Results 21 to 30 of about 45,299 (154)
Drug Repurposing in Human Cancers
Current Medicinal Chemistry, 2020 Drug Repurposing in Human ...
Grassi G., Grassi M.
openaire +3 more sources
Clinical Epigenetics, 2023 Background N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP demonstrates immunomodulatory and
Jake Shortt +8 more
doaj +1 more source
Pharmacological Research, 2017 Cancer is a major health issue worldwide, and the global burden of cancer is expected to increase in the coming years. Whereas the limited success with current therapies has driven huge investments into drug development, the average number of FDA approvals per year has declined since the 1990s.
Linda, Sleire +5 more
openaire +2 more sources
Drug Repurposing: Then, Now, and in the Future
Drug Repurposing, 2022 Contrary to the definition of a drug, drug repurposing usually involves the redevelopment of an active pharmaceutical ingredient (API) for a substantially different medical use; only rarely is this done with an off-the-shelf drug approved for a different disease.
openaire +1 more source
Citation: 'drug repurposing' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12648 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Ravichandran Veerasamy +3 more
+7 more sources
Heliyon, 2023 We have developed a mechanistic model of SARS-CoV-2 and SARS-CoV infection, exploring the relationship between the viral diffusion in the mucosa and viral affinity for the angiotensin converting enzyme 2 (ACE2) target. Utilising the structural similarity
Marko Popovic +2 more
doaj +1 more source
Repurposing – second life for drugs [PDF]
Pharmacia, 2022 Drug repurposing refers to finding new indications for existing drugs. The paradigm shift from traditional drug discovery to drug repurposing is driven by the fact that new drug pipelines are getting dried up because of mounting Research & ...
Porkodi Ayyar, Umamaheswari Subramanian
doaj +3 more sources
Drug reprofiling history and potential therapies against Parkinson’s disease
Frontiers in Pharmacology, 2022 Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing “old” drugs to treat typical and uncommon illnesses is progressively becoming an appealing proposition. Drug repurposing is the
Komal Latif +10 more
doaj +1 more source
A machine learning and network framework to discover new indications for small molecules.
PLoS Computational Biology, 2020 Drug repurposing, identifying novel indications for drugs, bypasses common drug development pitfalls to ultimately deliver therapies to patients faster. However, most repurposing discoveries have been led by anecdotal observations (e.g.
Coryandar Gilvary +5 more
doaj +1 more source
Drug Repurposing for Rare Orphan Diseases Using Machine Learning Techniques
Proceedings of the International Florida Artificial Intelligence Research Society Conference, 2022 New drug discovery is a time-consuming and costly process. Several drugs have been in clinical trials for a very long period. Finding a new target for existing medications can be an effective strategy to reduce the lengthy and costly drug development ...
Rajesh Manicavasaga +3 more
doaj +1 more source