Results 1 to 10 of about 45,859 (253)
Antifungal Drug Repurposing [PDF]
Antibiotics, 2020 Control of fungal pathogens is increasingly problematic due to the limited number of effective drugs available for antifungal therapy. Conventional antifungal drugs could also trigger human cytotoxicity associated with the kidneys and liver, including ...
Jong H. Kim +7 more
doaj +3 more sources
Drug Repurposing for Rare Diseases [PDF]
Trends in Pharmacological Sciences, 2021 Currently, there are about 7000 identified rare diseases, together affecting 10% of the population. However, fewer than 6% of all rare diseases have an approved treatment option, highlighting their tremendous unmet needs in drug development. The process of repurposing drugs for new indications, compared with the development of novel orphan drugs, is a ...
Mieke Van Haelst +2 more
exaly +3 more sources
molIEreVIS: exploring and interpreting the evidence behind drug repurposing predictions [PDF]
Frontiers in BioinformaticsIntroductionFinding new uses for existing drugs, known as drug repurposing, is a widely adopted drug development strategy in the pharmaceutical industry.
Amal Alnouri +7 more
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Drug databases and their contributions to drug repurposing
Genomics, 2020 Drug repurposing is an interesting field in the drug discovery scope because of reducing time and cost. It is also considered as an appropriate method for finding medications for orphan and rare diseases. Hence, many researchers have proposed novel methods based on databases which contain different information.
Yosef Masoudi-Sobhanzadeh +2 more
exaly +3 more sources
Drug-disease networks and drug repurposing. [PDF]
PLoS Comput BiolAbstract Repurposing existing drugs to treat new diseases is a cost-effective alternative to de novo drug development, but there are millions of potential drug-disease combinations to be considered with only a small fraction being viable.
Polanco A, Newman MEJ.
europepmc +4 more sources
Drug Repurposing as an Effective Drug Discovery Strategy: A Critical Review [PDF]
Drug Design, Development and TherapyAbdulaziz H Al Khzem,1 Saad M Wali2 1Department of Pharmaceutical Chemistry, College of Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Eastern Province, Kingdom of Saudi Arabia; 2Pharmacology and Toxicology Department, College of ...
Al Khzem AH, Wali SM
doaj +2 more sources
Does collective consciousness compromise during epidemics and pandemics? [PDF]
EAI Endorsed Transactions on Smart Cities, 2021 The ongoing pandemic, COVID-19, has received unprecedented global attention. Though a pathogen is essentially the causative agent, the dynamics of the cause-effect in major events like the ongoing COVID-19 pandemic is not ...
Anoushka Khanna +3 more
doaj +1 more source
Editorial: Drug Repurposing [PDF]
Frontiers in Medicine, 2019 Pan Pantziarka +5 more
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ADVANCES AND DEVELOPMENTS IN DRUG REPURPOSING; STATE OF ART [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2023 Although the rapid progress in science and technology, developing new drugs from scratch has been expensive in recent decades. As a result, drug-repurposing, which implies seeking new utilizes for presently approved drugs instead of discovering new drug ...
Sarmad noori +2 more
doaj +1 more source
Paclitaxel and Therapeutic Drug Monitoring with Microsampling in Clinical Practice
Pharmaceuticals, 2023 Paclitaxel is an anticancer agent efficacious in various tumors. There is large interindividual variability in drug plasma concentrations resulting in a wide variability in observed toxicity in patients.
Mirjana Radovanovic +4 more
doaj +1 more source