Results 61 to 70 of about 1,946,248 (285)

Phenotype versus genotype to optimize cancer dosing in the clinical setting—focus on 5‐fluorouracil and tyrosine kinase inhibitors

Pharmacology Research & Perspectives
Cancer medicines often have narrow therapeutic windows; toxicity can be severe and sometimes fatal, but inadequate dose intensity reduces efficacy and survival.
Jennifer H. Martin, Peter Galettis, Alex Flynn, Jennifer Schneider   +3 more
doaj   +1 more source

A novel drug repurposing approach for non-small cell lung cancer using deep learning.

PLoS ONE, 2020
Drug repurposing is an attractive and pragmatic way offering reduced risks and development time in the complicated process of drug discovery. In the past, drug repurposing has been largely accidental and serendipitous. The most successful examples so far
Bingrui Li, Chan Dai, Lijun Wang, Hailong Deng, Yingying Li, Zheng Guan, Haihong Ni   +6 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

COVID19 Approved Drug Repurposing: Pocket Similarity Approach [PDF]

, 2020
SARS CoV 2 has spread worldwide and caused a major outbreak of coronavirus disease 2019 (COVID-19). To date, no licensed drug or a vaccine is available against COVID19.Starting from all of the resolved SARS CoV2 crystal structures, this study aims to ...
Mohamed, Fadlalla
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Knowledge-driven drug repurposing using a comprehensive drug knowledge graph

Health Informatics Journal, 2020
Due to the huge costs associated with new drug discovery and development, drug repurposing has become an important complement to the traditional de novo approach.
Yongjun Zhu, Chao Che, Bo Jin, Ningrui Zhang, Chang Su, Fei Wang   +5 more
doaj   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

A novel approach for drug discovery-drug repurposing

National Journal of Physiology, Pharmacy and Pharmacology, 2022
Drug repurposing refers to finding a new indication for a pre-existing drug. It is a novel way of drug discovery that greatly reduces the time and money spent in the drug discovery process.
Muthu Meera, Sindhu Sekar, Rajkishore Mahatao   +2 more
doaj   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability [PDF]

Advanced science
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Kong Y, Zhou W, Sun Y, Huang Z, Liu Z, Kumar. S U, Li C, Lu Y, Song C, Ciliberto V, Mack M, Kim L, Hu Z, Luo F, Cao A, Sun Z.   +15 more
europepmc   +2 more sources

bio-ontology-research-group/multi-drug-embedding: Method for drug repurposing from knowledge graphs and literature

, 2018
Method for drug repurposing from knowledge graphs and ...
AlShahrani, Mona, Hoehndorf, Robert
core   +1 more source