Results 21 to 30 of about 60,427 (345)
Drug target gene-based analyses of drug repositionability in rare and intractable diseases
Scientific Reports, 2021 Drug development for rare and intractable diseases has been challenging for decades due to the low prevalence and insufficient information on these diseases. Drug repositioning is increasingly being used as a promising option in drug development.
Ryuichi Sakate, Tomonori Kimura
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HeteroKGRep: Heterogeneous Knowledge Graph based Drug Repositioning. [PDF]
Knowl Based SystCeskoutsé RFT +5 more
europepmc +3 more sources
Journal of Cheminformatics, 2020 Drug repositioning is the process of identifying novel therapeutic potentials for existing drugs and discovering therapies for untreated diseases. Drug repositioning, therefore, plays an important role in optimizing the pre-clinical process of developing
Tamer N. Jarada +2 more
doaj +1 more source
A multilayer network approach for guiding drug repositioning in neglected diseases [PDF]
, 2016 Drug development for neglected diseases has been historically hampered due to lack of market incentives. The advent of public domain resources containing chemical information from high throughput screenings is changing the landscape of drug discovery for
Berenstein, Ariel José +3 more
core +6 more sources
Journal of Pharmaceutical Policy and Practice, 2020 Drug repositioning is the scientific strategy of investigating existing drugs for additional clinical indications. The advantages of drug repositioning are that it benefits patients and that it adds new indications to existing drugs for lower costs ...
A. B. Bayoumy +4 more
doaj +1 more source
A drug repositioning algorithm based on a deep autoencoder and adaptive fusion
BMC Bioinformatics, 2021 Background Drug repositioning has caught the attention of scholars at home and abroad due to its effective reduction of the development cost and time of new drugs.
Peng Chen +3 more
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Drug-Repositioning Approaches Based on Medical and Life Science Databases
Frontiers in Pharmacology, 2021 Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a therapeutic agent for a different disease. As information regarding the safety, pharmacokinetics, and formulation of existing drugs is already available, the cost ...
Yoshito Zamami +10 more
doaj +1 more source
Biology-Informed Matrix Factorization: An AI-Driven Framework for Enhanced Drug Repositioning. [PDF]
Biology (Basel)Wang Y, Wang Y, Hu Y, Wang J.
europepmc +2 more sources
Drug repositioning: A bibliometric analysis
Frontiers in Pharmacology, 2022 Drug repurposing has become an effective approach to drug discovery, as it offers a new way to explore drugs. Based on the Science Citation Index Expanded (SCI-E) and Social Sciences Citation Index (SSCI) databases of the Web of Science core collection, this study presents a bibliometric analysis of drug repurposing publications from 2010 to 2020. Data
Guojun Sun +9 more
openaire +3 more sources
Viruses, 2020 Traditionally, drug discovery utilises a de novo design approach, which requires high cost and many years of drug development before it reaches the market.
Zheng Yao Low +2 more
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