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Pharmaceutics, 2021 Drug repurposing is a valuable alternative to traditional drug design based on the assumption that medicines have multiple functions. Computer-based techniques use ever-growing drug databases to uncover new drug repurposing hints, which require further ...
Vlad Groza +3 more
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Pharmacological Research, 2017 Cancer is a major health issue worldwide, and the global burden of cancer is expected to increase in the coming years. Whereas the limited success with current therapies has driven huge investments into drug development, the average number of FDA approvals per year has declined since the 1990s.
Linda, Sleire +5 more
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Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining [PDF]
Royal Society Open Science, 2018 Drug repurposing aims to find novel indications of clinically used or experimental drugs. Because drug data already exist, drug repurposing may save time and cost, and bypass safety concerns.
Tsang-Pai Liu +3 more
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Buying time: Drug repurposing to treat the host in COVID‐19H
Pharmacology Research & Perspectives, 2020 In 2016 Fedson stated …. “For almost two decades, leading scientists and health officials have warned that we must prepare for a potentially devastating global pandemic of an infectious disease. Initial concern was focused on …H5N1….
Jennifer H. Martin +2 more
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Network Crosstalk as a Basis for Drug Repurposing
Frontiers in Genetics, 2022 The need for systematic drug repurposing has seen a steady increase over the past decade and may be particularly valuable to quickly remedy unexpected pandemics. The abundance of functional interaction data has allowed mapping of substantial parts of the
Dimitri Guala +2 more
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Clinical Epigenetics, 2023 Background N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP demonstrates immunomodulatory and
Jake Shortt +8 more
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A Drug Repurposing Pipeline Based on Bladder Cancer Integrated Proteotranscriptomics Signatures
, 2023 Delivering better care for patients with bladder cancer (BC) necessitates the development of novel therapeutic strategies that address both the high disease heterogeneity and the limitations of the current therapeutic modalities, such as drug low ...
Frantzi, Maria +6 more
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Drug Repurposing for Therapeutic Discovery against Human Metapneumovirus Infection
, 2022 Human metapneumovirus (HMPV) is recognized as an important cause of pneumonia in infants, in the elderly, and in immunocompromised individuals worldwide.
Guillon, Patrice +4 more
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Heliyon, 2023 We have developed a mechanistic model of SARS-CoV-2 and SARS-CoV infection, exploring the relationship between the viral diffusion in the mucosa and viral affinity for the angiotensin converting enzyme 2 (ACE2) target. Utilising the structural similarity
Marko Popovic +2 more
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Drug Repurposing: Then, Now, and in the Future
Drug Repurposing, 2022 Contrary to the definition of a drug, drug repurposing usually involves the redevelopment of an active pharmaceutical ingredient (API) for a substantially different medical use; only rarely is this done with an off-the-shelf drug approved for a different disease.
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