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International Journal of Epilepsy, 2016 AbstractRapid advances in pharmacotherapy and bioinformatics has led to the discovery and growing popularity of drug repositioning which includes re-investigating or recycling of existing drugs for new indications. There are innumerable advantages as well as challenges of drug repositioning. Since de-novo drug discovery takes plenty of time, effort and
Man Mohan Mehndiratta +4 more
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Drug target gene-based analyses of drug repositionability in rare and intractable diseases
Scientific Reports, 2021 Drug development for rare and intractable diseases has been challenging for decades due to the low prevalence and insufficient information on these diseases. Drug repositioning is increasingly being used as a promising option in drug development.
Ryuichi Sakate, Tomonori Kimura
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In Vitro Screening for Drug Repositioning [PDF]
SLAS Discovery, 2015 Drug repositioning or repurposing has received much coverage in the scientific literature in recent years and has been responsible for the generation of both new intellectual property and investigational new drug submissions. The literature indicates a significant trend toward the use of computational- or informatics-based methods for generating ...
Graeme F, Wilkinson, Kevin, Pritchard
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Supercomputer-aided Drug Repositioning at Scale: Virtual Screening for SARS-CoV-2 Protease Inhibitor [PDF]
, 2020 Coronavirus diseases (COVID-19) outbreak has been labelled a pandemic. For the prioritization of treatments to cope with COVID-19, it is important to conduct rapid high-throughput screening of chemical compounds to repurposing the approved drugs, such ...
Jung Woo, Park +5 more
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Journal of Cheminformatics, 2020 Drug repositioning is the process of identifying novel therapeutic potentials for existing drugs and discovering therapies for untreated diseases. Drug repositioning, therefore, plays an important role in optimizing the pre-clinical process of developing
Tamer N. Jarada +2 more
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Drug repositioning for personalized medicine [PDF]
Genome Medicine, 2012 Human diseases can be caused by complex mechanisms involving aberrations in numerous proteins and pathways. With recent advances in genomics, elucidating the molecular basis of disease on a personalized level has become an attainable goal. In many cases, relevant molecular targets will be identified for which approved drugs already exist, and the ...
Li, Yvonne Y, Jones, Steven JM
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Journal of Pharmaceutical Policy and Practice, 2020 Drug repositioning is the scientific strategy of investigating existing drugs for additional clinical indications. The advantages of drug repositioning are that it benefits patients and that it adds new indications to existing drugs for lower costs ...
A. B. Bayoumy +4 more
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A drug repositioning algorithm based on a deep autoencoder and adaptive fusion
BMC Bioinformatics, 2021 Background Drug repositioning has caught the attention of scholars at home and abroad due to its effective reduction of the development cost and time of new drugs.
Peng Chen +3 more
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Drug-Repositioning Approaches Based on Medical and Life Science Databases
Frontiers in Pharmacology, 2021 Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a therapeutic agent for a different disease. As information regarding the safety, pharmacokinetics, and formulation of existing drugs is already available, the cost ...
Yoshito Zamami +10 more
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Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning [PDF]
, 2015 Neglected tropical diseases cause significant morbidity and mortality and are a source of poverty in endemic countries. Only a few drugs are available to treat diseases such as leishmaniasis, Chagas' disease, human African trypanosomiasis and malaria ...
Leela Pavan Tadoori +14 more
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