Results 41 to 50 of about 1,821,409 (281)

Enriching limited information on rare diseases from heterogeneous networks for drug repositioning

BMC Medical Informatics and Decision Making, 2021
Background The historical data of rare disease is very scarce in reality, so how to perform drug repositioning for the rare disease is a great challenge.
Hongkui Cao, Liang Zhang, Bo Jin, Shicheng Cheng, Xiaopeng Wei, Chao Che   +5 more
doaj   +1 more source

Drug repositioning based on network-specific core genes identifies potential drugs for the treatment of autism spectrum disorder in children

Computational and Structural Biotechnology Journal, 2021
Identification of exact causative genes is important for in silico drug repositioning based on drug-gene-disease relationships. However, the complex polygenic etiology of the autism spectrum disorder (ASD) is a challenge in the identification of ...
Huan Gao, Yuan Ni, Xueying Mo, Dantong Li, Shan Teng, Qingsheng Huang, Shuai Huang, Guangjian Liu, Sheng Zhang, Yaping Tang, Long Lu, Huiying Liang   +11 more
doaj   +1 more source

A standard database for drug repositioning [PDF]

Scientific Data, 2017
AbstractDrug repositioning, the process of discovering, validating, and marketing previously approved drugs for new indications, is of growing interest to academia and industry due to reduced time and costs associated with repositioned drugs. Computational methods for repositioning are appealing because they putatively nominate the most promising ...
Brown, Adam S., Patel, Chirag J.
openaire   +4 more sources

Integration of various protein similarities using random forest technique to infer augmented drug-protein matrix for enhancing drug-disease association prediction

Science Progress, 2022
Identifying new therapeutic indications for existing drugs is a major challenge in drug repositioning. Most computational drug repositioning methods focus on known targets.
Satanat Kitsiranuwat, Apichat Suratanee, Kitiporn Plaimas   +2 more
doaj   +1 more source

DrugSig: A resource for computational drug repositioning utilizing gene expression signatures. [PDF]

PLoS ONE, 2017
Computational drug repositioning has been proved as an effective approach to develop new drug uses. However, currently existing strategies strongly rely on drug response gene signatures which scattered in separated or individual experimental data, and ...
Hongyu Wu, Jinjiang Huang, Yang Zhong, Qingshan Huang   +3 more
doaj   +1 more source

Drug Repositioning for Hand, Foot, and Mouth Disease

Viruses, 2022
Hand, foot, and mouth disease (HFMD) is a highly contagious disease in children caused by a group of enteroviruses. HFMD currently presents a major threat to infants and young children because of a lack of antiviral drugs in clinical practice.
Ran Yan, Jiahao He, Ge Liu, Jianfeng Zhong, Jiapeng Xu, Kai Zheng, Zhe Ren, Zhendan He, Qinchang Zhu   +8 more
doaj   +1 more source

Network Pharmacology for Drug Repositioning in Anti-Alzheimer’s Drug Development

, 2023
Alzheimer’s disease (AD) has become a public health emergency due to its complexity and heterogeneity; therefore, therapeutic regimens must focus on cure rather than symptom management.
Mitra, S., Dash, N., Munni, Yeasmin Akter, Moon, I.S., Dash, Raju   +4 more
core   +1 more source

Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate [PDF]

BackgroundDrug repurposing or repositioning refers to the usage of existing drugs in diseases other than those it was originally used for. For diseases like malaria, where there is an urgent need for active drug candidates, the strategy offers a route to
Usman-Idris, M, Matthews, H, Khan, F, Read, M, Nirmalan, NJ   +4 more
core   +1 more source

Drug-repositioning signals validated by gene expression analysis.

, 2018
Drug-repositioning signals validated by gene expression analysis.
Mitsutaka Takada (5832344), Mai Fujimoto (5832338), Lili Mao (289583), Kouichi Hosomi (5832335), Kazutaka Ushio (5832341), Juran Kato (2093692)   +5 more
core   +1 more source

Benchmarking algorithms for computational drug repositioning

, 2023
This repository contains all the datasets used for benchmarking drug repositioning methods, including drug-drug similarity, disease-disease similarity, and drug-disease associations.
yinqi yang, yinghong li
core   +1 more source