Results 121 to 130 of about 3,959 (186)

Obtenção de moléculas bioativas a partir de substâncias naturais e sintéticas [PDF]

, 2005
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em QuímicaO trabalho envolveu a síntese e avaliação da atividade farmacológica de análogos de produtos naturais, incluindo ...
Boeck, Paula
core  

Psilostachyin C: a natural compound with trypanocidal activity

, 2011
Item does not contain fulltextIn this study, the antiprotozoal activity of the sesquiterpene lactone psilostachyin C was investigated. This natural compound was isolated from Ambrosia scabra by bioassay-guided fractionation and was identified by ...
Sulsen, V.P., Sülsen, Valeria Patricia, Martino, V.S., Roser Vila, Virginia S. Martino, Frank, Fernanda María, Vila, R., Freixa, Blanca, Emilio L. Malchiodi, Sosa, M.A., Patricia Barrera, Cazorla, Silvia Ines, Freixa, B., Miguel A. Sosa, Muschietti, Liliana Victoria, Malchiodi, Emilio Luis, Sosa Escudero, Miguel Angel, Martino, Virginia Susana, Valeria P. Sülsen, Cazorla, S.I., Barrera, Patricia Andrea, Silvia I. Cazorla, Blanca Freixa, Vila, Roser, Frank, F.M., Muschietti, L.V., Liliana V. Muschietti, Barrera, P., Malchiodi, E.L., Fernanda M. Frank   +29 more
core   +1 more source

Natural and Bioinspired Lipidic Alkynylcarbinols as Leishmanicidal, Antiplasmodial, Trypanocidal, Fungicidal, Antibacterial, and Antimycobacterial Agents

Journal of Natural Products
The present review article recapitulates for the first time the antipathogenic biological data of a series of lipidic natural products and synthetic analogues thereof characterized by the presence in their structure of an alkynylcarbinol unit. The cytotoxic properties of such natural and bioinspired compounds have been covered by several literature ...
Bouvet, Jon, Maraval, Valérie, Ballereau, Stéphanie, Bernardes-Génisson, Vania, Génisson, Yves   +4 more
openaire   +2 more sources

Topoisomerase-II mediated biochemical mapping of centromeres and nitroreductase mediated drug metabolism in Trypanosomatids

, 2012
PhDThe protozoan parasites Trypanosoma cruzi and Trypanosoma brucei are the causative agents of Chagas disease and Human African sleeping sickness respectively.
Bot, Christopher
core  

Tris(3-methoxypropyl)tin aminobenzoates as potentially trypanocidal agent

, 2004
A set of tris(3-methoxypropyl)tin aminobenzoates and N-(4,6-diamino-1,3,5-triazin-2-yl-)aminobenzoates as compounds with potential trypanocidal activity have been prepared and their solubility in water was determined. On the basis of their 13C and 119Sn NMR spectra and IR spectra, bonding relations in these esters are discussed and a model of the ...
Semenyšínová, Lenka, Handlíř, Karel
openaire   +1 more source

New Lipophilic Hydroxamates as Promising Trypanocidal Agents: Design, Synthesis, SAR, and Conformational Behavior Studies. [PDF]

ACS Med Chem Lett
Fytas G, Zoidis G, Drakopoulos A, Taylor MC, Kelly JM, Tsatsaroni A, Tsotinis A.   +6 more
europepmc   +1 more source

Value of the Run-In Period to Evaluate the Safety of Conventional Trypanocidal Treatment: A Subanalysis of a Colombian Randomized Clinical Trial. [PDF]

Am J Trop Med Hyg
Villar JC, Arango H, Sáenz-Pérez LD, Camacho A.   +3 more
europepmc   +1 more source

Using the Scaffold of FDA-Approved Drugs with Trypanocidal Activity to Identify New Anti-<i>Trypanosoma cruzi</i> Agents: An In Silico and In Vitro Approach. [PDF]

Molecules
Vázquez-Jiménez LK, González-González A, Delgado-Maldonado T, Gómez-Escobedo R, Avalos-Navarro G, Moreno-Rodríguez A, Paz-González AD, Ortiz-Pérez E, Nogueda-Torres B, Rivera G.   +9 more
europepmc   +1 more source

Protocol of a mixed (Retrospective and Prospective) longitudinal observational study of amiodarone for chronic Chagas cardiomyopathy (AMIO-CHAGAS study): Investigating immunomodulatory and trypanocidal effects. [PDF]

PLoS One
Barbosa JMC, Faier-Pereira A, Hasslocher-Moreno AM, Costa AR, Pereira ENGDS, Mendes FSNS, da Silva GMS, Sangenis LHC, Holanda MT, Mediano MFF, Saraiva RM, Xavier SS, Moreira ODC, Daliry A, Veloso HH, Salomão K.   +15 more
europepmc   +1 more source

Chagas disease and amiodarone: a bibliometric and systematic review from cell to patient. [PDF]

Front Pharmacol
Barbosa JMC, Duarte RB, Veloso HH, Daliry A, Salomão K.   +4 more
europepmc   +1 more source