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Drug repositioning: a brief overview [PDF]
Journal of Pharmacy and Pharmacology, 2020 Abstract Objectives Drug repositioning, that is, the use of a drug in an indication other than the one for which it was initially marketed, is a growing trend. Its origins lie mainly in the attrition experienced in recent years in the field of new drug discovery.
Jourdan, Jean-Pierre +3 more
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Computational and Structural Biotechnology Journal, 2020 Drug repositioning aims to find new indications for existing drugs in order to reduce drug development cost and time. Currently,there are numerous stories of successful drug repositioning that have been reported and many repurposed drugs are already ...
Daniele Parisi +5 more
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Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents
Computational and Structural Biotechnology Journal, 2022 Repositioning or repurposing drugs account for a substantial part of entering approval pipeline drugs, which indicates that drug repositioning has huge market potential and value.
Sha Zhu +3 more
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Drug Repositioning in Friedreich Ataxia [PDF]
Frontiers in Neuroscience, 2022 Friedreich ataxia is a rare neurodegenerative disorder caused by insufficient levels of the essential mitochondrial protein frataxin. It is a severely debilitating disease that significantly impacts the quality of life of affected patients and reduces ...
Alessandra Rufini +6 more
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Network mirroring for drug repositioning [PDF]
BMC Medical Informatics and Decision Making, 2017 Background Although drug discoveries can provide meaningful insights and significant enhancements in pharmaceutical field, the longevity and cost that it takes can be extensive where the success rate is low.
Sunghong Park +2 more
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Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning [PDF]
International Journal of Molecular Sciences, 2020 Chagas disease, caused by the parasite Trypanosoma cruzi, affects millions of people in South America. The current treatments are limited, have severe side effects, and are only partially effective. Drug repositioning, defined as finding new indications for already approved drugs, has the potential to provide new therapeutic options for Chagas. In this
Melissa F. Adasme +11 more
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International Journal of Epilepsy, 2016 AbstractRapid advances in pharmacotherapy and bioinformatics has led to the discovery and growing popularity of drug repositioning which includes re-investigating or recycling of existing drugs for new indications. There are innumerable advantages as well as challenges of drug repositioning. Since de-novo drug discovery takes plenty of time, effort and
Man Mohan Mehndiratta +4 more
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Frontiers in Oncology, 2022 BK002 consists of Achyranthes japonica Nakai (AJN) and Melandrium firmum Rohrbach (MFR) that have been used as herbal medicines in China and Korea. AJN and MFR have been reported to have anti-inflammatory, anti-oxidative, and anti-cancer activities ...
Moon Nyeo Park +17 more
doaj +1 more source
A brief overview of current drug repurposing approaches for COVID-19 management [PDF]
, 2020 This brief overview is intended to shed light on the current drug repositioning (also called drug repurposing) in the therapeutics of the novel coronavirus disease which emerged in 2019 (COVID-19).
Rodrigues, Pedro da Fonseca Soares +1 more
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Transcriptome-Guided Drug Repositioning [PDF]
Pharmaceutics, 2019 Drug repositioning can save considerable time and resources and significantly speed up the drug development process. The increasing availability of drug action and disease-associated transcriptome data makes it an attractive source for repositioning studies.
Arsen Arakelyan +7 more
openaire +3 more sources