Results 31 to 40 of about 1,668 (161)
Identification of Levothyroxine Antichagasic Activity through Computer-Aided Drug Repurposing [PDF]
, 2014 Cruzipain (Cz) is the major cysteine protease of the protozoan Trypanosoma cruzi, etiological agent of Chagas disease. A conformation-independent classifier capable of identifying Cz inhibitors was derived from a 163-compound dataset and later applied in
Alberca, Lucas Nicolás +5 more
core +8 more sources
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source
In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents [PDF]
, 2012 Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, we synthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. A broad selection of these compounds were submitted
Almerico, A. +3 more
core +1 more source
Pyrone-based inhibitors of metalloproteinase types 2 and 3 may work as conformation-selective inhibitors. [PDF]
, 2011 Matrix metalloproteinases are zinc-containing enzymes capable of degrading all components of the extracellular matrix. Owing to their role in human disease, matrix metalloproteinase have been the subject of extensive study.
de Oliveira, César AF +2 more
core +1 more source
Acta Crystallographica Section F Structural Biology Communications, 2019 Chagas disease, which is caused by Trypanosoma cruzi, affects more than six million people worldwide. Cruzain is the major cysteine protease involved in the survival of this parasite. Here, the expression, purification and crystallization of this enzyme are reported.
Elany, Barbosa da Silva +4 more
openaire +3 more sources
On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors
RSC Medicinal Chemistry, 2020 Aldehyde peptide like compounds display a bivalent reactive profile and improved antichagasic potency.
Vinicius Bonatto +12 more
openaire +3 more sources
The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi [PDF]
, 2006 Papain-like cysteine proteases are important for the survival of the flagellated protozoa Trypanosoma cruzi, the causative agent of Chagas' Disease.
Judice, Wagner AS +5 more
core +1 more source
Frontiers in Chemistry, 2019 Chagas disease causes ~10,000 deaths each year, mainly in Latin America, where it is endemic. The currently available chemotherapeutic agents are ineffective in the chronic stage of the disease, and the lack of pharmaceutical innovation for Chagas ...
Rafael A. A. Ferreira +10 more
doaj +1 more source
Current and future chemotherapy for Chagas disease [PDF]
, 2015 Luís Gaspar is thankful to FCT for funding (scholarship reference: SFRH/BD/81604/2011). The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreement No.602773 (Project KINDRED)
Cordeiro-da-Silva, Anabela +10 more
core +1 more source
Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]
, 2011 Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet +10 more
core +1 more source