Results 41 to 50 of about 25,687 (255)

RepCOOL: computational drug repositioning via integrating heterogeneous biological networks

Journal of Translational Medicine, 2020
Background It often takes more than 10 years and costs more than 1 billion dollars to develop a new drug for a particular disease and bring it to the market. Drug repositioning can significantly reduce costs and time in drug development.
Ghazale Fahimian, Javad Zahiri, Seyed Shahriar Arab, Reza H. Sajedi   +3 more
doaj   +1 more source

In silico drug repositioning based on the integration of chemical, genomic and pharmacological spaces

BMC Bioinformatics, 2021
Background Drug repositioning refers to the identification of new indications for existing drugs. Drug-based inference methods for drug repositioning apply some unique features of drugs for new indication prediction. Complementary information is provided
Hailin Chen, Zuping Zhang, Jingpu Zhang
doaj   +1 more source

Repositioning Natural Products in Drug Discovery [PDF]

Molecules, 2020
Drug repositioning (o repurposing) has become one of the most popular and successful strategies to reduce failures typically associated with drug discovery [...]
Rastelli, G., Pellati, F., Pinzi, L., Gamberini, M. C.   +3 more
openaire   +4 more sources

Maltol has anti-cancer effects via modulating PD-L1 signaling pathway in B16F10 cells

Frontiers in Pharmacology, 2023
Introduction: Among skin cancers, melanoma has a high mortality rate. Recent advances in immunotherapy, particularly through immune checkpoint modulation, have improved the clinical treatment of melanoma.
Na-Ra Han, Na-Ra Han, Hi-Joon Park, Seong-Gyu Ko, Seong-Gyu Ko, Phil-Dong Moon   +5 more
doaj   +1 more source

Enriching limited information on rare diseases from heterogeneous networks for drug repositioning

BMC Medical Informatics and Decision Making, 2021
Background The historical data of rare disease is very scarce in reality, so how to perform drug repositioning for the rare disease is a great challenge.
Hongkui Cao, Liang Zhang, Bo Jin, Shicheng Cheng, Xiaopeng Wei, Chao Che   +5 more
doaj   +1 more source

Integration of various protein similarities using random forest technique to infer augmented drug-protein matrix for enhancing drug-disease association prediction

Science Progress, 2022
Identifying new therapeutic indications for existing drugs is a major challenge in drug repositioning. Most computational drug repositioning methods focus on known targets.
Satanat Kitsiranuwat, Apichat Suratanee, Kitiporn Plaimas   +2 more
doaj   +1 more source

Drug repositioning based on network-specific core genes identifies potential drugs for the treatment of autism spectrum disorder in children

Computational and Structural Biotechnology Journal, 2021
Identification of exact causative genes is important for in silico drug repositioning based on drug-gene-disease relationships. However, the complex polygenic etiology of the autism spectrum disorder (ASD) is a challenge in the identification of ...
Huan Gao, Yuan Ni, Xueying Mo, Dantong Li, Shan Teng, Qingsheng Huang, Shuai Huang, Guangjian Liu, Sheng Zhang, Yaping Tang, Long Lu, Huiying Liang   +11 more
doaj   +1 more source

Repositioning of Antiparasitic Drugs for Tumor Treatment [PDF]

Frontiers in Oncology, 2021
Drug repositioning is a strategy for identifying new antitumor drugs; this strategy allows existing and approved clinical drugs to be innovatively repurposed to treat tumors. Based on the similarities between parasitic diseases and cancer, recent studies aimed to investigate the efficacy of existing antiparasitic drugs in cancer.
Yan-Qi Li, Zhi Zheng, Quan-Xing Liu, Xiao Lu, Dong Zhou, Jiao Zhang, Hong Zheng, Ji-Gang Dai   +7 more
openaire   +3 more sources

Drug Repositioning for Hand, Foot, and Mouth Disease

Viruses, 2022
Hand, foot, and mouth disease (HFMD) is a highly contagious disease in children caused by a group of enteroviruses. HFMD currently presents a major threat to infants and young children because of a lack of antiviral drugs in clinical practice.
Ran Yan, Jiahao He, Ge Liu, Jianfeng Zhong, Jiapeng Xu, Kai Zheng, Zhe Ren, Zhendan He, Qinchang Zhu   +8 more
doaj   +1 more source

DrugSig: A resource for computational drug repositioning utilizing gene expression signatures. [PDF]

PLoS ONE, 2017
Computational drug repositioning has been proved as an effective approach to develop new drug uses. However, currently existing strategies strongly rely on drug response gene signatures which scattered in separated or individual experimental data, and ...
Hongyu Wu, Jinjiang Huang, Yang Zhong, Qingshan Huang   +3 more
doaj   +1 more source