Results 81 to 90 of about 3,959 (186)

Ethnomedical uses, chemical constituents, and evidence-based pharmacological properties of Chenopodium ambrosioides L.: extensive overview

Future Journal of Pharmaceutical Sciences, 2021
Background The Chenopodium genus is a plant family widely spread worldwide that includes various plant species reputed to possess several medicinal virtues in folk medicines. Chenopodium ambrosioides L.
Félicien Mushagalusa Kasali, Jonans Tusiimire, Justin Ntokamunda Kadima, Amon Ganafa Agaba   +3 more
doaj   +1 more source

Trypanocidal activity of Brazilian plants against epimastigote forms from Y and Bolivia strains of Trypanosoma cruzi [PDF]

, 2012
Chagas disease is one of the main public health problems in Latin America. Since the available treatments for this disease are not effective in providing cure, the screening of potential antiprotozoal agents is essential, mainly of those obtained from ...
Silva, Dulce Helena Siqueira [UNESP], Bolzani, Vanderlan da Silva, Funari, Cristiano Soleo [UNESP], Alves, Renata Tomé [UNESP], Silva, Dulce Helena Siqueira, Regasini, Luis Octávio, Funari, Cristiano Soleo, Regasini, Luis Octávio [UNESP], Rimoldi, Aline, Alves, Renata Tomé, Bolzani, Vanderlan da Silva [UNESP], Rosa, João Aristeu da [UNESP], Young, Maria Cláudia Marx, Albuquerque, Sérgio de, Rosa, João Aristeu da   +14 more
core   +1 more source

Ruthenium‐Catalyzed CH Alkenylation of Trypanocidal Naphthoquinones: A Mechanistic Benchmarking Study

ChemistryOpen, Volume 15, Issue 2, February 2026.
Computational roadmap to click‐ready quinones. Quantum chemical analysis reveals how substituents modulate the reactivity of trypanocidal naphthoquinones in Ru‐catalyzed CH alkenylation, guiding the design of sulfonyl‐fluoride scaffolds for next‐generation antiparasitic agents.
Esther R. S. Paz, Cauê P. Souza, Joyce C. De Oliveira, Renata G. Almeida, Chonny Herrera‐Acevedo, Sulaiman Lakoh, Guilherme A. M. Jardim, Eufrânio N. da Silva Júnior, Felipe Fantuzzi   +8 more
wiley   +1 more source

Antiprotozoal Activity of Quinonemethide Triterpenes from Maytenus ilicifolia (Celastraceae)

Molecules, 2013
The present study describes the leishmanicidal and trypanocidal activities of two quinonemethide triterpenes, maytenin (1) and pristimerin (2), isolated from Maytenus ilicifolia root barks (Celastraceae).
Maysa Furlan, Ana Maria Soares Pereira, Regina M. B. Cicarelli, Beatriz S. Stolf, Mariana Kolos Galuppo, Camila T. Nogueira, Isabel Martinez, Luis O. Regasini, Mariana da Costa Siqueira, Karoline M. Leite, Vania A. F. F. M. dos Santos, Marcia A. S. Graminha   +11 more
doaj   +1 more source

Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge haliclona simulans

, 2014
The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol.
Ooi, Thengtheng, Kennedy, Jonathan, Gráinne Abbott, Thengtheng Ooi, Abbott, Gráinne, Viegelmann, Christina, RuAngelie Edrada-Ebel, Parker, Jennifer, Dobson, Alan D W, Edrada-Ebel, RuAngelie, Jennifer Parker, Jonathan Kennedy, Carol Clements, Alan D. W. Dobson, Clements, Carol, Alan Dobson, Christina Viegelmann, Young, Louise, Louise Young   +18 more
core   +1 more source

Trypanocidal activities of trileucine methyl vinyl sulfone proteasome inhibitors

, 2005
Previous studies have shown that proteasome inhibitors are novel agents for chemotherapy of human African trypanosomiasis or sleeping sickness. In this study, five peptide trileucine methyl vinyl sulfones with different N-terminal substituents were ...
Steverding, Dietmar, Spackman, Robert W, Glenn, Robert J, Royle, Howard J   +3 more
core   +1 more source

Synthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi

ChemMedChem, Volume 21, Issue 1, January 2026.
Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco, Jodieh Oliveira Santana Varejão, Isabela Penna Ceravolo, Victória Miranda Machado, Antoniana Ursine Krettli, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Felipe Terra Martins, Eduardo Jorge Pilau, Vinícius Ribeiro Montes, Markus Kohlhoff, Eduardo V. V. Varejão   +11 more
wiley   +1 more source

Biosafety Evaluation of 6,7‐Dihydroxy‐3‐(2‐Nitrophenyl)Coumarin in Human Cells

Journal of Applied Toxicology, Volume 46, Issue 1, Page 198-206, January 2026.
ABSTRACT Coumarins are considered a privileged scaffold in medicinal chemistry, as they may interact with biological macromolecules, presenting several pharmacological properties. Their potential makes them an object of study for the evaluation of their safety for humans, which is essential in the design of a potential drug.
Júlia Zocca Nunes de Barros, Luma Eduarda Lopes Escalante, Maria João Matos, Edson Luis Maistro   +3 more
wiley   +1 more source

Seasonal Dynamics and Associated Risk Factors of Bovine Trypanosomosis and Its Vector in Selected Districts of Gamo and Gofa Zones, Southern Ethiopia

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
The median PCV of poor body‐conditioned animals is below 20 (anaemic) compared to corresponding body‐condition animals. Black‐ and red‐coloured animals are more significantly affected by trypanosomosis than white‐coloured animals. Multivariable logistic regression revealed more about contributory factors than univariable logistic regression.
Solomon Mekuria, Aschenaki Kalsa
wiley   +1 more source

In Silico Investigation of TATA-Binding Protein as a Therapeutic Target for Chagas Disease: Insights into FDA Drug Repositioning

Pharmaceuticals
Background: Parasitic diseases, particularly Chagas disease caused by Trypanosoma cruzi, primarily affect developing countries but are now spreading to wealthier nations due to changing migration patterns. With approximately 8 to 9 million cases annually
Carlos Gaona-López, Domingo Méndez-Álvarez, Alonzo Gonzalez-Gonzalez, Guadalupe Avalos-Navarro, Alma D. Paz-González, Adriana Moreno-Rodríguez, Benjamín Nogueda-Torres, Gildardo Rivera   +7 more
doaj   +1 more source