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Antifungal Drug Repurposing [PDF]
Antibiotics, 2020 Control of fungal pathogens is increasingly problematic due to the limited number of effective drugs available for antifungal therapy. Conventional antifungal drugs could also trigger human cytotoxicity associated with the kidneys and liver, including ...
Jong H. Kim +7 more
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A Maximum Flow-Based Approach to Prioritize Drugs for Drug Repurposing of Chronic Diseases
Life, 2021 The discovery of new drugs is required in the time of global aging and increasing populations. Traditional drug development strategies are expensive, time-consuming, and have high risks.
Md. Mohaiminul Islam +2 more
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Computational drug repurposing based on electronic health records: a scoping review
npj Digital Medicine, 2022 Computational drug repurposing methods adapt Artificial intelligence (AI) algorithms for the discovery of new applications of approved or investigational drugs.
Nansu Zong +12 more
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Pharmacology Research & PerspectivesDrug repurposing is an authentic, emerging, and growing aspect of drug development when the demand for new therapeutic solutions is high. Many repurposed drugs have been discovered by serendipity or a non‐ordered process driven by chance and sharp ...
Richard Head +2 more
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Protein sequence analysis in the context of drug repurposing
BMC Medical Informatics and Decision MakingMotivation Drug repurposing speeds up the development of new treatments, being less costly, risky, and time consuming than de novo drug discovery. There are numerous biological elements that contribute to the development of diseases and, as a result, to ...
Natalia García Sánchez +3 more
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Literature data-based de novo candidates for drug repurposing
BMC BioinformaticsBackground Drug repurposing offers a promising strategy for drug discovery. Drug repurposing involves identifying new therapeutic indications for existing, marketed drugs, thereby reducing the risks, costs, and time typically required for drug ...
Xianglong Liang, Xin Jiang, Yifang Ma
doaj +1 more source
Artificial intelligence in COVID-19 drug repurposing
The Lancet: Digital Health, 2020 Summary: Drug repurposing or repositioning is a technique whereby existing drugs are used to treat emerging and challenging diseases, including COVID-19.
Yadi Zhou, PhD +4 more
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Trends in drug repurposing for chronic hepatitis-B infection: Bibliometric-based approach 1990-2024 [PDF]
BIO Web of ConferencesChronic hepatitis B (CHB) infection is still a world problem today, especially in the developing countries. Until now, treatment related to CHB is still being continuously pursued using a variety of the latest approaches.
Irham Lalu Muhammad +6 more
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Clinical and Translational MedicinePurpose Systematic repurposing of approved medicines for another indication may accelerate drug development in oncology. We present a strategy combining biomarker testing with drug repurposing to identify new treatments for patients with advanced cancer.
Imogen R. Walpole +8 more
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Drug repurposing for rare: progress and opportunities for the rare disease community
Frontiers in MedicineRepurposing is one of the key opportunities to address the unmet rare diseases therapeutic need. Based on cases of drug repurposing in small population conditions, and previous work in drug repurposing, we analyzed the most important lessons learned ...
Anneliene Hechtelt Jonker +19 more
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