Results 61 to 70 of about 60,427 (345)

Turning genome-wide association study findings into opportunities for drug repositioning

Computational and Structural Biotechnology Journal, 2020
Drug development is a very costly and lengthy process, while repositioned or repurposed drugs could be brought into clinical practice within a shorter time-frame and at a much reduced cost.
Alexandria Lau, Hon-Cheong So
doaj   +1 more source

Predicting Drug–Gene–Disease Associations by Tensor Decomposition for Network-Based Computational Drug Repositioning

Biomedicines, 2023
Drug repositioning offers the significant advantage of greatly reducing the cost and time of drug discovery by identifying new therapeutic indications for existing drugs.
Yoonbee Kim, Young-Rae Cho
doaj   +1 more source

A neuronal network of mitochondrial dynamics regulates metastasis. [PDF]

, 2016
The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize
Aguinaldo, Angeline, Altieri, Dario C., Bosari, Silvano, Bryant, Kelly G., Caino, M. Cecilia, Cohen, Andrew R., Ferrero, Stefano, Gabrilovich, Dmitry I., Hayden, James E., Kossenkov, Andrew V., Languino, Lucia R., Morotti, Annamaria, Seo, Jae Ho, Vaira, Valentina, Wait, Eric   +14 more
core   +3 more sources

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Drug repositioning based on heterogeneous networks and variational graph autoencoders

Frontiers in Pharmacology, 2022
Predicting new therapeutic effects (drug repositioning) of existing drugs plays an important role in drug development. However, traditional wet experimental prediction methods are usually time-consuming and costly.
Song Lei, Xiujuan Lei, Lian Liu
doaj   +1 more source

Schistosomes and snails: A molecular encounter [PDF]

, 2014
Copyright © 2014 Knight, Arican-Goktas, Ittiprasert, Odoemelam, Miller and Bridger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Arican-Goktas, HD, Bridger, JM, Ittiprasert, W, Knight, M, Miller, AN, Odoemelam, EC   +5 more
core   +3 more sources

High‐Resolution and Real‐Time In Situ Generation of Cellular Spheroids by Laser‐Assisted Bioprinting for Guided Microvascularization

Advanced Functional Materials, EarlyView.
Micro‐injection laser‐assisted bioprinting enables ultrafast and precise patterning of small endothelial cell spheroids by injecting a highly concentrated single‐cell suspension into GelMA/ColMA hydrogels. In co‐culture with fibroblasts, controlled pre‐vasculogenic network formation is obtained at microscale resolution.
Charles Handschin, Katharina Wulz, Clotilde Jugie, Marie‐Laure Stachowicz, Shane Fennell, Aurélien Mazet, Malou Lea, Nathalie Dusserre, Jean‐Christophe Fricain, Hugo Oliveira   +9 more
wiley   +1 more source

Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer

The Scientific World Journal, 2015
The goals of drug repositioning are to find a new pharmacological effect of a drug for which human safety and pharmacokinetics are established and to expand the therapeutic range of the drug to another disease. Such drug discovery can be performed at low
Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki   +7 more
doaj   +1 more source

DrugMechDB: A Curated Database of Drug Mechanisms

Scientific Data, 2023
Computational drug repositioning methods have emerged as an attractive and effective solution to find new candidates for existing therapies, reducing the time and cost of drug development.
Adriana Carolina Gonzalez-Cavazos, Anna Tanska, Michael Mayers, Denise Carvalho-Silva, Brindha Sridharan, Patrick A. Rewers, Umasri Sankarlal, Lakshmanan Jagannathan, Andrew I. Su   +8 more
doaj   +1 more source