Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate [PDF]
BackgroundDrug repurposing or repositioning refers to the usage of existing drugs in diseases other than those it was originally used for. For diseases like malaria, where there is an urgent need for active drug candidates, the strategy offers a route to
Usman-Idris, M +4 more
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Turning genome-wide association study findings into opportunities for drug repositioning
Computational and Structural Biotechnology Journal, 2020 Drug development is a very costly and lengthy process, while repositioned or repurposed drugs could be brought into clinical practice within a shorter time-frame and at a much reduced cost.
Alexandria Lau, Hon-Cheong So
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Systems biology based drug repositioning for development of cancer therapy
, 2021 Drug repositioning is a powerful method that can assists the conventional drug discovery process by using existing drugs for treatment of a disease rather than its original indication.
ARĞA, KAZIM YALÇIN, TURANLI, BESTE
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Drug repositioning and repurposing for Alzheimer disease [PDF]
Nature Reviews Neurology, 2020 Drug repositioning and repurposing can enhance traditional drug development efforts and could accelerate the identification of new treatments for individuals with Alzheimer disease (AD) dementia and mild cognitive impairment. Transcriptional profiling offers a new and highly efficient approach to the identification of novel candidates for repositioning
Ballard, Clive +10 more
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Frontiers in Pharmacology, 2022 Gastric cancer (GC), second most leading cause of cancer-associated mortality globally, is the cancer of gastrointestinal tract in which malignant cells form in lining of the stomach, resulting in indigestion, pain, and stomach discomfort.
Md. Ataur Rahman +9 more
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Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer
The Scientific World Journal, 2015 The goals of drug repositioning are to find a new pharmacological effect of a drug for which human safety and pharmacokinetics are established and to expand the therapeutic range of the drug to another disease. Such drug discovery can be performed at low
Kouji Banno +7 more
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Integrative resource for network-based investigation of COVID-19 combinatorial drug repositioning and mechanism of action [PDF]
, 2021 An effective monotherapy to target the complex and multifactorial pathology of SARS-CoV-2 infection poses a challenge to drug repositioning, which can be improved by combination therapy.
A K M, Azad +19 more
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DrugMechDB: A Curated Database of Drug Mechanisms
Scientific Data, 2023 Computational drug repositioning methods have emerged as an attractive and effective solution to find new candidates for existing therapies, reducing the time and cost of drug development.
Adriana Carolina Gonzalez-Cavazos +8 more
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Drug repositioning based on heterogeneous networks and variational graph autoencoders
Frontiers in Pharmacology, 2022 Predicting new therapeutic effects (drug repositioning) of existing drugs plays an important role in drug development. However, traditional wet experimental prediction methods are usually time-consuming and costly.
Song Lei, Xiujuan Lei, Lian Liu
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Drug repositioning with adaptive graph convolutional networks
, 2023 Drug repositioning is an effective strategy to identify new indications for existing drugs, providing the quickest possible transition from bench to bedside.
Li, Min +4 more
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