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Computational drug repositioning with attention walking [PDF]

Scientific Reports
Drug repositioning aims to identify new therapeutic indications for approved medications. Recently, the importance of computational drug repositioning has been highlighted because it can reduce the costs, development time, and risks compared to ...
Jong-Hoon Park, Young-Rae Cho
doaj   +4 more sources

Some Aspects and Convergence of Human and Veterinary Drug Repositioning [PDF]

Molecules
Drug innovation traditionally follows a de novo approach with new molecules through a complex preclinical and clinical pathway. In addition to this strategy, drug repositioning has also become an important complementary approach, which can be shorter ...
Patrik Mag, Melinda Nemes-Terényi, Ákos Jerzsele, Péter Mátyus   +3 more
doaj   +2 more sources

Large Language Model–Enhanced Drug Repositioning Knowledge Extraction via Long Chain-of-Thought: Development and Evaluation Study

JMIR Medical Informatics
BackgroundDrug repositioning is a pivotal strategy in pharmaceutical research, offering accelerated and cost-effective therapeutic discovery. However, biomedical information relevant to drug repositioning is often complex, dispersed, and underutilized ...
Hongyu Kang, Jiao Li, Li Hou, Xiaowei Xu, Si Zheng, Qin Li   +5 more
doaj   +2 more sources

A Study on Methodologies of Drug Repositioning Using Biomedical Big Data: A Focus on Diabetes Mellitus [PDF]

Endocrinology and Metabolism, 2022
Drug repositioning is a strategy for identifying new applications of an existing drug that has been previously proven to be safe. Based on several examples of drug repositioning, we aimed to determine the methodologies and relevant steps associated with ...
Suehyun Lee, Seongwoo Jeon, Hun-Sung Kim
doaj   +1 more source

From In Silico Hypothesis to Validation: The Role of Real-World Evidence in the Preliminary Verification of AI-Generated Drug-Repositioning Candidates: A Comprehensive Review. [PDF]

J Clin Med
Gałuszewski M, Olszewski J, Jankowska K, Wójcik K, Bielecka-Wajdman A.   +4 more
europepmc   +3 more sources

Analgesic Effect of SH003 and Trichosanthes kirilowii Maximowicz in Paclitaxel-Induced Neuropathic Pain in Mice

Current Issues in Molecular Biology, 2022
Pacliatxel is a taxol-based chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Ji Hwan Lee, Bonglee Kim, Seong-Gyu Ko, Woojin Kim   +3 more
doaj   +1 more source

MVSGDR: multi-view stacked graph convolutional network for drug repositioning. [PDF]

Brief Bioinform
Gu G, Wu H, Han H, Lin Z, Sun Y, Xie G, Su Q, Liu Z.   +7 more
europepmc   +3 more sources

Effect and Mechanism of Herbal Medicines on Cisplatin-Induced Anorexia

Pharmaceuticals, 2022
Cisplatin is a well-known chemotherapeutic agent used to treat various types of cancers; however, it can also induce anorexia, which results in reduced food intake, loss of body weight, and lower quality of life.
Daeun Min, Bonglee Kim, Seong-Gyu Ko, Woojin Kim   +3 more
doaj   +1 more source

Daemonorops draco Blume Induces Apoptosis Against Acute Myeloid Leukemia Cells via Regulation of the miR-216b/c-Jun

Frontiers in Oncology, 2022
Daemonorops draco Blume (DD), also called dragon’s blood, has been used as a traditional Korean medicine, especially for relieving pain caused by wound infection. Recently, it has been described that DD has antibacterial and analgesic effects.
Moon Nyeo Park, Moon Nyeo Park, Hee Won Jeon, Md. Ataur Rahman, Md. Ataur Rahman, Se Sun Park, Se Yun Jeong, Ki Hyun Kim, Sung-Hoon Kim, Woojin Kim, Bonglee Kim, Bonglee Kim   +11 more
doaj   +1 more source

Drug Repositioning Using Temporal Trajectories of Accompanying Comorbidities in Diabetes Mellitus [PDF]

Endocrinology and Metabolism, 2022
Background Most studies of systematic drug repositioning have used drug-oriented data such as chemical structures, gene expression patterns, and adverse effect profiles.
Namgi Park, Ja Young Jeon, Eugene Jeong, Soyeon Kim, Dukyong Yoon   +4 more
doaj   +1 more source