Results 101 to 110 of about 3,959 (186)

Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease

Frontiers in Pharmacology, 2019
Leishmaniasis and Chagas disease cause great impact on social and economic aspects of people living in developing countries. The treatments for these diseases are based on the same regimen for over 40 years, thus, there is an urgent need for the ...
Roberval Nascimento Moraes Neto, Ruth Flávia Barros Setúbal, Taciana Mirely Maciel Higino, Maria Carolina Accioly Brelaz-de-Castro, Luís Cláudio Nascimento da Silva, Amanda Silva dos Santos Aliança   +5 more
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2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities [PDF]

, 2014
Artículo de publicacion ISIA series of new 2-aminonaphthoquinones and related compounds were synthesized and evaluated in vitro as trypanocidal and cytotoxic agents.
Villena, Juan, Quiñones, Natalia, Maya Arango, Juan, Salas, Cristian, Sieveking, Ivan, Estévez, Ramón J., Cassels Niven, Bruce, Thomas, Pablo, Estévez, Juan C., López Muñoz, Rodrigo, Tapia, Ricardo A., Cuéllar, Mauricio A., Espinosa Bustos, Christian, Fierro, Angélica   +13 more
core  

[Introduction of changes in the DNA of Trypanosoma cruzi by trypanocidal agents].

Revista Argentina de microbiologia, 1989
Incubation of Trypanosoma cruzi culture (epimastigote) forms with nifurtimox (10 or 100 microM), benznidazole (38 or 380 microM) and beta-lapachone (1.6 or 7.8 microM) produced damage of nuclear DNA, as shown by the increased rate of the "unscheduled DNA synthesis" in epimastigotes arrested at phase S (9-, 3-, and 6-fold, respectively). alpha-lapachone,
S G, Goijman, A C, Frasch, A O, Stoppani
openaire   +1 more source

The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz, 2010
Trypanosoma cruzi is a parasite that causes Chagas disease, which affects millions of individuals in endemic areas of Latin America. One hundred years after the discovery of Chagas disease, it is still considered a neglected illness because the available
Cristiane França da Silva, Patrícia Bernadino da Silva, Marcos Meuser Batista, Anissa Daliry, Richard R Tidwell, Maria de Nazaré Correia Soeiro   +5 more
doaj   +1 more source

Discovery of Novel Active Diamidines as Clinical Candidates Against "Trypanosoma Evansi" Infection [PDF]

, 2007
The animal pathogenic protozoan, Trypanosoma evansi, leads to a wasting disease in equines, cattle and camels, commonly known as Surra. It is extensively distributed geographically with a wide range of mammalian hosts and causes great economical loss ...
Gillingwater, Kirsten
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Synthesis of Novel Acetamidobenzanilides Derivatives as Potencial Trypanocidal Agents

Abstract A simple synthesis of novel N-(2-[N’-acetamidomethyl])benzanilides derivatives from 2-nitrobenzaldehyde in a four steps process is described. The 1H-NMR and 13C-NMR spectra were meticulously analyzed to characterize their structure and it was observed that derivatives with an ortho-substituted phenyl group exhibited detectable ...
Valentín I. Ortellado, Carlos U. Molfesa Kaczoruk, Lucio A. Guaymas, Emmanuele Parisi, Guido G. Fraga, Gisela C. Muscia, Fernanda M. Frank, Ana M. Bruno, Agustı́n Ponzinibbio, Leandro D. Sasiambarrena   +9 more
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Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and Trypanosoma cruzi Amastigotes

Pharmaceuticals
Background: Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both ...
Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca , Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima   +18 more
doaj   +1 more source

The trypanocidal effect of NO-releasing agents is not due to inhibition of the major cysteine proteinase in Trypanosoma brucei

, 2009
The lysosomal cysteine proteinase activity of bloodstream forms of Trypanosoma brucei is a validated drug target. Previously, it was reported that nitric oxide (NO)-releasing agents inhibit the catalytic activity of cysteine proteinases of the protozoan ...
Steverding, Dietmar, Wang, Xia, Sexton, Darren W.   +2 more
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The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process.

PLoS ONE, 2015
Chagas' disease is an infection that is caused by the protozoan Trypanosoma cruzi, affecting millions of people worldwide. Because of severe side effects and variable efficacy, the current treatments for Chagas' disease are unsatisfactory, making the ...
Vânia Cristina Desoti, Danielle Lazarin-Bidóia, Fabianne Martins Ribeiro, Solange Cardoso Martins, Jean Henrique da Silva Rodrigues, Tania Ueda-Nakamura, Celso Vataru Nakamura, Valdecir Farias Ximenes, Sueli de Oliveira Silva   +8 more
doaj   +1 more source

Evaluating 5-nitrothiazoles as trypanocidal agents

, 2013
s.r.wilkinson@qmul.ac ...
Bot, Christopher, Hall, Belinda S., Alvarez, Guzman, Di Maio, Rossanna, Gonzalez, Mercedes, Cerecetto, Hugo, Wilkinson, Shane R.   +6 more
openaire   +2 more sources