Results 11 to 20 of about 25,894 (252)
Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents
Computational and Structural Biotechnology Journal, 2022 Repositioning or repurposing drugs account for a substantial part of entering approval pipeline drugs, which indicates that drug repositioning has huge market potential and value.
Sha Zhu +3 more
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Drug Repositioning in Friedreich Ataxia [PDF]
Frontiers in Neuroscience, 2022 Friedreich ataxia is a rare neurodegenerative disorder caused by insufficient levels of the essential mitochondrial protein frataxin. It is a severely debilitating disease that significantly impacts the quality of life of affected patients and reduces ...
Alessandra Rufini +6 more
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Network mirroring for drug repositioning [PDF]
BMC Medical Informatics and Decision Making, 2017 Background Although drug discoveries can provide meaningful insights and significant enhancements in pharmaceutical field, the longevity and cost that it takes can be extensive where the success rate is low.
Sunghong Park +2 more
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Drug Repositioning Using Temporal Trajectories of Accompanying Comorbidities in Diabetes Mellitus [PDF]
Endocrinology and Metabolism, 2022 Background Most studies of systematic drug repositioning have used drug-oriented data such as chemical structures, gene expression patterns, and adverse effect profiles.
Namgi Park +4 more
doaj +1 more source
Frontiers in Oncology, 2022 BK002 consists of Achyranthes japonica Nakai (AJN) and Melandrium firmum Rohrbach (MFR) that have been used as herbal medicines in China and Korea. AJN and MFR have been reported to have anti-inflammatory, anti-oxidative, and anti-cancer activities ...
Moon Nyeo Park +17 more
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International Journal of Epilepsy, 2016 AbstractRapid advances in pharmacotherapy and bioinformatics has led to the discovery and growing popularity of drug repositioning which includes re-investigating or recycling of existing drugs for new indications. There are innumerable advantages as well as challenges of drug repositioning. Since de-novo drug discovery takes plenty of time, effort and
Man Mohan Mehndiratta +4 more
openaire +1 more source
Drug target gene-based analyses of drug repositionability in rare and intractable diseases
Scientific Reports, 2021 Drug development for rare and intractable diseases has been challenging for decades due to the low prevalence and insufficient information on these diseases. Drug repositioning is increasingly being used as a promising option in drug development.
Ryuichi Sakate, Tomonori Kimura
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Drug repositioning for personalized medicine [PDF]
Genome Medicine, 2012 Human diseases can be caused by complex mechanisms involving aberrations in numerous proteins and pathways. With recent advances in genomics, elucidating the molecular basis of disease on a personalized level has become an attainable goal. In many cases, relevant molecular targets will be identified for which approved drugs already exist, and the ...
Li, Yvonne Y, Jones, Steven JM
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Transcriptome-Guided Drug Repositioning [PDF]
Pharmaceutics, 2019 Drug repositioning can save considerable time and resources and significantly speed up the drug development process. The increasing availability of drug action and disease-associated transcriptome data makes it an attractive source for repositioning studies.
Arsen Arakelyan +7 more
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Journal of Cheminformatics, 2020 Drug repositioning is the process of identifying novel therapeutic potentials for existing drugs and discovering therapies for untreated diseases. Drug repositioning, therefore, plays an important role in optimizing the pre-clinical process of developing
Tamer N. Jarada +2 more
doaj +1 more source