Results 31 to 40 of about 1,936,479 (187)
A drug repositioning algorithm based on a deep autoencoder and adaptive fusion
BMC Bioinformatics, 2021 Background Drug repositioning has caught the attention of scholars at home and abroad due to its effective reduction of the development cost and time of new drugs.
Peng Chen +3 more
doaj +1 more source
Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning [PDF]
, 2015 Neglected tropical diseases cause significant morbidity and mortality and are a source of poverty in endemic countries. Only a few drugs are available to treat diseases such as leishmaniasis, Chagas' disease, human African trypanosomiasis and malaria ...
Leela Pavan Tadoori +24 more
core +2 more sources
Drug repositioning: A bibliometric analysis
Frontiers in Pharmacology, 2022 Drug repurposing has become an effective approach to drug discovery, as it offers a new way to explore drugs. Based on the Science Citation Index Expanded (SCI-E) and Social Sciences Citation Index (SSCI) databases of the Web of Science core collection, this study presents a bibliometric analysis of drug repurposing publications from 2010 to 2020. Data
Guojun Sun +9 more
openaire +3 more sources
Network Pharmacology for Drug Repositioning in Anti-Alzheimer’s Drug Development
, 2023 Alzheimer’s disease (AD) has become a public health emergency due to its complexity and heterogeneity; therefore, therapeutic regimens must focus on cure rather than symptom management.
Mitra, S. +4 more
core +1 more source
Recent computational drug repositioning strategies against SARS-CoV-2
Computational and Structural Biotechnology Journal, 2022 Since COVID-19 emerged in 2019, significant levels of suffering and disruption have been caused on a global scale. Although vaccines have become widely used, the virus has shown its potential for evading immunities or acquiring other novel ...
Lu Lu +6 more
doaj +1 more source
Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning [PDF]
International Journal of Molecular Sciences, 2020 Chagas disease, caused by the parasite Trypanosoma cruzi, affects millions of people in South America. The current treatments are limited, have severe side effects, and are only partially effective. Drug repositioning, defined as finding new indications for already approved drugs, has the potential to provide new therapeutic options for Chagas. In this
Melissa F. Adasme +11 more
openaire +2 more sources
Topological network measures for drug repositioning. [PDF]
, 2020 peer reviewedDrug repositioning has received increased attention since the past decade as several blockbuster drugs have come out of repositioning. Computational approaches are significantly contributing to these efforts, of which, network-based methods ...
De Landtsheer, Sébastien +5 more
core +1 more source
RepCOOL: computational drug repositioning via integrating heterogeneous biological networks
Journal of Translational Medicine, 2020 Background It often takes more than 10 years and costs more than 1 billion dollars to develop a new drug for a particular disease and bring it to the market. Drug repositioning can significantly reduce costs and time in drug development.
Ghazale Fahimian +3 more
doaj +1 more source
BMC Bioinformatics, 2021 Background Drug repositioning refers to the identification of new indications for existing drugs. Drug-based inference methods for drug repositioning apply some unique features of drugs for new indication prediction. Complementary information is provided
Hailin Chen, Zuping Zhang, Jingpu Zhang
doaj +1 more source
Repositioning Natural Products in Drug Discovery [PDF]
Molecules, 2020 Drug repositioning (o repurposing) has become one of the most popular and successful strategies to reduce failures typically associated with drug discovery [...]
Rastelli, G. +3 more
openaire +4 more sources