Drug Repositioning for Hand, Foot, and Mouth Disease
Viruses, 2022 Hand, foot, and mouth disease (HFMD) is a highly contagious disease in children caused by a group of enteroviruses. HFMD currently presents a major threat to infants and young children because of a lack of antiviral drugs in clinical practice.
Ran Yan +8 more
doaj +1 more source
Drug combination therapy increases successful drug repositioning [PDF]
Drug Discovery Today, 2016 Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years.
Wei, Sun +2 more
openaire +2 more sources
DrugSig: A resource for computational drug repositioning utilizing gene expression signatures. [PDF]
PLoS ONE, 2017 Computational drug repositioning has been proved as an effective approach to develop new drug uses. However, currently existing strategies strongly rely on drug response gene signatures which scattered in separated or individual experimental data, and ...
Hongyu Wu +3 more
doaj +1 more source
Drug prescription support in dental clinics through drug corpus mining [PDF]
, 2018 The rapid increase in the volume and variety of data poses a challenge to safe drug prescription for the dentist. The increasing number of patients that take multiple drugs further exerts pressure on the dentist to make the right decision at point-of ...
Goh, Wee Pheng +5 more
core +5 more sources
Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]
, 2019 Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad +5 more
core +1 more source
Antiretroviral Drug Repositioning for Glioblastoma. [PDF]
Cancers (Basel)Outcomes for glioblastoma (GBM) remain poor despite standard-of-care treatments including surgical resection, radiation, and chemotherapy. Intratumoral heterogeneity contributes to treatment resistance and poor prognosis, thus demanding novel therapeutic approaches.
Rivas SR +16 more
europepmc +3 more sources
A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials [PDF]
, 2017 There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease.
Agresti, C. +11 more
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MeSHDD: Literature-based drug-drug similarity for drug repositioning [PDF]
Journal of the American Medical Informatics Association, 2016 Objective: Drug repositioning is a promising methodology for reducing the cost and duration of the drug discovery pipeline. We sought to develop a computational repositioning method leveraging annotations in the literature, such as Medical Subject Heading (MeSH) terms.
Brown, Adam, Patel, Chirag
openaire +3 more sources
Drug repositioning : a machine-learning approach through data integration [PDF]
, 2013 Existing computational methods for drug repositioning either rely only on the gene expression response of cell lines after treatment, or on drug-to-disease relationships, merging several information levels.
D'Amato, Mauro +6 more
core +1 more source
RESKO: Repositioning drugs by using side effects and knowledge from ontologies [PDF]
, 2018 The objective of drug repositioning is to apply existing drugs to different diseases or medical conditions than the original target, and thus alleviate to a certain extent the time and cost expended in drug development.
Graham, Yitka +3 more
core +1 more source