Results 31 to 40 of about 25,687 (255)
Drug repositioning: A bibliometric analysis
Frontiers in Pharmacology, 2022 Drug repurposing has become an effective approach to drug discovery, as it offers a new way to explore drugs. Based on the Science Citation Index Expanded (SCI-E) and Social Sciences Citation Index (SSCI) databases of the Web of Science core collection, this study presents a bibliometric analysis of drug repurposing publications from 2010 to 2020. Data
Guojun Sun +9 more
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In Vitro Screening for Drug Repositioning [PDF]
SLAS Discovery, 2015 Drug repositioning or repurposing has received much coverage in the scientific literature in recent years and has been responsible for the generation of both new intellectual property and investigational new drug submissions. The literature indicates a significant trend toward the use of computational- or informatics-based methods for generating ...
Graeme F, Wilkinson, Kevin, Pritchard
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A standard database for drug repositioning [PDF]
Scientific Data, 2017 AbstractDrug repositioning, the process of discovering, validating, and marketing previously approved drugs for new indications, is of growing interest to academia and industry due to reduced time and costs associated with repositioned drugs. Computational methods for repositioning are appealing because they putatively nominate the most promising ...
Brown, Adam S., Patel, Chirag J.
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Journal of Pharmaceutical Policy and Practice, 2020 Drug repositioning is the scientific strategy of investigating existing drugs for additional clinical indications. The advantages of drug repositioning are that it benefits patients and that it adds new indications to existing drugs for lower costs ...
A. B. Bayoumy +4 more
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A drug repositioning algorithm based on a deep autoencoder and adaptive fusion
BMC Bioinformatics, 2021 Background Drug repositioning has caught the attention of scholars at home and abroad due to its effective reduction of the development cost and time of new drugs.
Peng Chen +3 more
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Drug-Repositioning Approaches Based on Medical and Life Science Databases
Frontiers in Pharmacology, 2021 Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a therapeutic agent for a different disease. As information regarding the safety, pharmacokinetics, and formulation of existing drugs is already available, the cost ...
Yoshito Zamami +10 more
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An in silico drug repositioning workflow for host-based antivirals
STAR Protocols, 2021 Summary: Drug repositioning represents a cost- and time-efficient strategy for drug development. Artificial intelligence-based algorithms have been applied in drug repositioning by predicting drug-target interactions in an efficient and high throughput ...
Zexu Li +4 more
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Recent computational drug repositioning strategies against SARS-CoV-2
Computational and Structural Biotechnology Journal, 2022 Since COVID-19 emerged in 2019, significant levels of suffering and disruption have been caused on a global scale. Although vaccines have become widely used, the virus has shown its potential for evading immunities or acquiring other novel ...
Lu Lu +6 more
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Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning [PDF]
International Journal of Molecular Sciences, 2020 Chagas disease, caused by the parasite Trypanosoma cruzi, affects millions of people in South America. The current treatments are limited, have severe side effects, and are only partially effective. Drug repositioning, defined as finding new indications for already approved drugs, has the potential to provide new therapeutic options for Chagas. In this
Melissa F. Adasme +11 more
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BMC Bioinformatics, 2018 Background Drug repositioning is the process of identifying new uses for existing drugs. Computational drug repositioning methods can reduce the time, costs and risks of drug development by automating the analysis of the relationships in pharmacology ...
Pathima Nusrath Hameed +3 more
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