Results 21 to 30 of about 45,859 (253)

Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining [PDF]

Royal Society Open Science, 2018
Drug repurposing aims to find novel indications of clinically used or experimental drugs. Because drug data already exist, drug repurposing may save time and cost, and bypass safety concerns.
Tsang-Pai Liu, Yao-Yu Hsieh, Chia-Jung Chou, Pei-Ming Yang   +3 more
doaj   +1 more source

Drug Repurposing in Human Cancers

Current Medicinal Chemistry, 2020
Drug Repurposing in Human ...
Grassi G., Grassi M.
openaire   +3 more sources

Buying time: Drug repurposing to treat the host in COVID‐19H

Pharmacology Research & Perspectives, 2020
In 2016 Fedson stated …. “For almost two decades, leading scientists and health officials have warned that we must prepare for a potentially devastating global pandemic of an infectious disease. Initial concern was focused on …H5N1….
Jennifer H. Martin, Julian Clark, Richard Head   +2 more
doaj   +1 more source

Network Crosstalk as a Basis for Drug Repurposing

Frontiers in Genetics, 2022
The need for systematic drug repurposing has seen a steady increase over the past decade and may be particularly valuable to quickly remedy unexpected pandemics. The abundance of functional interaction data has allowed mapping of substantial parts of the
Dimitri Guala, Dimitri Guala, Erik L. L. Sonnhammer   +2 more
doaj   +1 more source

A phase 1 clinical trial of the repurposable acetyllysine mimetic, n-methyl-2-pyrrolidone (NMP), in relapsed or refractory multiple myeloma

Clinical Epigenetics, 2023
Background N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP demonstrates immunomodulatory and
Jake Shortt, Peter Galettis, Chan Y. Cheah, Joanne Davis, Mandy Ludford-Menting, Emma K. Link, Jennifer H. Martin, Rachel Koldej, David Ritchie   +8 more
doaj   +1 more source

Drug repurposing in cancer

Pharmacological Research, 2017
Cancer is a major health issue worldwide, and the global burden of cancer is expected to increase in the coming years. Whereas the limited success with current therapies has driven huge investments into drug development, the average number of FDA approvals per year has declined since the 1990s.
Linda, Sleire, Hilde Elise, Førde, Inger Anne, Netland, Lina, Leiss, Bente Sandvei, Skeie, Per Øyvind, Enger   +5 more
openaire   +2 more sources

Drug Repurposing: Then, Now, and in the Future

Drug Repurposing, 2022
Contrary to the definition of a drug, drug repurposing usually involves the redevelopment of an active pharmaceutical ingredient (API) for a substantially different medical use; only rarely is this done with an off-the-shelf drug approved for a different disease.
openaire   +1 more source

Drug Repurposing

Citation: 'drug repurposing' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12648 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Ravichandran Veerasamy, Raghuraman Seenivasan, Prabha Thangavelu, Harish Rajak   +3 more
  +7 more sources

COVID infection in 4 steps: Thermodynamic considerations reveal how viral mucosal diffusion, target receptor affinity and furin cleavage act in concert to drive the nature and degree of infection in human COVID-19 disease

Heliyon, 2023
We have developed a mechanistic model of SARS-CoV-2 and SARS-CoV infection, exploring the relationship between the viral diffusion in the mucosa and viral affinity for the angiotensin converting enzyme 2 (ACE2) target. Utilising the structural similarity
Marko Popovic, Jennifer H. Martin, Richard J. Head   +2 more
doaj   +1 more source

Repurposing – second life for drugs [PDF]

Pharmacia, 2022
Drug repurposing refers to finding new indications for existing drugs. The paradigm shift from traditional drug discovery to drug repurposing is driven by the fact that new drug pipelines are getting dried up because of mounting Research &amp ...
Porkodi Ayyar, Umamaheswari Subramanian
doaj   +3 more sources