Results 11 to 20 of about 25,687 (255)
Computational and Structural Biotechnology Journal, 2020 Drug repositioning aims to find new indications for existing drugs in order to reduce drug development cost and time. Currently,there are numerous stories of successful drug repositioning that have been reported and many repurposed drugs are already ...
Daniele Parisi +5 more
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Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents
Computational and Structural Biotechnology Journal, 2022 Repositioning or repurposing drugs account for a substantial part of entering approval pipeline drugs, which indicates that drug repositioning has huge market potential and value.
Sha Zhu +3 more
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Viruses, 2020 Traditionally, drug discovery utilises a de novo design approach, which requires high cost and many years of drug development before it reaches the market.
Zheng Yao Low +2 more
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Computational Drug Repositioning: Current Progress and Challenges
Applied Sciences, 2020 Novel drug discovery is time-consuming, costly, and a high-investment process due to the high attrition rate. Therefore, many trials are conducted to reuse existing drugs to treat pressing conditions and diseases, since their safety profiles and ...
Younhee Ko
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Some Aspects and Convergence of Human and Veterinary Drug Repositioning [PDF]
MoleculesDrug innovation traditionally follows a de novo approach with new molecules through a complex preclinical and clinical pathway. In addition to this strategy, drug repositioning has also become an important complementary approach, which can be shorter ...
Patrik Mag +3 more
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Drug Repositioning in Friedreich Ataxia [PDF]
Frontiers in Neuroscience, 2022 Friedreich ataxia is a rare neurodegenerative disorder caused by insufficient levels of the essential mitochondrial protein frataxin. It is a severely debilitating disease that significantly impacts the quality of life of affected patients and reduces ...
Alessandra Rufini +6 more
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Large Language Model–Enhanced Drug Repositioning Knowledge Extraction via Long Chain-of-Thought: Development and Evaluation Study [PDF]
JMIR Medical InformaticsBackgroundDrug repositioning is a pivotal strategy in pharmaceutical research, offering accelerated and cost-effective therapeutic discovery. However, biomedical information relevant to drug repositioning is often complex, dispersed, and underutilized ...
Hongyu Kang +5 more
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Network mirroring for drug repositioning [PDF]
BMC Medical Informatics and Decision Making, 2017 Background Although drug discoveries can provide meaningful insights and significant enhancements in pharmaceutical field, the longevity and cost that it takes can be extensive where the success rate is low.
Sunghong Park +2 more
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A Study on Methodologies of Drug Repositioning Using Biomedical Big Data: A Focus on Diabetes Mellitus [PDF]
Endocrinology and Metabolism, 2022 Drug repositioning is a strategy for identifying new applications of an existing drug that has been previously proven to be safe. Based on several examples of drug repositioning, we aimed to determine the methodologies and relevant steps associated with ...
Suehyun Lee, Seongwoo Jeon, Hun-Sung Kim
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Current Issues in Molecular Biology, 2022 Pacliatxel is a taxol-based chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Ji Hwan Lee +3 more
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