Results 1 to 10 of about 25,894 (252)
Computational and Structural Biotechnology Journal, 2020 Drug repositioning aims to find new indications for existing drugs in order to reduce drug development cost and time. Currently,there are numerous stories of successful drug repositioning that have been reported and many repurposed drugs are already ...
Daniele Parisi +5 more
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Viruses, 2020 Traditionally, drug discovery utilises a de novo design approach, which requires high cost and many years of drug development before it reaches the market.
Zheng Yao Low +2 more
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Computational Drug Repositioning: Current Progress and Challenges
Applied Sciences, 2020 Novel drug discovery is time-consuming, costly, and a high-investment process due to the high attrition rate. Therefore, many trials are conducted to reuse existing drugs to treat pressing conditions and diseases, since their safety profiles and ...
Younhee Ko
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Some Aspects and Convergence of Human and Veterinary Drug Repositioning [PDF]
MoleculesDrug innovation traditionally follows a de novo approach with new molecules through a complex preclinical and clinical pathway. In addition to this strategy, drug repositioning has also become an important complementary approach, which can be shorter ...
Patrik Mag +3 more
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DMAPLM: A multimodal pretrained framework for computational drug repositioning. [PDF]
PLoS Computational BiologyDrug repositioning offers an efficient route to discover new therapeutic indications for existing drugs. However, current computational drug repositioning models often face challenges related to data scarcity, heterogeneity, and therefore limited ...
Hailin Chen, Zhongling Li
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Large Language Model–Enhanced Drug Repositioning Knowledge Extraction via Long Chain-of-Thought: Development and Evaluation Study [PDF]
JMIR Medical InformaticsBackgroundDrug repositioning is a pivotal strategy in pharmaceutical research, offering accelerated and cost-effective therapeutic discovery. However, biomedical information relevant to drug repositioning is often complex, dispersed, and underutilized ...
Hongyu Kang +5 more
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A Study on Methodologies of Drug Repositioning Using Biomedical Big Data: A Focus on Diabetes Mellitus [PDF]
Endocrinology and Metabolism, 2022 Drug repositioning is a strategy for identifying new applications of an existing drug that has been previously proven to be safe. Based on several examples of drug repositioning, we aimed to determine the methodologies and relevant steps associated with ...
Suehyun Lee, Seongwoo Jeon, Hun-Sung Kim
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Current Issues in Molecular Biology, 2022 Pacliatxel is a taxol-based chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Ji Hwan Lee +3 more
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Effect and Mechanism of Herbal Medicines on Cisplatin-Induced Anorexia
Pharmaceuticals, 2022 Cisplatin is a well-known chemotherapeutic agent used to treat various types of cancers; however, it can also induce anorexia, which results in reduced food intake, loss of body weight, and lower quality of life.
Daeun Min +3 more
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Frontiers in Oncology, 2022 Daemonorops draco Blume (DD), also called dragon’s blood, has been used as a traditional Korean medicine, especially for relieving pain caused by wound infection. Recently, it has been described that DD has antibacterial and analgesic effects.
Moon Nyeo Park +11 more
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