Results 41 to 50 of about 60,427 (345)

Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. [PDF]

, 2013
Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions.
Chen, Thomas C, Gonzalez, Reyna, Hofman, Florence M, Louie, Stan G, Pao, Peng-Wen, Pirrung, Michael C, Schönthal, Axel H, Sharma, Natasha, Thomas, Simmy   +8 more
core   +2 more sources

Drug repositioning for orphan diseases [PDF]

Briefings in Bioinformatics, 2011
The need and opportunity to discover therapeutics for rare or orphan diseases are enormous. Due to limited prevalence and/or commercial potential, of the approximately 6000 orphan diseases (defined by the FDA Orphan Drug Act as
Divya, Sardana, Cheng, Zhu, Minlu, Zhang, Ranga C, Gudivada, Lun, Yang, Anil G, Jegga   +5 more
openaire   +2 more sources

Computational Drug Repositioning: Current Progress and Challenges

Applied Sciences, 2020
Novel drug discovery is time-consuming, costly, and a high-investment process due to the high attrition rate. Therefore, many trials are conducted to reuse existing drugs to treat pressing conditions and diseases, since their safety profiles and ...
Younhee Ko
doaj   +1 more source

Maltol has anti-cancer effects via modulating PD-L1 signaling pathway in B16F10 cells

Frontiers in Pharmacology, 2023
Introduction: Among skin cancers, melanoma has a high mortality rate. Recent advances in immunotherapy, particularly through immune checkpoint modulation, have improved the clinical treatment of melanoma.
Na-Ra Han, Na-Ra Han, Hi-Joon Park, Seong-Gyu Ko, Seong-Gyu Ko, Phil-Dong Moon   +5 more
doaj   +1 more source

DHLP 1&2: Giraph based distributed label propagation algorithms on heterogeneous drug-related networks

, 2020
Background and Objective: Heterogeneous complex networks are large graphs consisting of different types of nodes and edges. The knowledge extraction from these networks is complicated. Moreover, the scale of these networks is steadily increasing.
Ghadiri, Nasser, Maleki, Erfan Farhangi, Maleki, Zeinab, Shahreza, Maryam Lotfi   +3 more
core   +1 more source

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

Enriching limited information on rare diseases from heterogeneous networks for drug repositioning

BMC Medical Informatics and Decision Making, 2021
Background The historical data of rare disease is very scarce in reality, so how to perform drug repositioning for the rare disease is a great challenge.
Hongkui Cao, Liang Zhang, Bo Jin, Shicheng Cheng, Xiaopeng Wei, Chao Che   +5 more
doaj   +1 more source

Drug repositioning based on network-specific core genes identifies potential drugs for the treatment of autism spectrum disorder in children

Computational and Structural Biotechnology Journal, 2021
Identification of exact causative genes is important for in silico drug repositioning based on drug-gene-disease relationships. However, the complex polygenic etiology of the autism spectrum disorder (ASD) is a challenge in the identification of ...
Huan Gao, Yuan Ni, Xueying Mo, Dantong Li, Shan Teng, Qingsheng Huang, Shuai Huang, Guangjian Liu, Sheng Zhang, Yaping Tang, Long Lu, Huiying Liang   +11 more
doaj   +1 more source

Herb Target Prediction Based on Representation Learning of Symptom related Heterogeneous Network. [PDF]

, 2019
Traditional Chinese Medicine (TCM) has received increasing attention as a complementary approach or alternative to modern medicine. However, experimental methods for identifying novel targets of TCM herbs heavily relied on the current available herb ...
Chen, Jianxin, Gao, Zhuye, Hu, Xiaochen, Li, Peng, Liu, Baoyan, Peng, Yonghong, Wang, Ning, Xu, Hao, Yang, Kuo, Zhang, Runshun, Zhou, Xuezhong, Zhu, Qiang   +11 more
core   +1 more source

Integration of various protein similarities using random forest technique to infer augmented drug-protein matrix for enhancing drug-disease association prediction

Science Progress, 2022
Identifying new therapeutic indications for existing drugs is a major challenge in drug repositioning. Most computational drug repositioning methods focus on known targets.
Satanat Kitsiranuwat, Apichat Suratanee, Kitiporn Plaimas   +2 more
doaj   +1 more source