Results 21 to 30 of about 1,936,479 (187)
Transcriptome-Guided Drug Repositioning [PDF]
, 2023 Drug repositioning can save considerable time and resources and significantly speed up the drug development process. The increasing availability of drug action and disease-associated transcriptome data makes it an attractive source for repositioning ...
Nikoghosyan, Maria +7 more
core +3 more sources
Frontiers in Oncology, 2022 BK002 consists of Achyranthes japonica Nakai (AJN) and Melandrium firmum Rohrbach (MFR) that have been used as herbal medicines in China and Korea. AJN and MFR have been reported to have anti-inflammatory, anti-oxidative, and anti-cancer activities ...
Moon Nyeo Park +17 more
doaj +1 more source
International Journal of Epilepsy, 2016 AbstractRapid advances in pharmacotherapy and bioinformatics has led to the discovery and growing popularity of drug repositioning which includes re-investigating or recycling of existing drugs for new indications. There are innumerable advantages as well as challenges of drug repositioning. Since de-novo drug discovery takes plenty of time, effort and
Man Mohan Mehndiratta +4 more
openaire +1 more source
Drug target gene-based analyses of drug repositionability in rare and intractable diseases
Scientific Reports, 2021 Drug development for rare and intractable diseases has been challenging for decades due to the low prevalence and insufficient information on these diseases. Drug repositioning is increasingly being used as a promising option in drug development.
Ryuichi Sakate, Tomonori Kimura
doaj +1 more source
In Vitro Screening for Drug Repositioning [PDF]
SLAS Discovery, 2015 Drug repositioning or repurposing has received much coverage in the scientific literature in recent years and has been responsible for the generation of both new intellectual property and investigational new drug submissions. The literature indicates a significant trend toward the use of computational- or informatics-based methods for generating ...
Graeme F, Wilkinson, Kevin, Pritchard
openaire +2 more sources
Drug repositioning for personalized medicine [PDF]
Genome Medicine, 2012 Human diseases can be caused by complex mechanisms involving aberrations in numerous proteins and pathways. With recent advances in genomics, elucidating the molecular basis of disease on a personalized level has become an attainable goal. In many cases, relevant molecular targets will be identified for which approved drugs already exist, and the ...
Li, Yvonne Y, Jones, Steven JM
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Supercomputer-aided Drug Repositioning at Scale: Virtual Screening for SARS-CoV-2 Protease Inhibitor [PDF]
, 2020 Coronavirus diseases (COVID-19) outbreak has been labelled a pandemic. For the prioritization of treatments to cope with COVID-19, it is important to conduct rapid high-throughput screening of chemical compounds to repurposing the approved drugs, such ...
Jung Woo, Park +5 more
core +2 more sources
Drug repositioning for orphan diseases [PDF]
Briefings in Bioinformatics, 2011 The need and opportunity to discover therapeutics for rare or orphan diseases are enormous. Due to limited prevalence and/or commercial potential, of the approximately 6000 orphan diseases (defined by the FDA Orphan Drug Act as
Divya Sardana +5 more
openaire +3 more sources
Drug-Repositioning Approaches Based on Medical and Life Science Databases
Frontiers in Pharmacology, 2021 Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a therapeutic agent for a different disease. As information regarding the safety, pharmacokinetics, and formulation of existing drugs is already available, the cost ...
Yoshito Zamami +10 more
doaj +1 more source
Journal of Pharmaceutical Policy and Practice, 2020 Drug repositioning is the scientific strategy of investigating existing drugs for additional clinical indications. The advantages of drug repositioning are that it benefits patients and that it adds new indications to existing drugs for lower costs ...
A. B. Bayoumy +4 more
doaj +1 more source