Results 41 to 50 of about 1,936,479 (187)

Maltol has anti-cancer effects via modulating PD-L1 signaling pathway in B16F10 cells

Frontiers in Pharmacology, 2023
Introduction: Among skin cancers, melanoma has a high mortality rate. Recent advances in immunotherapy, particularly through immune checkpoint modulation, have improved the clinical treatment of melanoma.
Na-Ra Han, Na-Ra Han, Hi-Joon Park, Seong-Gyu Ko, Seong-Gyu Ko, Phil-Dong Moon   +5 more
doaj   +1 more source

Enriching limited information on rare diseases from heterogeneous networks for drug repositioning

BMC Medical Informatics and Decision Making, 2021
Background The historical data of rare disease is very scarce in reality, so how to perform drug repositioning for the rare disease is a great challenge.
Hongkui Cao, Liang Zhang, Bo Jin, Shicheng Cheng, Xiaopeng Wei, Chao Che   +5 more
doaj   +1 more source

Integration of various protein similarities using random forest technique to infer augmented drug-protein matrix for enhancing drug-disease association prediction

Science Progress, 2022
Identifying new therapeutic indications for existing drugs is a major challenge in drug repositioning. Most computational drug repositioning methods focus on known targets.
Satanat Kitsiranuwat, Apichat Suratanee, Kitiporn Plaimas   +2 more
doaj   +1 more source

Drug repositioning based on network-specific core genes identifies potential drugs for the treatment of autism spectrum disorder in children

Computational and Structural Biotechnology Journal, 2021
Identification of exact causative genes is important for in silico drug repositioning based on drug-gene-disease relationships. However, the complex polygenic etiology of the autism spectrum disorder (ASD) is a challenge in the identification of ...
Huan Gao, Yuan Ni, Xueying Mo, Dantong Li, Shan Teng, Qingsheng Huang, Shuai Huang, Guangjian Liu, Sheng Zhang, Yaping Tang, Long Lu, Huiying Liang   +11 more
doaj   +1 more source

A standard database for drug repositioning [PDF]

Scientific Data, 2017
AbstractDrug repositioning, the process of discovering, validating, and marketing previously approved drugs for new indications, is of growing interest to academia and industry due to reduced time and costs associated with repositioned drugs. Computational methods for repositioning are appealing because they putatively nominate the most promising ...
Brown, Adam S., Patel, Chirag J.
openaire   +4 more sources

Drug Repositioning: Current Advances and Future Perspectives [PDF]

, 2019
Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can
Yuhei Nishimura, Hideaki Hara
core   +1 more source

DrugSig: A resource for computational drug repositioning utilizing gene expression signatures. [PDF]

PLoS ONE, 2017
Computational drug repositioning has been proved as an effective approach to develop new drug uses. However, currently existing strategies strongly rely on drug response gene signatures which scattered in separated or individual experimental data, and ...
Hongyu Wu, Jinjiang Huang, Yang Zhong, Qingshan Huang   +3 more
doaj   +1 more source

Drug Repositioning for Hand, Foot, and Mouth Disease

Viruses, 2022
Hand, foot, and mouth disease (HFMD) is a highly contagious disease in children caused by a group of enteroviruses. HFMD currently presents a major threat to infants and young children because of a lack of antiviral drugs in clinical practice.
Ran Yan, Jiahao He, Ge Liu, Jianfeng Zhong, Jiapeng Xu, Kai Zheng, Zhe Ren, Zhendan He, Qinchang Zhu   +8 more
doaj   +1 more source

Drug-repositioning signals validated by gene expression analysis.

, 2018
Drug-repositioning signals validated by gene expression analysis.
Mitsutaka Takada (5832344), Mai Fujimoto (5832338), Lili Mao (289583), Kouichi Hosomi (5832335), Kazutaka Ushio (5832341), Juran Kato (2093692)   +5 more
core   +1 more source

Summary of drug-repositioning signals.

, 2018
Summary of drug-repositioning signals.
Mitsutaka Takada (5832344), Mai Fujimoto (5832338), Lili Mao (289583), Kouichi Hosomi (5832335), Kazutaka Ushio (5832341), Juran Kato (2093692)   +5 more
core   +1 more source