silva RY, Alves de Lima JL, Pinto SBA, I LC, Jordão AK, Barbosa EG.   +5 more
europepmc   +1 more source

Unraveling Common Patterns and Differences among Cruzipains through Molecular Dynamics Simulations and Structural Analyses. [PDF]

ACS Omega
Santos LHS, Broilo Campos AC, Corrêa Santos V, Fassio AV, Costa MGS, Ferreira RS.   +5 more
europepmc   +1 more source

Recent Progress in Thiazole, Thiosemicarbazone, and Semicarbazone Derivatives as Antiparasitic Agents Against Trypanosomatids and <i>Plasmodium</i> spp. [PDF]

Molecules
Souza Tada da Cunha P, Rodriguez Gini AL, Man Chin C, Dos Santos JL, Benito Scarim C.   +4 more
europepmc   +1 more source

Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities. [PDF]

Front Pharmacol, 2023
Porta EOJ, Kalesh K, Steel PG.
europepmc   +1 more source

TrypPROTACs Unlocking New Therapeutic Strategies for Chagas Disease. [PDF]

Pharmaceuticals (Basel)
Rodriguez Gini AL, Souza Tada da Cunha P, João EE, Man Chin C, Dos Santos JL, Serra EC, Benito Scarim C.   +6 more
europepmc   +1 more source

Protozoan Neglected Tropical Diseases (NTDs) Target Inhibition of Alkaloids from <i>Croton linearis</i> Jacq Leaves: A Molecular Docking and ADMET Approach. [PDF]

Pharmaceuticals (Basel)
Rojas-Vargas JA, García-Díaz J, Escalona-Arranz JC, Chlebek J, Monzote L, Setzer WN, Castillo-Garit JA.   +6 more
europepmc   +1 more source