Results 41 to 50 of about 1,830,783 (287)
Activity profile of an FDA-approved compound library against Schistosoma mansoni [PDF]
, 2015 As plans to expand mass drug treatment campaigns to fight schistosomiasis form, worries about reliance on praziquantel as the sole available treatment motivate the investigation for novel antischistosomal compounds.
Gordana Panic +11 more
core +2 more sources
Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers
, 2021 Drug repurposing is promoted as a cost- and time-effective mechanism for providing new medicines. Often, however, there is insufficient consideration by academic researchers of the processes required to ensure that a repurposed drug can be used for a new
Baell, Jonathan +14 more
core +1 more source
Clinical Epigenetics, 2023 Background N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP demonstrates immunomodulatory and
Jake Shortt +8 more
doaj +1 more source
Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni [PDF]
, 2015 BACKGROUND: Drug discovery for the neglected tropical disease schistosomiasis has a high priority. Anticancer drugs, especially protein kinase inhibitors, might serve as a starting point for drug discovery owing to the importance of protein kinases in ...
Cowan, Noemi +3 more
core +1 more source
A Drug Repurposing Pipeline Based on Bladder Cancer Integrated Proteotranscriptomics Signatures
, 2023 Delivering better care for patients with bladder cancer (BC) necessitates the development of novel therapeutic strategies that address both the high disease heterogeneity and the limitations of the current therapeutic modalities, such as drug low ...
Frantzi, Maria +6 more
core +1 more source
Drug Repurposing for Therapeutic Discovery against Human Metapneumovirus Infection
, 2022 Human metapneumovirus (HMPV) is recognized as an important cause of pneumonia in infants, in the elderly, and in immunocompromised individuals worldwide.
Guillon, Patrice +4 more
core +1 more source
Drug Repurposing: Then, Now, and in the Future
Drug Repurposing, 2022 Contrary to the definition of a drug, drug repurposing usually involves the redevelopment of an active pharmaceutical ingredient (API) for a substantially different medical use; only rarely is this done with an off-the-shelf drug approved for a different disease.
openaire +1 more source
Gene based message passing for drug repurposing
, 2023 Summary: The medicinal effect of a drug acts through a series of genes, and the pathological mechanism of a disease is also related to genes with certain biological functions. However, the complex information between drug or disease and a series of genes
Zhiming Dai +9 more
core +1 more source
Heliyon, 2023 We have developed a mechanistic model of SARS-CoV-2 and SARS-CoV infection, exploring the relationship between the viral diffusion in the mucosa and viral affinity for the angiotensin converting enzyme 2 (ACE2) target. Utilising the structural similarity
Marko Popovic +2 more
doaj +1 more source
, 2023 Code used for data analysis of drug repurposing approach to target inflammation in ...
kravneet
core +1 more source